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Showing 1–9 of 9 results
Advanced filters: Author: Terrence T.-T. Yuen Clear advanced filters

  • A study reports on the antigenic characterization of SARS-CoV-2 BA.1, BA.1.1 and BA.2 and the neutralizing activity of different monoclonal antibodies and sera against them.

    • Sho Iketani
    • Lihong Liu
    • David D. Ho
    ResearchOpen Access
    Nature
    Volume: 604, P: 553-556

  • The B.1.1.529/Omicron variant of SARS-CoV-2 is resistant to neutralization by serum not only from patients who recovered from COVID-19, but also from individuals vaccinated with one of the four widely used COVID-19 vaccines.

    • Lihong Liu
    • Sho Iketani
    • David D. Ho
    Research
    Nature
    Volume: 602, P: 676-681

  • Protective immunity against SARS-CoV-2 relies on both antibodies and a T cell dependent response, however, direct experimental evidence for the contribution of cellular immunity is limited. Here authors present a mouse model that is susceptible to SARS-CoV-2 and lacks B cells to demonstrate the emergence of efficient cellular immune response against SARS-CoV-2 upon vaccination or viral challenge.

    • Xiaolei Wang
    • Terrence Tsz-Tai Yuen
    • Jian-Dong Huang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Here, using lung epithelial cells and ex vivo tissue explants, the authors show that, in addition to ACE2, host heparan sulfate is directly involved in SARS-CoV-2 attachment and entry and provide data suggesting that host sialic acids may act as viral restriction factor in lung tissues.

    • Hin Chu
    • Bingjie Hu
    • Kwok-Yung Yuen
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Although extrapulmonary complications of different organ systems are recognized in patients with severe COVID19 effects are less well studied. Here, Qiao et al. characterize the pathogenesis of SARS-CoV-2 on bone metabolism in Syrian hamster and find that bone loss is associated with virus-mediated cytokine dysregulation.

    • Wei Qiao
    • Hui En Lau
    • Kelvin Wai-Kwok Yeung
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16