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RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α

Loss of RNF20 is associated with aggressive cancer phenotypes. Here the authors show that Rnf20 haploinsufficiency leads to the formation of lung tumours due to defective DNA repair and HIF1α-mediated metabolic rewiring.

Hao Liu
Yongqin Tang
Gergana Dobreva
ResearchOpen Access28 May 2025
Nature Communications

Volume: 16, P: 1-22
Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR

Little is known on how solid tumours overcome growth inhibitory signals within its hypoxic microenvironment. Here Henze et al.show that oxygen sensor PHD3 is frequently lost in gliomas, and that this loss hyperactivates EGFR signaling to sustain tumour cell proliferation and survival in hypoxia.

Anne-Theres Henze
Boyan K. Garvalov
Till Acker
ResearchOpen Access25 Nov 2014
Nature Communications

Volume: 5, P: 1-12
PHD3 regulates EGFR internalization and signalling in tumours

PHD3 is a hypoxia-inducible prolyl hydroxylase that regulates stability of HIF-1. Here Garvalov et al.report a hydroxylase-independent role of PHD3 in gliomas as a scaffolding protein that promotes internalization and limits signalling of EGFR upon ligand binding, thus inhibiting growth in hypoxia.

Boyan K. Garvalov
Franziska Foss
Till Acker
ResearchOpen Access25 Nov 2014
Nature Communications

Volume: 5, P: 1-11
EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance

Ephrins are transmembrane proteins involved in cell-cell communication, and implicated in cancer cell growth and progression. Here, the authors show that EphrinB2 expression is reduced in glioma cells both by genetic and epigenetic alterations and under hypoxia, through a HIF1α-mediated direct regulation of ZEB2, which enhances invasion and anti-angiogenic resistance.

C. Depner
H. zum Buttel
A. Acker-Palmer
ResearchOpen Access29 Jul 2016
Nature Communications

Volume: 7, P: 1-15
Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

The protein ephrin-B2 is known to be upregulated during angiogenesis — the growth of new blood vessels — but its precise function has been unclear. Here it is shown that signalling through ephrin-B2 controls vessel sprouting. Mechanistically, ephrin-B2 seems to function in part by regulating the internalization of vascular endothelial growth factor receptors (VEGFRs). The results indicate that blocking ephrin-B2 signalling might be an alternative to blocking VEGFR function to disrupt angiogenesis in tumours.

Suphansa Sawamiphak
Sascha Seidel
Amparo Acker-Palmer
Research05 May 2010
Nature

Volume: 465, P: 487-491
DNA methylation-based classification of central nervous system tumours

An online approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups has been developed to help to improve current diagnostic standards.

David Capper
David T. W. Jones
Stefan M. Pfister
Research14 Mar 2018
Nature

Volume: 555, P: 469-474
Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction

Endothelial cells play a critical role in the adaptation of tissues to injury and show a remarkable plasticity. Here the authors show, using single cell sequencing, that endothelial cells acquire a transient mesenchymal state associated with metabolic adaptation after myocardial infarction.

Lukas S. Tombor
David John
Stefanie Dimmeler
ResearchOpen Access29 Jan 2021
Nature Communications

Volume: 12, P: 1-12
Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

Veerle Compernolle
Koen Brusselmans
Peter Carmeliet
Research10 Jun 2002
Nature Medicine

Volume: 8, P: 702-710
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration

Bert Oosthuyse
Lieve Moons
Peter Carmeliet
Research01 Jun 2001
Nature Genetics

Volume: 28, P: 131-138
Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions

Peter Carmeliet
Lieve Moons
M. Graziella Persico
Research01 May 2001
Nature Medicine

Volume: 7, P: 575-583
Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

Marion Krieg
Richard Haas
Karl H Plate
Research16 Nov 2000
Oncogene

Volume: 19, P: 5435-5443

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