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Bipolar conductivity is fundamental for electronic devices based on two-dimensional semiconductors. Here, the authors report on-demand p- and n-doping of monolayer MoS₂ via defects engineering using thermochemical scanning probe lithography, and achieve a p-n junction with rectification ratio over 10⁴.

The incorporation of the desirable properties of graphene into three-dimensional materials remains challenging. Here, the authors report the scalable self-assembly of graphene sheets into spongy materials with very low densities, and near-zero and largely strain-independent Poisson's ratios in all directions.

How subgenome-divergent and -convergent transcription is mediated and harmonized in hexaploid common wheat genome remains unclear. Here, via characterizing the cistrome maps, the authors reveal that transposon elements with transcription factor binding ability have the potential to make the contribution.

Association analyses using resting-state functional magnetic resonance images identify common genetic variants influencing intrinsic brain activity. Variation in brain function is genetically correlated with several neuropsychiatric traits.

Li et al. define an adaptive resistance mechanism against FGFR inhibitor treatment in breast cancer attributed to loss of BRG1 chromatin recruitment, reactivation of YAP-dependent enhancers and upregulation of amino acid-induced mTORC1 activity.

Highly ordered and compositionally complex ceramics are prone to disordering under irradiation, but exactly how is unclear. Here, the authors use high resolution microscopy to directly image the order-to-disorder phase transformations in Ti₃AlC₂ into otherwise unattainable solid solutions.

Conventional theories for interfacial thermal transport are derived from bulk phonon properties. Here, the authors report experimental observation of interfacial phonon modes localized at interfaces, changing how interfacial thermal transport should be understood.

The observation of macroscopic and direct light propulsion of bulk-graphene-based material offers an exciting opportunity for realizing long-sought proposals in areas such as space transportation driven directly by sunlight.

The synthesis of catharanthine, the direct precursor of anticancer drugs vinblastine and vincristine, is challenging due to its structural complexity. Here synthetic biology enables the construction of a Pichia pastoris cell factory for the biosynthesis and potentially scalable production of catharanthine from simple carbon sources.

The lack of appropriate models restricts pre-clinical research for nasopharyngeal carcinoma (NPC). Here the authors report the development and characterization of NPC patient-derived xenografts (PDXs), and EBV positive NPC cell line from patient tumor, and suggest their potential use in future NPC research.

Pseudomonas aeruginosa quorum-sensing signal N-(3-oxo-dodecanoyl) homoserine lactone alters host cell membranes and induces host cell death via ligand-independent immune receptor ligation.

Ferroelectric/antiferroelectric phase boundary is both technologically and scientifically important. Here, the authors reveal the structure of intermediate phase involved in classical Pb(Zr_1-xTi_x)O₃.

Optoelectronic oscillators (OEOs) are used to generate low-noise microwave oscillations for many technologies but typically operate in a limited frequency range. Here the authors present an OEO that takes advantage of random distributed feedback and an open cavity structure to produce ultra-wideband random microwave signals.

Organ regeneration by transplantation of ESC/iPSC-derived tissues is a promising but still challenging approach. Here Lin et al. show that liver damage caused by a chemical insult induces not only fibrosis but also Lgr5⁺ cell expansion that can be further promoted by treatment with HGF/R-spondin1.

With a design inspired by wind-dispersed seeds, a series of three-dimensional passive fliers at the macro-, meso- and microscale are realized that can bear active electronic payloads.

Ji and colleagues demonstrate that metabolic reprogramming in SCLC underlies chemotherapy resistance, resulting in an actionable dependency on the mevalonate pathway in tumor cells, which can be targeted using statins to revert chemoresistance.

Chen et al. describe a new subtype of reactive astrocyte formed by APOE-mediated lipid accumulation in individuals with epilepsy and mouse models. These reactive astrocytes aggravate seizure symptoms and could serve as new therapeutic targets for epilepsy.

Structural superlubricity (SSL) is a state of nearly zero friction and no wear between two contacted solid surfaces. Here, authors show that, by preventing edge contact with the substrate, a microscale graphite flake can achieve robust SSL against nanostructured silicon surfaces under ambient condition.

Analyses of data from high-throughput genomic technologies are challenging given large data dimensionality. Here, Liu and colleagues describe a method called MANCIE (Matrix Analysis and Normalization by Concordant Information Enhancement) that can conduct genomic data normalization and bias correction to detect biologically relevant information.

Authors analyze the potential of biochar in China, revealing it could sequester up to 0.92 billion tons of CO₂ per year with an average net cost of US$90 per ton of CO₂ in a sustainable manner, supporting carbon neutrality goal by 2060.

The large family PbZrO₃-based solid solutions are usually considered as antiferroelectric materials with specific antiparallel polarization configuration. Here, the authors demonstrate the PbZrO₃-based material has ferrielectric dipoles ordering and configure a clear structure-property relationship.

One way to improve the performance of supercapacitors is to use hybrid carbon nanomaterials. Here the authors show a bioinspired electrode design with graphene petals and carbon nanotube arrays serving as leaves and branchlets, respectively. The structure affords excellent electrochemical characteristics.

Polymers compared to structural materials usually have low strength and thermal conductivity. Here the authors show a fabrication method to form bio-compatible crystalline polyethylene nanofibers that exhibit ultra-high strength, thermal conductivity and electrical insulation.

Water electrolysis can generate carbon-neutral hydrogen gas from water, yet the required catalysts are often expensive, scarce, and poor at gas release. Here, the authors prepared nitrogen-doped carbon tungstide nanoarrays with high water-splitting activities and bubble-releasing surfaces.

Receptor tyrosine kinases are often activated in malignant gliomas. Here, the authors develop a dual functionalized brain targeting nano-inhibitor to simultaneously target EGFR and MET pathways, and show this can overcome temozolomide resistance in glioma.

Long non-coding RNAs are identified using a high-throughput paired-guide RNA genomic deletion screen.