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Showing 1–4 of 4 results
Advanced filters: Author: Susma Gurung Clear advanced filters

  • Obesity is a global health challenge with an ongoing need for new medical treatments. Here, the authors show that artesunate, an FDA-approved treatment for severe malaria, can be repurposed for the treatment of obesity via GDF15/GFRAL signaling axis without overt side effects in mice and non-human primates.

    • Xuanming Guo
    • Pallavi Asthana
    • Hoi Leong Xavier Wong
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • The role of soluble angiotensin converting enzyme 2 (sACE2) in SARS-CoV-2 infection is not well understood. Here, authors show that membrane type 1 matrix metalloproteinase (MT1-MMP) releases sACE2 to promote SARS-CoV-2 cell entry in vitro and in vivo, and the upregulation of MT1-MMP may contribute to increased susceptibility to SARS-CoV-2 infection in ageing.

    • Xuanming Guo
    • Jianli Cao
    • Hoi Leong Xavier Wong
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Insulin sensitivity declines with age via unclear mechanisms. Here, the authors show that the activity of membrane type 1 matrix metalloproteinase (MT1-MMP) is increased with ageing, leading to cleavage of the insulin receptor, and show that metabolic effects can be rescued by MT1-MMP inhibition in mice.

    • Xuanming Guo
    • Pallavi Asthana
    • Hoi Leong Xavier Wong
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • The GDF15–GFRAL axis is key for regulating energy homeostasis and body weight. Membrane-bound matrix metalloproteinase 14 is shown to negatively regulate GFRAL, whereas its downregulation protects against diet-induced obesity through increased GDF15 signaling.

    • Chi Fung Willis Chow
    • Xuanming Guo
    • Hoi Leong Xavier Wong
    Research
    Nature Metabolism
    Volume: 4, P: 203-212