Search

Morphological studies and phylogenetic analyses based on the newly discovered Early Cretaceous eutherian mammal Ambolestes zhoui show that the oldest purported metatherian Sinodelphys is instead a eutherian.

The study reveals how bortezomib activates Mycobacterium tuberculosis Clp protease complexes. Cryo-EM structures reveal how sub-stoichiometric bortezomib binding triggers structural changes, mediates holoenzyme formation and disrupts Clp system regulation.

The exact role of the degenerate nucleotide-binding site in a heterodimeric ABC transporter is unclear. Here, authors identify a mycobacterial isoniazid efflux pump, capture its asymmetric intermediate states and reveal mechanism of this transporter mediated by the degenerate site.

Smoking-associated DNA methylation changes in whole blood have been reported by many EWAS. Here, the authors use a cell-type deconvolution algorithm to identify cell-type specific DNA methylation signals in seven EWAS, identifying lineage-specific smoking-associated DNA methylation changes.

Engineered symbiotic bacteria with blood-induced secretion of multiple effectors effectively inhibit malaria and arbovirus (Dengue and Zika) infections in mosquitoes, providing a promising strategy to combat concurrent transmission of these diseases.

The controlled synthesis of monodisperse nanospheres faces a number of difficulties, such as extensive crosslinking during hydrothermal processes. Here, the authors show a route for the controlled synthesis of mesoporous polymer nanospheres, which can be further converted into carbon nanospheres through carbonization.

The authors reveal nearly two-order magnitude of decoupling of the mean free path of the dominant electrons to that of phonons in Bi-Sb alloy, achieving an atomically homogeneous, coarse-grained sample through ultrafast quenching, enabling thermoelectric cooling down to the liquid nitrogen regime.

A bimolecular doping strategy enables the realisation of white organic polarized emissive semiconductor single crystals, emitting white light with a maximum degree of polarization as high as 0.96. Organic polarized light-emitting diodes and light-emitting transistors with tuneable emission wavelength are also demonstrated.

The global regulator PhoP plays crucial roles in bacterial pathogenicity. Shi et al. report four cryo-EM structures of PhoP-dependent transcription activation and repression complexes, revealing dual transcription regulation mechanisms of PhoP.

Here, four cryo-EM structures of Mtb OppABCD reveal an assembly of a cluster C substrate-binding protein and its translocator, as well as the [4Fe–4S] cluster-regulated transport mechanism of oligopeptide permeases found in bacteria.

A knowledge gap persists between machine learning developers and clinicians. Here, the authors show that the Advanced Data Analysis extension of ChatGPT could bridge this gap and simplify complex data analyses, making them more accessible to clinicians.

Deep learning for medical image analysis is a promising new avenue to predict treatment response, however the clinical application of these methods has been so far limited. Here, the authors propose a model to predict chemotherapy response in breast cancer in real world clinical settings.

Domain wall formation and propagation using a small electric voltage are demonstrated in ferro-rotational 1T-TaS₂, although the ferroic order does not couple with electromagnetic fields, providing an opportunity for the manipulation and application of ferro-rotational order.

Combination therapy for Buruli ulcer (BU) is suboptimal. Here, Liu et al. show that the candidate drug TB47 has potent bactericidal activity against Mycobacterium ulcerans in vitro and in a mouse model, which underscores its potential for shortening the course of BU and treating other mycobacterial diseases.

This study of Chinese endometrioid endometrial carcinomas describes the proteogenomic differences between early-onset and late-onset tumors, finding that SIGLEC10 mutation may contribute to tumorigenesis and progestin resistance in early cases.

The role of the nucleolus in cell fate is not well known. Here the authors show nucleolar integrity maintained by rRNA-mediated liquid-liquid phase separation and 3D chromatin structure of perinucleolar heterochromatin regulates the fate transition of mouse embryonic stem cells to 2 cell-stage embryo-like cells, and that rRNA biogenesis regulates the 2-cell-to-4-cell transition of development.

The role of nucleolar phase separation in stem cell fate decision is not well understood. Here, the authors show that the nucleolus-localized LIN28A protein undergoes LLPS in mESCs and in vitro, and that pluripotency state conversion depends on this phase separation capacity.

The sperm flagellum is composed of tubulin-based microtubules and is critical for sperm motility and thus male fertility. Here, the authors show that STYXL1 regulates CCT complex-facilitated tubulin folding and is essential for sperm flagella formation.

The mechanisms regulating Tat function for HIV-1 replication remain poorly understood. Here, the authors reveal that the transcriptional activity of Tat is modulated by a PRMT2-licensed switch between its nucleolar sequestration and phase separation into the nucleoplasmic Super Elongation Complex (SEC) droplets.

Induced pluripotent stem cell (iPSC)-derived macrophages (iMACs) are being used to make chimeric antigen receptor (CAR) macrophages for immunotherapy. Here the authors design a second-generation macrophage-specific CAR by integrating CD3ζ and toll/IL-1R (TIR) domains resulting in an M1-polarized CAR-iMAC with increased antitumor functions.

Supports can largely affect the catalytic performance of metal nanoparticles, but the underlying principles are not yet fully understood. Here the authors demonstrate that metal-support interfacial compatibility of Ru/TiO₂ can critically control the metal-support interaction modes and the catalytic performances in CO₂ hydrogenation.

The sources and sinks of Re and U in the modern ocean may be imbalanced, according to sedimentary porewater analysis and assessment of reductive Re and U removal on the continental shelf

Structural studies on the complex containing G-protein-coupled receptor kinase 2 (GRK2), neurotensin receptor 1 (NTSR1), Gα_q and the arrestin-biased ligand SBI-553 provide insights into these interactions and a foundation for the design of arrestin-biased ligands for G-protein-coupled receptors.

A chemoproteomic method was developed that enables the global discovery of metal-binding proteins (MBPs) in proteomes, where the thermal stability of MBPs is perturbed by metal chelators. This tool, called METAL-TPP, is used to discover MBP candidates in the human proteome and provides a valuable method for functional annotation of MBPs in cell biology.

Endothelin receptors (ETAR and ETBR) are critical for vasoregulation and are targets for cardiovascular diseases treatment. Here, the authors offer a structural basis for peptide recognition selectivity and activation of both endothelin receptors.

The thermoelectric material Mg₃Bi₂ is shown to be ductile in single-crystal form along certain directions, with a room-temperature tensile strain of 100%, which is attributed to the gliding of dislocations.

Population analysis of 516 wild and domesticated broomcorn millet genomes and a graph-based pangenome based on de novo assemblies of 32 representative accessions identify genomic variations associated with domestication traits.

Monochromatic electron energy-loss spectroscopy enables the observation of highly confined and ultraslow hyperbolic phonon polaritons in suspended monolayer hexagonal boron nitride, expanding the potential of van der Waals materials for nanophotonic applications.

Analysis of 4,578 Mycobacterium tuberculosis isolates reveals the evolutionary history of the four tuberculosis genotypes in China, from emergence 1,000 years ago to expansion, population peaks and, more recently, dominance of the indigenous sublineage L2.3.

Zhou et al. use multimodal brain imaging measures to describe the neural dynamics of same-race and other-race facial categorization. The resulting dynamic neural activity predicts racial biases in facial recognition and altruistic intention.

Organic functionalities are often introduced into conductive polymers for battery applications, but their addition also leads to conflicting properties and battery performance deterioration. Here the authors develop hierarchically ordered structures in conductive polymers that display exceptional electrochemical properties as a silicon binder.

A novel multispectral smart window achieves dynamic light modulation and robust microwave shielding.

During intergroup conflict, decision-makers must often consider whether their actions will harm noncombatant members of the outgroup. Here, Han et al. examine cognitive and neural processes during ‘collateral damage’ scenarios, revealing decreased avoidance of harm to outgroup civilians when conflict escalates.