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Showing 1–4 of 4 results
Advanced filters: Author: Sy Redding Clear advanced filters

  • This study defines how a short DNA sequence, known as the PAM, is critical for target DNA interrogation by the CRISPR-associated enzyme Cas9 — DNA melting and heteroduplex formation initiate near the PAM and extend directionally through the remaining target sequence, and the PAM is also required to activate the catalytic activity of Cas9.

    • Samuel H. Sternberg
    • Sy Redding
    • Jennifer A. Doudna
    Research
    Nature
    Volume: 507, P: 62-67

  • The transcription machinery must locate specific promoter sequences among a vast excess of nonspecific DNA. Real-time single-molecule experiments with E. coli RNA polymerase, combined with theoretical calculations, suggest that facilitated diffusion does not contribute to promoter targeting at physiologically relevant protein concentrations but that instead the promoter search is dominated by three-dimensional diffusion.

    • Feng Wang
    • Sy Redding
    • Eric C Greene
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 174-181