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A transcriptome atlas of Xenopus tropicalis reveals the role of the immune-reproductive trade-off mediated by metabolic reprogramming in maintaining homeostasis from the perspective of inter-organ crosstalk.

Placement of an m⁷G cap internally on circular RNAs promotes their translation in vivo.

Here, the authors identify a copy number variation containing three enhancers (PIHEC) that drives bilateral constricted ear by co-ordinately regulating HMX1 expression, revealing how aberrant Hmx1 expression in neural crest-derived fibroblasts disrupts outer ear development.

Mechanical degradation is an undesired behaviour for battery electrode materials such as lithiated silicon. Here, the authors performin situnanomechanical experiments and atomistic modelling to reveal the damage tolerance of electrochemically lithiated silicon.

Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by rapid motor neuron (MN) degeneration, with unclear causes in sporadic cases. Here, the authors showed that N6-methyladenosine (m6A) RNA modification drives ALS, and restoring it may protect MNs and lessen motor issues.

C–C bond cleavage and recombination provide an efficient strategy for the modification and reconstruction of molecular structures. Herein, the authors report a method to achieve amidation of aryl C(sp2)–H bonds by cleavage and recombination of C–C triple bonds with the participation of nitrous acid esters.

Here the authors apply long read sequencing to identify transcripts expressed during early zebrafish embryogenesis, including transposable elements (TE). They find zygotic TE activation occurs later than zygotic genome activation (ZGA) and has a bias for nuclear localized TE transcripts.

The behavior of lithium metal batteries at various gravity levels is not yet clearly understood. Here, the authors demonstrate the beneficial effect of supergravity in terms of battery performance improvement and favorable solid electrolyte interphase formation.

PAPD5 is responsible for adenylation of microRNAs. Here, the authors show that elevated level of PAPD5 enhances the adenylation and reduced expression of miR-7-5p. As a result, expression of TAB2, a target of miR-7-5p, is induced triggering neuronal apoptosis in Huntington’s disease.

Dendritic cells play pivotal roles in the immune response to viral infection but are targeted by flaviviruses resulting in evasion of the host response. Here the authors show Zika but not Dengue virus limits the NF-κB response in monocyte derived dendritic cells diminishing their ability to activate T cells.

Graphene is widely used as an electrode material but the understanding of its interface with electrolyte remains elusive. Here, authors employ gap-enhanced Raman spectroscopy and find that the charging mechanism shifts from co-ion desorption to ion exchange as the number of graphene layers increase.

Undefined vacuole-like ultrastructures between epididymal cells have been observed. Here, the authors reveal that these structures contain organelle residues and protein aggregates that suggest a reservoir for protein recycling.

Oxide solid electrolytes generally suffer from high grain boundary resistance. Here, the authors use advanced electron microscopy, along with an active learning moment tensor potential, to reveal the atomic-scale origin of low grain-boundary resistance in Li_0.375Sr_0.4375Ta_0.75Zr_0.25O₃.

Chemical water treatment through heterogeneous advanced oxidation offers promise for decentralized applications. Here, authors challenge the conventional electron-transfer mechanism of O–O activation, demonstrating that at solid-water interfaces, the process involves coupled proton-electron transfer rather than pure electron transport.

Li et al. demonstrate the critical role of skeletal muscle stem cells (MuSCs) in actively shaping their niche in dystrophic muscle through YY1-CCL5-CCR5 axis mediated cellular interaction with macrophages.

A quantum microsatellite, with a payload weighing only 23 kilograms, in combination with portable ground stations that weigh merely 100 kilograms, is capable of performing space-to-ground real-time quantum key distribution.

This study details a process of duplicated (homoeologous) chromosome ‘scrambling’ in newly formed rice polyploids, indicating the possibility of natural ‘allo-to-autopolyploid’ evolution, with implications for polyploid crop breeding.

Gestational diabetes milletus (GDM) may have impairments on offspring health. Here, the authors suggest that the increase of EZH2 is an important reason for the disrupted DNA methylome in oocytes exposed to GDM, which may be associated with the transgenerational inheritance of the metabolic disorders.

An optimized Co–Ni alloy catalyst encapsulated with Sm₂O₃-doped CeO₂ shows both high activity and stability for high-temperature CO₂-to-CO conversion, overcoming the limitations of such catalysts typically used in industrial applications.

Interferon-γ (IFNγ)-activated calcium/calmodulin-dependent protein kinase II (CAMK2) phosphorylates phosphoserine aminotransferase 1 (PSAT1) at serine 337 (S337), enabling glutathione peroxidase 4 (GPX4) interaction, promoting α-ketoglutarate-dependent PHD3-mediated GPX4 proline 159 (P159) hydroxylation and stabilizing GPX4 to counteract ferroptosis.

High ionic conductivity in solid electrolytes is dependent on the existence of features that interrupt the periodic nature of host materials. Here, the authors enrich the defect chemistry in a typical Li-ion conductor, reporting atom-thick planar defects that form closed loops and trap mobile species.

Swanton and colleagues present a clonal expression signature, ORACLE, which, in combination with clinicopathological and molecular risk factors, can predict survival of patients with lung adenocarcinoma, and they prospectively validate its prognostic value.

Electrochemical-mechanical issues bring challenges but create new opportunities to design innovative all-solid-state batteries. Here, the authors propose to use the (de)lithiation-stress-creep synergistic time-dependent evolution to boost the electrochemical performance of all-solid-state batteries.

The role of KLF10 in exercise-mediated anti-obesity effects is not clear. Here, the authors show that exercise-induced adipose KLF10 interacts with FOXO1 and recruits KDM4A to transactivate lipolytic genes, which defends against obesity in male mice.

Experimentally probing the orbital population is highly desirable to resolve the redox mechanism of cathodes materials. Here the authors quantify the orbital populations of Co and O in LiCoO₂ and identify the ligand-to-metal charge transfer.

The conserved GTPase OLA1 participates in translation. Here, authors demonstrate its role in alleviating translation stalling on D/E-rich mRNA, providing mechanistic insights into OLA1’s function in stress response and tumor progression.

Sodium layered metal oxides suffer from irreversible structural deterioration at high voltage in sodium-ion batteries. Here, authors develop a magnesium ion and vacancy dual-doping strategy to enhance the anionic redox reversibility and structural stability of layered oxides.

Active chlorine is the most widely used water disinfectant, but its production has environmental consequences. This work shows a photoelectrochemical synthetic route using only solar energy and seawater.

A connectome of the right optic lobe from a male fruitfly is presented together with an extensive collection of genetic drivers matched to a comprehensive neuron-type catalogue.

Hemostatic failure and the risk of rebleeding present significant challenges. Here, Chen et al. design a covalently reactive hemostat based on blood-imbibing and -crosslinking microparticles, achieving rapid hemostasis and preventing rebleeding.

Matrix stiffness induced nuclear deformation regulates gene expression. This study finds that cell spreading on a stiff matrix induces tension in the nuclear lamina which promotes nuclear localization of yes associated protein (YAP), a transcriptional co-activator.

Water adsorbed on the electrode surface of electrochemical energy storage devices narrows the electrochemical windows. Combining atomistic simulations and cyclic voltammetry experiments the authors demonstrate an approach to expand the voltage window of humid ionic liquids based on the addition of lithium salt.