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Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain

Intracerebral hemorrhage triggers astrocyte proliferation and mediates neural stem cell potential via Galectin3 signaling.

Swetlana Sirko
Christian Schichor
Magdalena Götz
ResearchOpen Access08 Dec 2023
Nature Medicine

Volume: 29, P: 3149-3161
Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter

White matter (WM) astrocytes differ significantly from gray matter astrocytes, with WM astrocytes in the forebrain exhibiting unique proliferation capacity, which is absent in cerebellar WM, suggesting region-specific astrocyte generation.

Riccardo Bocchi
Manja Thorwirth
Judith Fischer-Sternjak
ResearchOpen Access24 Feb 2025
Nature Neuroscience

Volume: 28, P: 457-469
Shared inflammatory glial cell signature after stab wound injury, revealed by spatial, temporal, and cell-type-specific profiling of the murine cerebral cortex

Glial cells and their crosstalk after injury are crucial for brain regeneration. Here, the authors show the spatial, temporal, and single-cell responses of glial cells after injury and identify shared pathways controlling glial reactivity.

Christina Koupourtidou
Veronika Schwarz
Jovica Ninkovic
ResearchOpen Access03 Apr 2024
Nature Communications

Volume: 15, P: 1-22
TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury

Zambusi, Novoselc et al. show that granulin-mediated clearance of cytoplasmic TDP-43⁺ condensates and lipid droplets in injury-activated microglia is required for their return to the homeostatic state and successful brain regeneration.

Alessandro Zambusi
Klara Tereza Novoselc
Jovica Ninkovic
Research24 Nov 2022
Nature Neuroscience

Volume: 25, P: 1608-1625
Reactive astrocyte nomenclature, definitions, and future directions

Good–bad binary classifications fail to describe reactive astrocytes in CNS disorders. Here, 81 researchers reach consensus on widespread misconceptions and provide definitions and recommendations for future research on reactive astrocytes.

Carole Escartin
Elena Galea
Alexei Verkhratsky
Reviews15 Feb 2021
Nature Neuroscience

Volume: 24, P: 312-325

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Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain

Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter

Shared inflammatory glial cell signature after stab wound injury, revealed by spatial, temporal, and cell-type-specific profiling of the murine cerebral cortex

TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury

Reactive astrocyte nomenclature, definitions, and future directions

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