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Scientific Reports (72)
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Showing 51–100 of 171 results

Advanced filters: Author: Takashi Yoshimura Clear advanced filters

Seasonal regulation of the lncRNA LDAIR modulates self-protective behaviours during the breeding season

Transcriptomic and behavioural analyses of medaka fish demonstrate how photoperiodic activation of the long noncoding RNA LDAIR regulates behaviour in response to seasonal change.

Tomoya Nakayama
Tsuyoshi Shimmura
Takashi Yoshimura
Research08 Apr 2019
Nature Ecology & Evolution

Volume: 3, P: 845-852
Tenascin-C Modulates Adhesion of Cardiomyocytes to Extracellular Matrix during Tissue Remodeling after Myocardial Infarction

Kyoko Imanaka-Yoshida
Michiaki Hiroe
Toshimichi Yoshida
Research01 Jul 2001
Laboratory Investigation

Volume: 81, P: 1015-1024
Effective use of high CO₂ efflux at the soil surface in a tropical understory plant

Atsushi Ishida
Takashi Nakano
Jin Yoshimura
ResearchOpen Access11 Mar 2015
Scientific Reports

Volume: 5, P: 1-4
Dynamic plasticity in phototransduction regulates seasonal changes in color perception

Animal coloration and behavior can change seasonally, but it is unclear if visual sensitivity to color shifts as well. Here, Shimmura et al. show that medaka undergo seasonal behavioral change accompanied by altered expression of opsin genes, resulting in reduced visual sensitivity to mates during winter-like conditions.

Tsuyoshi Shimmura
Tomoya Nakayama
Takashi Yoshimura
ResearchOpen Access04 Sept 2017
Nature Communications

Volume: 8, P: 1-7
The saccus vasculosus of fish is a sensor of seasonal changes in day length

The saccus vasculosus is a circumventricular organ of the hypothalamus of many jawed fish whose function has remained a mystery for more than 300 years. Here the authors provide evidence that the saccus vasculosus functions as a sensor of seasonal changes in day length.

Yusuke Nakane
Keisuke Ikegami
Takashi Yoshimura
ResearchOpen Access02 Jul 2013
Nature Communications

Volume: 4, P: 1-7
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

A study of SARS-CoV-2 variants examining their transmission, infectivity, and potential resistance to therapies provides insights into the biology of the Delta variant and its role in the global pandemic.

Petra Mlcochova
Steven A. Kemp
Ravindra K. Gupta
ResearchOpen Access06 Sept 2021
Nature

Volume: 599, P: 114-119
Risk analyses of nocturia on incident poor sleep and vice versa: the Nagahama study

Hiromitsu Negoro
Kazuya Setoh
Takashi Kobayashi
ResearchOpen Access11 Jun 2023
Scientific Reports

Volume: 13, P: 1-7
Enhanced mitochondrial oxidative metabolism in peripheral blood mononuclear cells is associated with fatty liver in obese young adults

Ryosuke Shirakawa
Takayuki Nakajima
Takashi Yokota
ResearchOpen Access30 Mar 2023
Scientific Reports

Volume: 13, P: 1-8
Learning curve of i-gel insertion in novices using a cumulative sum analysis

Toshiyuki Nakanishi
Seishi Sakamoto
Takashi Toriumi
ResearchOpen Access02 May 2023
Scientific Reports

Volume: 13, P: 1-8
In-frame deletion variant of ABCD1 in a sporadic case of adrenoleukodystrophy

Takashi Matsukawa
Atsushi Sudo
Tatsushi Toda
ResearchOpen Access28 Feb 2025
Human Genome Variation

Volume: 12, P: 1-4
MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1

The scavenger receptor MSR1 contributes to the clearance of damage-associated molecular patterns (DAMPs) by infiltrating myeloid cells in the post-stroke rodent brain. Myeloid cell MSR1 deficiency impairs clearance and exacerbates stroke-induced impairments, whereas a pharmacological intervention to boost MSR1 expression improves pathological and functional outcomes.

Takashi Shichita
Minako Ito
Akihiko Yoshimura
Research10 Apr 2017
Nature Medicine

Volume: 23, P: 723-732
Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages

Supercentenarians are approaching the current longevity limit by avoiding or surviving major illness, thus identifying biomarkers for exceptional survival might provide insights into the protection against disease of aging. Here, the authors show low NT-proBNP and high albumin in plasma are the biological correlates of survival to the highest ages.

Takumi Hirata
Yasumichi Arai
Nobuyoshi Hirose
ResearchOpen Access30 Jul 2020
Nature Communications

Volume: 11, P: 1-17
Real time monitoring of cold Ca²⁺ dependent transcription and its modulation by NCX inhibitors

Hsin-tzu Wang
Shiori Miyairi
Naohiro Kon
ResearchOpen Access15 Oct 2022
Scientific Reports

Volume: 12, P: 1-9
Noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and an overlapping disease

Whole-genome sequencing identifies noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and oculopharyngeal myopathy with leukoencephalopathy, three disorders with overlapping clinical features and neuroimaging findings.

Hiroyuki Ishiura
Shota Shibata
Shoji Tsuji
Research22 Jul 2019
Nature Genetics

Volume: 51, P: 1222-1232
Modulation of circadian clock by crude drug extracts used in Japanese Kampo medicine

Manhui Zhang
Kohei Kobayashi
Takashi Yoshimura
ResearchOpen Access26 Oct 2021
Scientific Reports

Volume: 11, P: 1-9
Diagnostic error rates and associated factors for lower gastrointestinal perforation

Taku Harada
Takashi Watari
Taro Shimizu
ResearchOpen Access19 Jan 2022
Scientific Reports

Volume: 12, P: 1-7
Intensive or standard blood pressure control in patients with a history of ischemic stroke: RESPECT post hoc analysis

A total of 1074 patients with a history of ischemic stroke enrolled in The Recurrent Stroke Prevention Clinical Outcome (RESPECT) Study were assigned to intensive blood pressure (BP) control group (blood pressure < 120/80 mmHg) or standard blood pressure control group (blood pressure < 140/90 mmHg) and were followed up for a mean of 3.9 years. Seventy-eight first recurrent strokes occurred, including 70 ischemic stroke and 8 intracerebral hemorrhage. Intensive treatment did not change annual risk of ischemic stroke (1.74% vs. 1.75%, P = 0.999), but markedly reduced risk of hemorrhagic stroke (0.00% vs. 0.39%, P = 0.005). Beneficial effect of intensive BP control were observed for risk of hemorrhagic stroke in the patients with a history of ischemic stroke.

Kazuo Kitagawa
Hisatomi Arima
Seigo Nakada
Research04 Mar 2022
Hypertension Research

Volume: 45, P: 591-601
Miuraenamides A and B, Novel Antimicrobial Cyclic Depsipeptides from a New Slightly Halophilic Myxobacterium: Taxonomy, Production, and Biological Properties

Takashi Iizuka
Ryosuke Fudou
Makoto Ojika
Research01 Jul 2006
The Journal of Antibiotics

Volume: 59, P: 385-391
CD8⁺ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

In these new reports, three different research groups independently find that various T cell populations are crucial mediators of obesity-induced metabolic dysfunction. They also show that pharmacological approaches that target these T cells are beneficial, thus opening the door to possible new therapeutic approaches to treating obesity-related diseases such as diabetes (pages 846–847, 921–929 and 930–939).

Satoshi Nishimura
Ichiro Manabe
Ryozo Nagai
Research26 Jul 2009
Nature Medicine

Volume: 15, P: 914-920
Intensive treat-to-target statin therapy and severity of diabetic retinopathy complicated by hypercholesterolaemia

Tomoaki Murakami
Satoshi Kato
Nagahisa Yoshimura
Research26 Oct 2020
Eye

Volume: 35, P: 2221-2228
Loss-of-function variants in NEK1 are associated with an increased risk of sporadic ALS in the Japanese population

Hiroya Naruse
Hiroyuki Ishiura
Shoji Tsuji
Research12 Sept 2020
Journal of Human Genetics

Volume: 66, P: 237-241
Autonomous oil flow generated by self-oscillating polymer gels

Kyosuke Yoshimura
Yuji Otsuka
Shingo Maeda
ResearchOpen Access30 Jul 2020
Scientific Reports

Volume: 10, P: 1-7
Personal identification with orthopantomography using simple convolutional neural networks: a preliminary study

Shinpei Matsuda
Takashi Miyamoto
Tatsuhito Hasegawa
ResearchOpen Access11 Aug 2020
Scientific Reports

Volume: 10, P: 1-7
Multi-species coexistence in Lotka-Volterra competitive systems with crowding effects

Maica Krizna A. Gavina
Takeru Tahara
Jin Yoshimura
ResearchOpen Access19 Jan 2018
Scientific Reports

Volume: 8, P: 1-8
Cholecystokinin induces crowing in chickens

Tsuyoshi Shimmura
Mai Tamura
Takashi Yoshimura
ResearchOpen Access08 Mar 2019
Scientific Reports

Volume: 9, P: 1-7
Territory holders and non-territory holders in Ayu fish coexist only in the population growth process due to hysteresis

Yuki Katsumata
Takashi Uehara
Genki Ichinose
ResearchOpen Access01 Dec 2017
Scientific Reports

Volume: 7, P: 1-7
Activation of endogenous arginine vasopressin neurons inhibit food intake: by using a novel transgenic rat line with DREADDs system

Mitsuhiro Yoshimura
Kazuaki Nishimura
Yoichi Ueta
ResearchOpen Access16 Nov 2017
Scientific Reports

Volume: 7, P: 1-10
Asymptotic stability of a modified Lotka-Volterra model with small immigrations

Takeru Tahara
Maica Krizna Areja Gavina
Jin Yoshimura
ResearchOpen Access04 May 2018
Scientific Reports

Volume: 8, P: 1-7
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Mu rhythm suppression reflects mother-child face-to-face interactions: a pilot study with simultaneous MEG recording

Chiaki Hasegawa
Takashi Ikeda
Mitsuru Kikuchi
ResearchOpen Access10 Oct 2016
Scientific Reports

Volume: 6, P: 1-8
Microhabitat locality allows multi-species coexistence in terrestrial plant communities

Jerrold M. Tubay
Keisuke Suzuki
Jin Yoshimura
ResearchOpen Access20 Oct 2015
Scientific Reports

Volume: 5, P: 1-9
A unique mechanism of successful fertilization in a domestic bird

Tomohiro Sasanami
Shunsuke Izumi
Kazuyoshi Tsutsui
ResearchOpen Access09 Jan 2015
Scientific Reports

Volume: 5, P: 1-7
FR177391, A New Anti-hyperlipidemic Agent from Serratia

Makiko Yamaoka
Kentaro Sato
Hidenori Nakajima
Research01 Oct 2005
The Journal of Antibiotics

Volume: 58, P: 654-662
Elevated Plasma Brain Natriuretic Peptide Levels Independent of Heart Disease in Acute Ischemic Stroke: Correlation with Stroke Severity

Hirofumi Tomita
Norifumi Metoki
Ken Okumura
Research01 Sept 2008
Hypertension Research

Volume: 31, P: 1695-1702
Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests

Shizufumi Ebihara and colleagues report the identification of Usp46 as a quantitative trait gene underlying mouse behavior in the tail suspension and forced swimming tests, which are widely used for assessing depression-like behavior. Usp46 encodes a ubiquitin-specific peptidase.

Shigeru Tomida
Takayoshi Mamiya
Shizufumi Ebihara
Research24 May 2009
Nature Genetics

Volume: 41, P: 688-695
Non-fasting and fasting serum triglyceride concentrations and new-onset hyperuricemia in the general Japanese population: ISSA-CKD study

Takashi Sakaguchi
Shunsuke Funakoshi
Hisatomi Arima
ResearchOpen Access17 Feb 2025
Scientific Reports

Volume: 15, P: 1-8
Evolution of periodicity in periodical cicadas

Hiromu Ito
Satoshi Kakishima
Jin Yoshimura
ResearchOpen Access14 Sept 2015
Scientific Reports

Volume: 5, P: 1-10
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

The spike protein of the Omicron variant of SARS-CoV-2 has a higher affinity for ACE2 than Delta, and a marked change in its antigenicity increases Omicron’s evasion of therapeutic and vaccine-elicited neutralizing antibodies.

Bo Meng
Adam Abdullahi
Ravindra K. Gupta
ResearchOpen Access01 Feb 2022
Nature

Volume: 603, P: 706-714
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Discovery, characterization and functional improvement of kumamonamide as a novel plant growth inhibitor that disturbs plant microtubules

Takashi Ishida
Haruna Yoshimura
Hayato Ishikawa
ResearchOpen Access23 Mar 2021
Scientific Reports

Volume: 11, P: 1-13
Effects of Renin-Angiotensin System Blockade on Macrophage Infiltration in Patients with Hypertensive Nephrosclerosis

Toshihiko Imakiire
Yuichi Kikuchi
Soichiro Miura
Research01 Jul 2007
Hypertension Research

Volume: 30, P: 635-642
The DNA-binding inhibitor Id3 regulates IL-9 production in CD4⁺ T cells

The molecular mechanisms that lead to T_H9 differentiation remain unclear. Chen and colleagues show that TGF-β- and IL-4-induced downregulation of the transcriptional repressor Id3 is required for T_H9 differentiation.

Hiroko Nakatsukasa
Dunfang Zhang
WanJun Chen
Research31 Aug 2015
Nature Immunology

Volume: 16, P: 1077-1084
Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes

Hideki Yashiroda
Tsunehiro Mizushima
Keiji Tanaka
Research17 Feb 2008
Nature Structural & Molecular Biology

Volume: 15, P: 228-236
Microwave-assisted C–C bond formation of diarylacetylenes and aromatic hydrocarbons on carbon beads under continuous-flow conditions

The synthesis of polycyclic aromatic compounds generally requires stoichiometric oxidants or homogeneous metal catalysts, however, the risk of contamination of inorganic residues can affect their properties. Here, the authors develop a microwave-assisted platinum on beaded activated carbon-catalyzed C–C bond formation of aromatic compounds under continuous-flow conditions.

Tsuyoshi Yamada
Wataru Teranishi
Hironao Sajiki
ResearchOpen Access24 Apr 2023
Communications Chemistry

Volume: 6, P: 1-11
Mal-function of TLRs by SOCS

Suppressor of cytokine signaling 1 has been linked to the negative regulation of Toll-like receptor signaling. The mechanism for this seems to be suppressor of cytokine signaling 1–mediated degradation of the adaptor Mal, which is required for Toll-like receptor signaling.

Takashi Kobayashi
Giichi Takaesu
Akihiko Yoshimura
News & Views01 Feb 2006
Nature Immunology

Volume: 7, P: 123-124
Neutralizing immunity against coronaviruses in Tanzanian health care workers

Godfrey Barabona
Isaac Ngare
Takamasa Ueno
ResearchOpen Access06 Mar 2024
Scientific Reports

Volume: 14, P: 1-10
Impact of aspirin on biochemical recurrence of prostate cancer after robot assisted radical prostatectomy in a multicenter retrospective cohort study

Shuhei Suzuki
Hiromitsu Negoro
Takashi Kobayashi
ResearchOpen Access15 Jan 2025
Scientific Reports

Volume: 15, P: 1-10
Mechanistic basis of pre–T cell receptor–mediated autonomous signaling critical for thymocyte development

Sho Yamasaki
Eri Ishikawa
Takashi Saito
Research04 Dec 2005
Nature Immunology

Volume: 7, P: 67-75
Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples

Ying Liu
Kimio Yoshimura
Shoichiro Tsugane
Research01 Feb 2005
Journal of Human Genetics

Volume: 50, P: 62-68
A randomised phase II trial of S-1 plus cisplatin versus vinorelbine plus cisplatin with concurrent thoracic radiotherapy for unresectable, locally advanced non-small cell lung cancer: WJOG5008L

Tomonari Sasaki
Takashi Seto
Yoichi Nakanishi
ResearchOpen Access12 Sept 2018
British Journal of Cancer

Volume: 119, P: 675-682

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