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Cytoplasmic stress granules (SG) regulate cell fate and are involved in several physiological and pathological processes. Here, using mouse models of allergic rhinitis (AR), the authors reveal the formation of SGs within macrophages of the nasal mucosa and implicate SGs in the regulation of Lrp1-mediated efferocytosis and Type 2 cytokine production, aggravating AR symptoms.

Morphological studies and phylogenetic analyses based on the newly discovered Early Cretaceous eutherian mammal Ambolestes zhoui show that the oldest purported metatherian Sinodelphys is instead a eutherian.

The MmpL5/MmpS5 efflux system is crucial for drug extrusion and siderophore export in M. tuberculosis. Here, the authors report its high-resolution cryo-EM structures, revealing a unique trimeric assembly and a flexible extracellular stalk.

An implantable hydrogel-based phononic crystal that deforms with the surrounding tissues modifying the ultrasonic bandgap allows continuous and wireless monitoring of internal tissue strains.

The exact role of the degenerate nucleotide-binding site in a heterodimeric ABC transporter is unclear. Here, authors identify a mycobacterial isoniazid efflux pump, capture its asymmetric intermediate states and reveal mechanism of this transporter mediated by the degenerate site.

Here, four cryo-EM structures of Mtb OppABCD reveal an assembly of a cluster C substrate-binding protein and its translocator, as well as the [4Fe–4S] cluster-regulated transport mechanism of oligopeptide permeases found in bacteria.

Rooftop photovoltaic systems are often seen as a niche solution for mitigation but could offer large-scale opportunities. Using multi-source geospatial data and artificial intelligence techniques, the authors map their potential for reducing global temperatures and analyse regional differences.

Determining the size of critical nuclei remains challenging. Here the authors propose a method to determine the size of critical secondary nuclei on growth faces of poly(butylene succinate) single crystals in solution, using the probability of statistically selecting crystallizable units in random copolymers.

A small-molecule agonist of transient receptor potential cation channel subfamily M member 4 persistently activates the ion channel and induces necrosis characterized by sodium overload.

A millimetre-scale bioresorbable optoelectronic system with an onboard power supply and a wireless, optical control mechanism is developed for general applications in electrotherapy and specific uses in temporary cardiac pacing.

The authors reveal nearly two-order magnitude of decoupling of the mean free path of the dominant electrons to that of phonons in Bi-Sb alloy, achieving an atomically homogeneous, coarse-grained sample through ultrafast quenching, enabling thermoelectric cooling down to the liquid nitrogen regime.

The keeled sternum is a distinct skeletal element in extant birds. In this study, specimens of juvenile extinct birds—Enantiornithes—from the Early Cretaceous show a unique sequence of development in the sternum, suggesting differences between living birds and this extinct clade.

The controlled synthesis of monodisperse nanospheres faces a number of difficulties, such as extensive crosslinking during hydrothermal processes. Here, the authors show a route for the controlled synthesis of mesoporous polymer nanospheres, which can be further converted into carbon nanospheres through carbonization.

Luo et al. show in zebrafish and mouse that, upon intrahepatic biliary duct damage, gallbladder smooth muscle cells migrate to the common hepatic duct, where they produce retinoic acid to promote regeneration of the intrahepatic biliary duct.

The site-specific DNA inversion system is a versatile tool for genetic engineering. Here, authors developed a multiplexed DNA inversion system, Rci51-5/multi-sfxa101, in eukaryotes, facilitating promoter substitution for metabolic engineering applications.

A bioresorbable, wireless hydrogel (metagel) sensor, encompassing both biodegradable and stimulus-responsive hydrogels for ultrasonic monitoring of intracranial signals, was implanted into intracranial space with a puncture needle and deformed in response to physiological environmental changes.

Edge-exposed exfoliation using sticky tape is shown to be a simple and reliable method for scaling up the production of ultrathin, ultraflat and ultraflexible polycrystalline diamond membranes for diverse electrical, optical, mechanical, thermal, acoustic and quantum applications.

A high-quality reference genome assembly of cauliflower C-8 (V2) and genomic analyses of 971 diverse accessions and their relatives reveal the stepwise domestication and the genetic mechanism of curd biogenesis.

Designing superelastic materials with high critical stress, large recovery strain and temperature-independent modulus is desired but challenging. Here, the authors achieve these properties in a high-entropy alloy with multi-scale heterogeneities.

Dense calcium imaging combined with co-registered high-resolution electron microscopy reconstruction of the brain of the same mouse provide a functional connectomics map of tens of thousands of neurons of a region of the primary cortex and higher visual areas.

Multiomic analysis of cervical squamous cell carcinoma identifies distinct cellular ecosystems characterized by immune cell infiltration, heterotypic signaling and patient outcomes.

Using normal and Josephson scanning tunnelling microscopy, chiral kagome superconductivity modulations with corresponding residual Fermi arcs are detected in KV₃Sb₅ and CsV₃Sb₅.

Host defense peptide (HDP)-mimicking polymers are promising therapeutic alternatives. Here, the authors develop an AI-guided framework, and synthesize a polymer DM_0.8iPen_0.2, which exhibits broad-spectrum and potent antibacterial activity.

A prophylactic cancer vaccine consisting of commercial adjuvants wrapped by membranes from pluripotent stem cells inhibited tumour progression in mice, owing to shared antigens between tumour membranes and the pluripotent stem cell membranes.

A crystal structure of SARS-CoV-2 with inhibitor carmofur reveals the mechanism of action of this compound and opens the way to develop more potent drugs.

Formalin-fixed paraffin-embedded (FFPE) tissues constitute a vast and valuable patient material bank, but single nucleus RNAseq using such tissues is challenging. Here the authors develop a droplet-based method called snRandom-seq for high-throughput and sensitive single nucleus RNA-seq of FFPE samples.

A polymer-like ultrahigh-strength TiNi alloy was fabricated by a simple three-step process to give a combination of a polymer-like ultralow elastic modulus and a steel-like ultrahigh yield strength over a wide temperature range, and such exotic properties arise from a unique strain glass state.

The dynamics of planted forests in China over the past three decades have contributed ~1198tg of above-ground carbon storage.

Vascular access failure in subjects with chronic kidney diseases undergoing hemodialysis significantly reduces survival rates. Here, the authors introduce a portable device to detect early failure with high sensitivity and real-time thrombosis detection.

The authors use scanning tunnelling microscopy and muon spin resonance to demonstrate time-reversal symmetry-breaking superconductivity in Cs(V, Ta)₃Sb₅. The Cooper pairing in this state exhibits magnetism and is modulated by it.

Minimizing patient risk to thermal failure in wearable electronics typically requires complex circuit control, sensors, or passive materials. Here, Yoo et al. present an active materials system with a self-inflating bladder that delaminates upon excessive heat, mitigating the risk of thermal injury.

North Pacific dust flux and modelling results provide new evidence for long-term land-atmosphere-ocean interactions associated with the onset and intensification of the Northern Hemisphere Glaciation.

Sustainable methane oxidation has the potential to green the petrochemical industry. Here the authors demonstrate a cascade catalysis process involving photoconversion and then thermal decomposition at mild temperatures to form formaldehyde with a high selectivity and a high yield rate.

Population analysis of 516 wild and domesticated broomcorn millet genomes and a graph-based pangenome based on de novo assemblies of 32 representative accessions identify genomic variations associated with domestication traits.

Hydroxyl radicals (OH) determine the tropospheric self-cleansing capacity. This study reveals that reactive aldehyde chemistry plays an important role in OH formation and helps narrow the gap between ambient OH observations and model simulations.

Activated Notch signalling promotes cancer metastasis and stemness. Here the authors show that Notch1 activates transcription of DNA replication factor RCF4 and that RCF4 binds and stabilises Notch1 intracellular ___domain (NICD1) to promote cancer metastasis.

Here the authors have developed a superconducting microwave frequency comb that is fully integrated, easy to manufacture, and operates with ultra-low power consumption, and could significantly advance microwave photonics and quantum processor integration.

This work presents a general surface molecular tuning strategy to promote the electrochemical reduction of CO.

Combination therapy for Buruli ulcer (BU) is suboptimal. Here, Liu et al. show that the candidate drug TB47 has potent bactericidal activity against Mycobacterium ulcerans in vitro and in a mouse model, which underscores its potential for shortening the course of BU and treating other mycobacterial diseases.