Nature Search

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

Nancy A. Thornberry
Herbert G. Bull
Michael J. Tocci
Research30 Apr 1992
Nature

Volume: 356, P: 768-774
PML-RAR&x03B1; enhances autophagic activity through inhibiting Akt/mTOR pathway

Guo-Qiang Chen
Ying Huang
Scott Kogan
ResearchOpen Access15 Nov 2010
Nature Precedings

P: 1
Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease

Chou et al. generate transdifferentiated human neurons from fibroblasts from young or aged individuals and patients with Alzheimer’s disease. Studies of endolysosomes and proteostasis suggest a role for lysosomal quality control in Alzheimer’s disease pathology.

Ching-Chieh Chou
Ryan Vest
Judith Frydman
ResearchOpen Access26 Mar 2025
Nature Cell Biology

Volume: 27, P: 619-632
In situ analysis reveals the TRiC duty cycle and PDCD5 as an open-state cofactor

TRiC functions at near full occupancy to fold newly synthesized proteins inside cells.

Huaipeng Xing
Remus R. E. Rosenkranz
Martin Beck
ResearchOpen Access11 Dec 2024
Nature

Volume: 637, P: 983-990
Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy

Huang et al. show that ADAM9 loss upregulates PAI-1, promoting its interaction with KRAS and resulting in selective lysosomal degradation of KRAS. They also identify a small-molecule inhibitor of ADAM9 with therapeutic benefits in the context of PDAC.

Yu-Kai Huang
Wei-Chung Cheng
Yuh-Pyng Sher
Research24 Jan 2024
Nature Cancer

Volume: 5, P: 400-419
Altered assembly paths mitigate interference among paralogous complexes

Understanding assembly processes of protein complexes is crucial. The authors have developed a method to deduce protein complex assembly paths in living cells, revealing that the altered assembly pathways of paralogous complexes enable neo-functionalization and mitigate cross-complex interference.

Chi-Wei Yeh
Kuan-Lun Hsu
Hsueh-Chi S. Yen
ResearchOpen Access21 Aug 2024
Nature Communications

Volume: 15, P: 1-18
Polyglutamine-mediated ribotoxicity disrupts proteostasis and stress responses in Huntington’s disease

Aviner et al. show that translation and aggregation of Huntingtin (HTT) are regulated by a stress-responsive upstream open reading frame. Mutant HTT depletes translation elongation factor eIF5A, leading to ribosome pausing and collisions.

Ranen Aviner
Ting-Ting Lee
Judith Frydman
Research13 May 2024
Nature Cell Biology

Volume: 26, P: 892-902
LMO7 deficiency reveals the significance of the cuticular plate for hearing function

In contrast to the extensively studied mechanosensory hair bundle, the cuticular plate is not as well understood. In this study, authors describe the discovery of a hair cell protein called LIM only protein 7, which is localized in the cuticular plate and the cell junction and may play a role in age-related deafness.

Ting-Ting Du
James B. Dewey
Jung-Bum Shin
ResearchOpen Access08 Mar 2019
Nature Communications

Volume: 10, P: 1-15
Association of alpha-fetoprotein and metastasis for small hepatocellular carcinoma: A propensity-matched analysis

Yu-Qi Wang
An-Jiang Wang
Si-Hai Chen
ResearchOpen Access20 Sept 2022
Scientific Reports

Volume: 12, P: 1-9
Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

Edwina C Lerner
Ting-Ting Zhang
Saïd M Sebti
Research11 Sept 1997
Oncogene

Volume: 15, P: 1283-1288
p53 induced by ionizing radiation mediates DNA end-jointing activity, but not apoptosis of thryroid cells

Ting-ting Yang
Hiroyuki Namba
Shunichi Yamashita
Research03 Apr 1997
Oncogene

Volume: 14, P: 1511-1519
Adult NTRK-rearranged spindle cell neoplasms of the viscera: with an emphasis on rare locations and heterologous elements

Jen-Wei Tsai
Jen-Chieh Lee
Hsuan-Ying Huang
Research11 Feb 2022
Modern Pathology

Volume: 35, P: 911-921
Motivational system modulates brain responses during exploratory decision-making

Chia-Wei Li
Carol Yeh-Yun Lin
Danchi Tan
ResearchOpen Access04 Aug 2021
Scientific Reports

Volume: 11, P: 1-12
53BP1 contributes to regulation of autophagic clearance of mitochondria

Cha Kyung Youn
Hong Beum Kim
Jung-Hee Lee
ResearchOpen Access27 Mar 2017
Scientific Reports

Volume: 7, P: 1-11
Impacts of stroke and cognitive impairment on activities of daily living in the Taiwan longitudinal study on aging

Pi-Hsia Lee
Ting-Ting Yeh
Shu-Chun Lee
ResearchOpen Access09 Jun 2021
Scientific Reports

Volume: 11, P: 1-9
CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-κB pathways

In-Yu Lin
Min-Hsiung Pan
Nianhan Ma
ResearchOpen Access07 Jul 2017
Scientific Reports

Volume: 7, P: 1-13
CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life

Sailaja Elchuri
Terry D Oberley
Ting-Ting Huang
Research08 Nov 2004
Oncogene

Volume: 24, P: 367-380
Dosimetric and radiobiological comparison of treatment plan between CyberKnife and EDGE in stereotactic body radiotherapy for pancreatic cancer

Zhi-tao Dai
Li Ma
Ning Li
ResearchOpen Access18 Feb 2021
Scientific Reports

Volume: 11, P: 1-11
The hippocampal extracellular matrix regulates pain and memory after injury

Maral Tajerian
Victor Hung
J. David Clark
ResearchOpen Access26 Sept 2018
Molecular Psychiatry

Volume: 23, P: 2302-2313

Search

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

PML-RAR&x03B1; enhances autophagic activity through inhibiting Akt/mTOR pathway

Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease

In situ analysis reveals the TRiC duty cycle and PDCD5 as an open-state cofactor

Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy

Altered assembly paths mitigate interference among paralogous complexes

Polyglutamine-mediated ribotoxicity disrupts proteostasis and stress responses in Huntington’s disease

LMO7 deficiency reveals the significance of the cuticular plate for hearing function

Association of alpha-fetoprotein and metastasis for small hepatocellular carcinoma: A propensity-matched analysis

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

p53 induced by ionizing radiation mediates DNA end-jointing activity, but not apoptosis of thryroid cells

Adult NTRK-rearranged spindle cell neoplasms of the viscera: with an emphasis on rare locations and heterologous elements

Motivational system modulates brain responses during exploratory decision-making

53BP1 contributes to regulation of autophagic clearance of mitochondria

Impacts of stroke and cognitive impairment on activities of daily living in the Taiwan longitudinal study on aging

CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-κB pathways

CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life

Dosimetric and radiobiological comparison of treatment plan between CyberKnife and EDGE in stereotactic body radiotherapy for pancreatic cancer

The hippocampal extracellular matrix regulates pain and memory after injury

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