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Showing 1–4 of 4 results
Advanced filters: Author: Swarnendu Tripathi Clear advanced filters

  • Many fusion oncoproteins (FOs) form condensates, some form in the nucleus and regulate gene expression while others form in the cytoplasm and promote cell signaling. In this work, the authors report the analysis of physicochemical features to enable prediction of FO condensation behavior.

    • Swarnendu Tripathi
    • Hazheen K. Shirnekhi
    • Richard W. Kriwacki
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-25

  • Membraneless cellular assemblies termed biomolecular condensates — into which diverse biopolymers partition — mediate myriad biological processes. A study now reveals that physicochemical features, not specific stereochemistry, influence whether small molecules are enriched within or excluded from a diverse panel of condensates.

    • Bappaditya Chandra
    • Swarnendu Tripathi
    • Richard Kriwacki
    News & Views
    Nature Chemistry
    Volume: 16, P: 1743-1745

  • SPTBN1 mutations cause a neurodevelopmental syndrome characterized by intellectual disability, language and motor delays, autism, seizures and other features. The variants disrupt βII-spectrin function and disturb cytoskeletal organization and dynamics.

    • Margot A. Cousin
    • Blake A. Creighton
    • Damaris N. Lorenzo
    Research
    Nature Genetics
    Volume: 53, P: 1006-1021