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Single-cell RNA sequencing, whole-exome sequencing and spatial transcriptome sequencing of gallbladder adenocarcinomas from 75 patients stratifies the disease into groups with distinct clinical outcomes.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

A stereotaxic atlas of the whole mouse brain, based on a Nissl-stained cytoarchitecture dataset with isotropic 1-μm resolution, achieved through continuous micro-optical sectioning tomography, promises to be a versatile brainsmatics tool for studying the whole brain at single-cell level.

Proteome profiling of plasma samples in human pan-cancer cohorts reveals patterns of biomarkers for diagnosis.

The effects of non-reacting components on polyatomic reactions are still largely unclear. Here, the authors show through a combined experimental and theoretical study of the D + CH₄ reaction that the CH₃ umbrella bending mode serves as a reporter mode, revealing how the D atom dynamically approaches CH₄.

While entangled networks can offer improved mechanical performance in synthetic materials, these can be challenging to achieve in polymer materials. Here, the authors report a co-initiating system for fabrication of printable entangled networks.

Tanycytic insulin receptors allow insulin access to the hypothalamic arcuate nucleus and are relevant for driving AgRP neuronal activity in response to feeding.

Electrolyte interactions critically govern battery performance yet lack precise design principles. The authors introduce interaction motif descriptors to design an electrolyte enabling 99.7% Li-metal Coulombic efficiency for 4.5 V batteries.

Electronic metal-support interaction within Pd/TiO₂ are optimized for photocatalytic H₂O₂ evolution and furfural oxidation to furoic acid, realizing the simultaneous utilization of photogenerated electrons and holes for dual value-added products.

Tao et al. study the role of TRMT6 in colorectal cancer, where it is upregulated and show that TRMT6 supports histone biosynthesis by stabilizing tRNA-Lys-TTT-1-1. Targeting TRMT6 reduced histone mRNA translation in a codon-biased manner.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Lead-free piezoelectric ceramics typically face a trade-off between Curie temperature and piezoelectric response. Here, the authors demonstrate a stress engineering via BaAl₂O₄ incorporation in BaTiO₃-based ceramics simultaneously achieves high Curie temperature and piezoelectric response.

This study reveals that over half of China’s steel units lack sufficient renewable energy for hydrogen-based direct reduced iron technology. Aggressive deployment would increase carbon emissions, economic costs, and water usage in the steel sector.

The decades-old limit on how long human embryos can be grown in culture is under debate. A new road map outlines how to extend the length of culture responsibly.

The study proposes BayesDL-SIM, a Bayesian deep learning framework for structured illumination super-resolution microscopy. It improves reconstruction fidelity while enhancing the reliability of imaging results by quantifying uncertainties.

Vector magnetometers measure magnetic fields for diverse applications. Here, the authors present a high-resolution vector atomic magnetometer achieving precise field and angular measurements, addressing key metrology challenges while retaining the accuracy and calibration benefits of scalar sensors.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

This study presents an anionic high-entropy doping strategy, elucidating the intricate charges state regulation to drive dipole polarization-dominated dielectric loss and efficient electromagnetic wave absorption in thin graphite framework.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Here, the authors report immunogenicity and safety of AR-MPXV5, a penta-component mRNA vaccine, in naive and simian immunodeficiency virus infected nonhuman primates (NHPs), and demonstrate protection in naïve male NHPs after immunization with two doses of AR-MPXV5.

Hyperbolic shear polaritons (HShPs) are strongly confined light-matter excitations that have been previously observed in low-symmetry 3D materials with limited tunability. Here, the authors report the observation and manipulation of HShPs in twisted bilayers α-MoO₃ by tuning the sample structure or using a graphene electrostatic gate.

In this work, the authors present a metasurface-based wide-angle beam splitter designed for future applications in optical wireless communication. By leveraging the metasurface polarization multiplexing and wavelength division multiplexing properties, they achieved a high-performance optical wireless communication system, possessing a Tbps communication rate, more than 120° coverage range, and up to 144 users parallel communication capabilities.

This study uses high-spatiotemporal-resolution synchrotron X-ray microscopy to reveal unexpected acoustic loss in surface acoustic wave resonators. Findings show that non-uniform excitation causes energy leakage, providing insights for optimizing future wireless communication devices

High-throughput screening identifies opioid compounds and prodynorphin-derived peptide agonists of the G-protein-coupled receptor MRGPRX2 and informs a homology model that is used for in silico screening to find a small-molecule probe that provokes degranulation in mast cells, which express this receptor.

The transport behaviour of strange metals is distinct from weakly interacting Fermi liquids. Now, a large thermoelectric response has been shown at the transition between those two states.

The synthesis of acenaphthylene-containing polycyclic aromatic hydrocarbons has traditionally required multiple sequential synthetic steps, limiting structural diversity. Herein, the authors present a tandem C−H penta- and hexaannulation reaction of aryl alkyl ketone with acetylenedicarboxylate.

The production of higher alcohols is very valuable because of their high volumetric energy density. Now, Sargent, Sinton and co-workers report the design of copper nanoparticles with tailored nanocavities that promote n-propanol formation by the coupling of C2 and C1 intermediates inside the cavity.

A gap-free telomere-to-telomere genome assembly for a ram of Hu sheep uncovers genes and variants associated with domestication and selection for wool fineness.