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Advanced filters: Author: Sungmoo Lee Clear advanced filters

Pharmacodynamics of Akt drugs revealed by a kinase-modulated bioluminescent indicator

Measuring pharmacodynamics (PD) is vital for drug development but traditional PD studies are labor and resource intensive. Wu et al. introduce a kinase-modulated bioluminescent indicator for noninvasive visualization of Akt-related drug PD in living animals.

Yan Wu
Chenzhou Hao
Michael Z. Lin
Research11 Feb 2025
Nature Chemical Biology

P: 1-11
Synaptic basis of feature selectivity in hippocampal neurons

A temporally asymmetric synaptic plasticity kernel results from bidirectional modifications of synaptic weights around the induction of a place field.

Kevin C. Gonzalez
Adrian Negrean
Attila Losonczy
Research18 Dec 2024
Nature

Volume: 637, P: 1152-1160
A positively tuned voltage indicator for extended electrical recordings in the brain

The ASAP4 family of genetically encoded voltage indicators allows recording of action potentials and subthreshold activity with either one- or two-photon microscopy over extended periods of time.

S. Wenceslao Evans
Dong-Qing Shi
Michael Z. Lin
Research06 Jul 2023
Nature Methods

Volume: 20, P: 1104-1113
Improving a genetically encoded voltage indicator by modifying the cytoplasmic charge composition

Sungmoo Lee
Tristan Geiller
Bradley J. Baker
ResearchOpen Access15 Aug 2017
Scientific Reports

Volume: 7, P: 1-16
A dimeric fluorescent protein yields a bright, red-shifted GEVI capable of population signals in brain slice

Bumjun Yi
Bok Eum Kang
Bradley J. Baker
ResearchOpen Access12 Oct 2018
Scientific Reports

Volume: 8, P: 1-14