Nature Search

Tubulin engineering by semi-synthesis reveals that polyglutamylation directs detyrosination

Microtubules carry patterns of post-translational modifications that are important for the regulation of key cellular processes. Now a semi-synthetic method facilitates the production of tubulins with defined post-translational modifications. Using these designer tubulins, polyglutamylation of α-tubulin is found to promote its detyrosination by enhancing the activity of the carboxypeptidase vasohibin/small vasohibin-binding protein.

Eduard Ebberink
Simon Fernandes
Charlotte Aumeier
Research29 Jun 2023
Nature Chemistry

Volume: 15, P: 1179-1187
One-step construction of circularized nanodiscs using SpyCatcher-SpyTag

Circularised nanodiscs (cNDs) are able to stabilise large lipid bilayer patches and are used for structural and functional studies. Current techniques to build cNDs have numerous steps and low yields; here the authors report a single step construction method using the SpyCatcher-SpyTag system.

Shanwen Zhang
Qian Ren
Huan Bao
ResearchOpen Access14 Sept 2021
Nature Communications

Volume: 12, P: 1-9
Scalable co-sequencing of RNA and DNA from individual nuclei

Building on a nucleosome-depletion strategy, DEFND-seq utilizes a droplet microfluidic platform to enable high-throughput co-profiling of DNA and RNA in single cells.

Timothy R. Olsen
Pranay Talla
Peter A. Sims
Research12 Feb 2025
Nature Methods

Volume: 22, P: 477-487
Neutralizing antibody to human rhinovirus 14 penetrates the receptor-binding canyon

Thomas J. Smith
Elaine S. Chase
Timothy S. Baker
Research26 Sept 1996
Nature

Volume: 383, P: 350-354
BTK regulates microglial function and neuroinflammation in human stem cell models and mouse models of multiple sclerosis

Bruton’s tyrosine kinase (BTK) is expressed in immune cells and microglia, where its role remains poorly understood. Here, the authors show that BTK modulates microglial neuroinflammatory pathways relevant to multiple sclerosis (MS) and report robust effects of BTK inhibition in human in vitro models and animal models of MS.

Ross C. Gruber
Gregory S. Wirak
Dimitry Ofengeim
ResearchOpen Access22 Nov 2024
Nature Communications

Volume: 15, P: 1-17
p47 is a cofactor for p97-mediated membrane fusion

Hisao Kondo
Catherine Rabouille
Graham Warren
Research03 Jul 1997
Nature

Volume: 388, P: 75-78
Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

Timothy C. Wang
Robert D. Cardiff
Emmett V. Schmidt
Research23 Jun 1994
Nature

Volume: 369, P: 669-671
Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing

Gnirke et al. present a bead-based method for capturing sequences of interest in the human genome for massively parallel sequencing. Using long, biotinylated RNA probes to pull down PCR-amplified DNA fragments, they demonstrate sequencing of 2.5 Mbs of exons in 1,900 genes.

Andreas Gnirke
Alexandre Melnikov
Chad Nusbaum
Research01 Feb 2009
Nature Biotechnology

Volume: 27, P: 182-189
Stress-induced oligomerization and chromosomal relocalization of heat-shock factor

J. Timothy Westwood
Joachim Clos
Carl Wu
Research31 Oct 1991
Nature

Volume: 353, P: 822-827
Peripheral organs control central neurogenesis in the leech

Carlos A. Baptista
Timothy R. Gershon
Eduardo R. Macagno
Research30 Aug 1990
Nature

Volume: 346, P: 855-858
A novel dimer configuration revealed by the crystal structure at 2.4 Å resolution of human interleukin-5

Michael V. Milburn
Anne M. Hassell
Timothy N. C. Wells
Research13 May 1993
Nature

Volume: 363, P: 172-176
Cryo-EM structure of human Pol κ bound to DNA and mono-ubiquitylated PCNA

Translesion Synthesis is a process that enables cells to overcome the deleterious effects of replication stalling caused by DNA lesions. Here the authors present a Cryo-EM structure of human Y-family DNA polymerase k (Pol k) bound to PCNA, P/T DNA and an incoming nucleotide; and propose a model for polymerase switching in which “carrier state” Pol k is recruited to PCNA.

Claudia Lancey
Muhammad Tehseen
Alfredo De Biasio
ResearchOpen Access19 Oct 2021
Nature Communications

Volume: 12, P: 1-14
p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells

Stefan Ambs
William G. Merriam
Curtis C. Harris
Research01 Dec 1998
Nature Medicine

Volume: 4, P: 1371-1376
Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

The protective efficacy of a single dose of adenovirus serotype 26 (Ad26) vector-based vaccine expressing the SARS-CoV-2 spike protein in non-human primates is demonstrated.

Noe B. Mercado
Roland Zahn
Dan H. Barouch
Research30 Jul 2020
Nature

Volume: 586, P: 583-588
Actin polymerization is induced by Arp 2/3 protein complex at the surface of Listeria monocytogenes

Matthew D. Welch
Akihiro Iwamatsu
Timothy J. Mitchison
Research16 Jan 1997
Nature

Volume: 385, P: 265-269
Reduction of fibronectin expression by intravitreal administration of antisense oligonucleotides

Sayon Roy
Kathy Zhang
Alexander Kabanov
Research01 May 1999
Nature Biotechnology

Volume: 17, P: 476-479
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Katherine A. Fitzgerald
Eva M. Palsson-McDermott
Luke A. J. O'Neill
Research06 Sept 2001
Nature

Volume: 413, P: 78-83
Analysis of transcription complexes and effects of ligands by microelectrospray ionization mass spectrometry

Theodore A. Craig
Linda M. Benson
Rajiv Kumar
Research01 Dec 1999
Nature Biotechnology

Volume: 17, P: 1214-1218
Generation of marker-free plastid transformants using a transiently cointegrated selection gene

Sebastian M J Klaus
Fong-Chin Huang
Hans-Ulrich Koop
Research18 Jan 2004
Nature Biotechnology

Volume: 22, P: 225-229
New components of the spliced leader RNP required for nematode trans-splicing

John A. Denker
David M. Zuckerman
Timothy W. Nilsen
Research06 Jun 2002
Nature

Volume: 417, P: 667-670
Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer

The mechanisms associated with Caveolin-1 (Cav-1) mediated metabolic changes in prostate cancer are unclear. Here, the authors show that Cav-1 promotes rewiring of cancer cell lipid metabolism towards a program of exogenous lipid scavenging and vesicle biogenesis that intersects with mitochondrial dynamics in prostate tumors.

Jody Vykoukal
Johannes F. Fahrmann
Timothy C. Thompson
ResearchOpen Access27 Aug 2020
Nature Communications

Volume: 11, P: 1-16
Cell cycle-dependent regulation of yeast telomerase by Ku

Timothy S Fisher
Andrew K P Taggart
Virginia A Zakian
Research07 Nov 2004
Nature Structural & Molecular Biology

Volume: 11, P: 1198-1205
2-Deoxy-D-glucose reduces epilepsy progression by NRSF-CtBP–dependent metabolic regulation of chromatin structure

Mireia Garriga-Canut
Barry Schoenike
Avtar Roopra
Research15 Oct 2006
Nature Neuroscience

Volume: 9, P: 1382-1387
Whole–genome characterization of chemoresistant ovarian cancer

Whole-genome sequencing of tumour and germline DNA samples from 92 patients with high-grade serous ovarian cancer identifies frequent gene breakages that inactivate the tumour suppressors RB1, NF1, RAD51B and PTEN, and contribute to chemotherapy resistance; acquired resistance was associated with diverse mechanisms such as reversions of germline BRCA1/2 mutations and overexpression of the drug efflux pump MDR1.

Ann-Marie Patch
Elizabeth L. Christie
David D. L. Bowtell
Research27 May 2015
Nature

Volume: 521, P: 489-494
Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41

A common susceptibility haplotype for renal cell carcinoma is located on chromosome 12p12.1. Here, the authors show that the variant rs7132434 alters binding of the AP-1 transcription factor, which increases the expression of BHLHE41in renal cells.

Pierre Bigot
Leandro M. Colli
Stephen J. Chanock
ResearchOpen Access07 Jul 2016
Nature Communications

Volume: 7, P: 1-10
Localization of dystrophin to postsynaptic regions of central nervous system cortical neurons

Hart G. W. Lidov
Timothy J. Byers
Louis M. Kunkel
Research27 Dec 1990
Nature

Volume: 348, P: 725-728
The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3

Periasamy Selvaraj
Marian L. Plunkett
Timothy A. Springer
Research26 Mar 1987
Nature

Volume: 326, P: 400-403
Translational genomics of osteoarthritis in 1,962,069 individuals

A genome-wide association study meta-analysis combined with multiomics data of osteoarthritis identifies 700 effector genes as well as biological processes with a convergent involvement of multiple effector genes; 10% of these genes express the target of approved drugs.

Konstantinos Hatzikotoulas
Lorraine Southam
Eleftheria Zeggini
ResearchOpen Access09 Apr 2025
Nature

Volume: 641, P: 1217-1224
On-patient medical record and mRNA therapeutics using intradermal microneedles

Intradermal microneedles for the co-delivery of mRNA and near-infrared fluorescent microparticles are used in combination with deep learning-based image analysis for the simultaneous administration of therapeutics and registry of patient information records into the skin.

Jooli Han
Maria Kanelli
Ana Jaklenec
ResearchOpen Access24 Feb 2025
Nature Materials

Volume: 24, P: 794-803
Elevated hydrostatic pressure promotes protein recovery from formalin-fixed, paraffin-embedded tissue surrogates

Carol B Fowler
Robert E Cunningham
Jeffrey T Mason
Research24 Dec 2007
Laboratory Investigation

Volume: 88, P: 185-195
Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapy

Oncolytic viruses, such as vesicular stomatitis virus (VSV), are a promising class of cancer therapeutics. Here the authors report that a mutation in the CSDE1 gene renders cancer cells resistant to VSV replication and oncolysis, but a mutation-derived escape-associated neoantigen could be exploited for immunotherapy against treatment-resistant tumors.

Timothy Kottke
Jason Tonne
Richard G. Vile
ResearchOpen Access26 Mar 2021
Nature Communications

Volume: 12, P: 1-15
Transgenic pigs produce functional human factor VIII in milk

Rekha K. Paleyanda
William H. Velander
Henryk Lubon
Research01 Oct 1997
Nature Biotechnology

Volume: 15, P: 971-975
Transcription of IAP endogenous retroviruses is constrained by cytosine methylation

Colum P. Walsh
J. Richard Chaillet
Timothy H. Bestor
Correspondence01 Oct 1998
Nature Genetics

Volume: 20, P: 116-117
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Versatile and on-demand biologics co-production in yeast

The ability to combine the production of multiple biologics into a single ‘on demand’ system could help in situations where resources are limited. Here the authors demonstrate a proof-of-concept approach for the co-production of three biologics, allowing singular, mixed and combination drug products.

Jicong Cao
Pablo Perez-Pinera
Timothy K. Lu
ResearchOpen Access08 Jan 2018
Nature Communications

Volume: 9, P: 1-13
DAXX drives de novo lipogenesis and contributes to tumorigenesis

Cancer cells have altered lipid metabolism. Here the authors show that DAXX promotes lipogenesis and tumorigenesis through interaction with SREBP1/2.

Iqbal Mahmud
Guimei Tian
Daiqing Liao
ResearchOpen Access12 Apr 2023
Nature Communications

Volume: 14, P: 1-20
Functional recognition of the 3′ splice site AG by the splicing factor U2AF³⁵

Shaoping Wu
Charles M. Romfo
Michael R. Green
Research16 Dec 1999
Nature

Volume: 402, P: 832-835
Poly(ADP-ribose) is required for spindle assembly and structure

Paul Chang
Myron K. Jacobson
Timothy J. Mitchison
Research02 Dec 2004
Nature

Volume: 432, P: 645-649
Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis

Xenium spatial transcriptomic profiling of pulmonary fibrosis characterizes cell composition dynamics and histopathological features associated with the disease.

Annika Vannan
Ruqian Lyu
Nicholas E. Banovich
ResearchOpen Access03 Feb 2025
Nature Genetics

Volume: 57, P: 647-658
Chemical- and photo-activation of protein-protein thiol-ene coupling for protein profiling

The thiol-ene coupling between an alkene and a thiol can be exploited for selective labelling of cysteine residues in protein profiling applications, however, the labelling of complex cell lysate mixtures is underexplored. Here, the authors explore thiol-ene activation in systems from chemical models to complex cellular milieus, using UV, visible wavelength and redox initiators.

André Campaniҫo
Marcin Baran
Joanna F. McGouran
ResearchOpen Access29 Jan 2025
Communications Chemistry

Volume: 8, P: 1-10
The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos

Edwina Wright
Murray R. Hargrave
Peter Koopman
Research01 Jan 1995
Nature Genetics

Volume: 9, P: 15-20
Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

Timothy E. Adams
Susan Alpert
Douglas Hanahan
Research15 Jan 1987
Nature

Volume: 325, P: 223-228
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

John C. Lee
Jeffrey T. Laydon
Peter R. Young
Research29 Dec 1994
Nature

Volume: 372, P: 739-746
Crystal structure of a yeast TFIIA/TBP/DNA complex

Song Tan
Yvonne Hunziker
Timothy J. Richmond
Research09 May 1996
Nature

Volume: 381, P: 127-134
Nanomechanical detection to empower robust monitoring of sepsis and microbial adaptive immune system-mediated proinflammatory disease

Kessarin Thanapirom
Walid Al-Akkad
Joseph W. Ndieyira
ResearchOpen Access02 Dec 2024
Scientific Reports

Volume: 14, P: 1-20
Somatic activating mutations in MAP2K1 cause melorheostosis

Melorheostosis is characterized by bone overgrowth and associated with pain and functional impairment. Here, the authors use whole exome sequencing to identify somatic mutations in MAP2K1 in affected bone of melorheostosis patients which is associated with increased proliferation but delayed differentiation of cultured osteoblasts.

Heeseog Kang
Smita Jha
Timothy Bhattacharyya
ResearchOpen Access11 Apr 2018
Nature Communications

Volume: 9, P: 1-12
BRCA1 signals ARF-dependent stabilization and coactivation of p53

Kumaravel Somasundaram
Timothy K MacLachlan
Wafik S El-Deiry
Research18 Nov 1999
Oncogene

Volume: 18, P: 6605-6614
Suppression of caveolin expression induces androgen sensitivity in metastatic androgen-insensitive mouse prostate cancer cells

Yasutomo Nasu
Terry L. Timme
Timothy C. Thompson
Research01 Sept 1998
Nature Medicine

Volume: 4, P: 1062-1064
Borg proteins control septin organization and are negatively regulated by Cdc42

Gérard Joberty
Richard R. Perlungher
Ian G. Macara
Research31 Aug 2001
Nature Cell Biology

Volume: 3, P: 861-866
Modeling formalin fixation and antigen retrieval with bovine pancreatic RNase A II. Interrelationship of cross-linking, immunoreactivity, and heat treatment

Vladimir K Rait
Lixin Xu
Jeffrey T Mason
Research26 Jan 2004
Laboratory Investigation

Volume: 84, P: 300-306

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