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The blood ApoM-S1P complex regulates vascular functions, but its role in neurogenic niches remains unclear. Here, the authors show that the blood ApoM-S1P complex preserves V-SVZ homeostasis and protects against early features of Alzheimer’s disease.

It is a challenge to optimize vertical NAND (V-NAND) flash memory for physical unclonable function (PUF) applications. Here, the authors present a method for generating PUF data using gate-induced-drain-leakage erase, improving reliability of V-NAND flash memory-based PUFs and adding concealable characteristics.

Long-term stability is a key challenge for ruthenium-based oxygen evolution reaction (OER) catalysts. Here, the authors present a RuO2/LiCoO2 catalyst with dynamic Li dissolution, which weakens the covalency of the Ru-O bond to prevent the lattice oxygen mechanism, thereby ensuring stable acidic OER.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Expanding the genetic code with unnatural amino acids in model organisms is a powerful tool for investigatingin vivocellular proteins and processes. Here the authors re-engineer the amber stop codon in laboratory mice to allow site-specific incorporation of unnatural amino acids in target proteins.

This study shows that long-term exercise improves brain waste clearance by enhancing glymphatic influx and mLV flow through neuroinflammation reduction, highlighting exercise as a promising non-drug strategy to prevent neurodegenerative diseases.

Tissue engineering is essential for drug screening and regenerative medicine. Here, authors developed an acoustofluidic method that can induce morphogenesis of therapeutic tissues at varied dimensions/scales.

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Norihiro Kato and colleagues perform a meta-analysis of genome-wide association studies to identify common variants associated with blood pressure variation in east Asians. They identify five new genome-wide significant signals and replicate seven loci previously discovered in populations of European ancestry.

Sung et. al. identify genetic, molecular and clinical risk factors for immune-related adverse events in multicancer cohorts of patients treated with checkpoint inhibitors and develop predictive models that they validate in an independent cohort.

Structural variations (SV) contribute to inter-individual variability. Here, the authors describe a first-generation multi-ancestry Asian SV catalogue containing 73,035 SVs from 8392 Singaporeans to provide insights into Asian SV diversity.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Uninterrupted monitoring of pressure and temperature at skin interfaces can help to minimize the potential for pressure injuries in hospitalized or bedridden patients. Here, the authors introduce a soft, skin-mountable sensor that can continuously provide readings via antennas mounted under bedding, and demonstrate the functionality and robustness of the devices on patients.

Magnetic random access memory current uses spin transfer torque for switching, which limits the speed of switching operation, and the number of times the device can be switched before failure. Here, Yang et al. demonstrate field free switching using spin-orbit torque offering a pathway to overcome these limitations.

Toxic protein aggregation is a hallmark of various neurodegenerative diseases. Here, authors show that ATP-independent membrane protein chaperones can serve as a simple design platform for targeting proteotoxic aggregates linked to Huntington’s disease.

A millimetre-scale bioresorbable optoelectronic system with an onboard power supply and a wireless, optical control mechanism is developed for general applications in electrotherapy and specific uses in temporary cardiac pacing.

Sea water can be separated into desalted and concentrated streams without using a membrane by creating an ion-depleted region near a nanojunction.

Ni-rich cathodes in all-solid-state batteries experience capacity fading due to surface degradation, particle isolation and detachment at the cathode–electrolyte interface. This study quantifies these degradation factors, showing that detachment increases with Ni content and emphasizing the need for strategies to address these challenges.

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Pulmonary function is influenced by environmental factors, lifestyle, and genetics. Here, in a multiethnic GWAS meta-analysis for pulmonary function traits, the authors identify over 50 additional genetic loci, a subset of which are specific for European, African, Asian, or Hispanic/Latino ancestry.

The origin of Cnidaria—coral and jellyfish—is still unsolved in the basal metazoan phylogeny. Here, a Cambrian fossil of a stem-group cnidarian,Cambroctoconus orientalisgen. et sp. nov., is found to bear octoradial symmetry, but no jelly-like mesenchyme, suggesting this evolved after octoradial symmetry.

The interface between two insulating oxides can play host to magnetic ordering. Here, the authors manipulate the spin transport in a hybrid magnetic tunnel junction comprising two ferromagnets: one a cobalt layer and the other the interface between lanthanum aluminate and strontium titanate.

Biofuel cells can be used as power sources for implantable biomedical devices, but suffer from limited power and lifetime. Here, Kwon et al.fabricate biscrolled carbon nanotube yarn electrodes, and demonstrate high fuel cell performances when used for glucose energy harvesting.

Semiconductors are promising for high performance spintronics but the low functioning temperature hampers their applications. Here the authors achieve a strong room temperature modulation of spin-dependent resistance in GaN nanowires, which marks an important step towards practical spintronic devices.

Controlled switching between states in materials with strong electronic correlations can form the basis for functional devices. Here, the authors use a scanning tunnelling microscope tip to switch between a Mott insulator state and a metallic state with charge-density-wave domains in 1T-TaS₂.

The synthesis of sequence-regulated oligosulfates has not yet been established due to the difficulties in precise reactivity control. Here, the authors report a multi-directional divergent iterative method to furnish oligosulfates based on a chain homologation approach, in which the fluorosulfate unit is regenerated.

Interstitial macrophages (IM) are a specialised population of macrophage cells in the lungs which regulate lung inflammation. Here using mouse models, the authors show that a CD39⁺CD9⁺ IM population reduce IL-23/Th17 driven neutrophilic inflammation through suppression of NETosis.

Park et al. shed light on the dynamics of DNA demethylation during adipocyte differentiation, which is shown to be regulated by the transcription factor C/EBPδ and the DNA methylation eraser TET3.

HEPN–MNT is a bacterial type VII toxin-antitoxin (TA) system, comprising the HEPN toxin and the MNT antitoxin. Crystal structures and functional assays of the HEPN–MNT module suggest that HEPN is a metal-dependent RNase and identify its active site residues and regulatory mechanism.

Artificial molecules supported on templated surfaces attract enormous interest due to their tunable electronic properties. Here the authors use STM experiments and DFT calculations to show the formation of Pb artificial clusters on a IrTe₂ honeycomb template that are maximally stabilized by relativistic effects.

Upon cold exposure, two types of thermogenic fat cells, brown and beige adipocytes, are sequentially activated. Here, the authors show that E3 ubiquitin ligase RNF20 coordinates the sequential thermogenic activation through fat depot specific substrates.