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Exciton-polaritons are hybrid light matter quasi-particles, which can occur in systems exhibiting strong light-matter coupling. Here, Wang et al study exciton-polaritons in the van der Waals antiferromagnetic material, CrSBr, coupled to a Tamm plasmon microcavity and find the exciton-polaritons are sensitive to and can be tuned by the magnetic order of CrSBr.

Natural antimicrobial metabolites produced by soil microorganisms can be used as green pesticides. Here, the authors isolated a Pseudomonas mosselii strain 923 from rice rhizosphere soils and identify the compound pyrazolotriazine pseudoiodinine inhibits the growth of plant bacterial and fungal pathogens.

Carbon materials prepared by high-temperature pyrolysis generally come with amorphous structure tethering performance improvement. Here, authors create crystalline nanocarbon with both high stacking order and doping level of heteroatoms, which finds high efficiency in Fenton-like reaction for water purification.

Pityriasis rubra pilaris (PRP) is a chronic immune‐mediated papulosquamous dermatosis and is caused by dysregulation of keratinocytes. Here the authors identify keratin 32 (KRT32) mutations associated with PRP which results in the inhibitory function of KRT32 towards NF-kB signalling and IKK complex formation being reduced.

Wang et al. discovered that many cancer-causing fusion proteins form abnormal condensates that affect gene expression and developed a kinetics-dependent screening method called DropScan to find drugs that can dissolve the abnormal condensates to restore normal gene expression.

In this work, the authors report Cryo-EM structures of the signaling complexes of human GPR21, an orphan GPCR and a potential metabolic disease target, and reveal unique receptor activation conformation when bound to downstream signaling proteins in the absence of any ligand.

Hybrids can be self-pollinated to produce true-breeding progeny through seeds by simultaneous genome editing of four endogenous genes in a rice F₁ hybrid variety.

Myelodyplastic hematopoietic stem cells (MDS HSC) have eluded in vivo modeling. Here the authors present a highly efficient MDS patient-derived xenotransplantation model in cytokine-humanized mice with replication of the donors’ genetic complexity and myeloid, erythroid, and megakaryocytic lineage dysplasia.

While water splitting in acid offers higher operational performances than in alkaline conditions, there are few high-activity, acid-stable oxygen evolution electrocatalysts. Here, authors examine electrochemical Li intercalation to improve the activity and stability of RuO₂ for acidic water oxidation.

Here the authors have developed a superconducting microwave frequency comb that is fully integrated, easy to manufacture, and operates with ultra-low power consumption, and could significantly advance microwave photonics and quantum processor integration.

A comprehensive time series characterization of a mouse model of cholestatic liver injury with spatial enhanced resolution omics sequencing and single-cell RNA sequencing identifies zonal responses to insult, such as cholangiocyte signaling recruiting lipid-associated macrophages.

Comparing to other biological systems, our understanding of plant extrachromosomal circular DNA (eccDNA) is limited. Here, the authors profile eccDNA from six rice tissues and investigate eccDNA characteristics, formation mechanisms, distribution, and functional implications.

Recent advances in artificial intelligence require massive resources, and optical computing is emerging as a fast and energy-efficient alternative for AI tasks. In this work, the authors develop an optoelectronic generative adversarial network that combines optical and electronic components to achieve fast, energy-efficient image generation.

Developing non-noble-metal heterogeneous catalysts with high efficiency in HCOOH dehydrogenation is significant for the acquisition of hydrogen, but remains a great challenge. Here, the authors modulate oxygen coverage of Ti₃C₂T_x MXenes to boost the catalytic activity toward HCOOH dehydrogenation.

Here, the authors characterise an aldo-keto reductase AKRtyl, which belongs to a previously unidentified subfamily AKR12D. They uncover a complex mechanism of allosteric regulation that is mediated by 3 distinct states.

Migrasomes are recently discovered extracellular vesicles that are produced during cellular migration. Here, the authors show that macrophage-derived migrasomes are implicated in the progression of cerebral amyloid angiopathy (CAA) through increased complement signaling using skin biopsies from CAA patients and CAA mouse models.

Organ regeneration by transplantation of ESC/iPSC-derived tissues is a promising but still challenging approach. Here Lin et al. show that liver damage caused by a chemical insult induces not only fibrosis but also Lgr5⁺ cell expansion that can be further promoted by treatment with HGF/R-spondin1.

The catalytic partial oxidation of methane (POM) is a promising technology for synthesizing syngas but suffers from severe over-oxidation on the catalyst surface. Here the authors demonstrate that regulating O* occupation in an atomically dispersed MoNi alloy can achieve high catalytic performance for POM.

Follicular helper T cells (T_FH cells) require the transcription factor Bcl-6 and are antagonized by the transcription factor Blimp1 (encoded by Prdm1). Lilin Ye and colleagues show that acute viral infection induces the transcription factor TCF-1, which promotes T_FH differentiation by enhancing Bcl6 expression while suppressing that of Prdm1.

Pseudorabies virus (PRV) is a major etiological agent of swine infectious diseases responsible for significant economic losses in the swine industry. The authors report the structures of the PRV A-capsid and C-capsid, shedding light on PRV’s assembly mechanism.

Lithium-rich layered oxides are promising cathode materials for next-generation batteries, but they suffer from long-standing problems such as voltage decay during cycling. Here the authors analyse the root cause of voltage decay and present a structure engineering strategy to mitigate the issue for a cobalt-free, lithium-rich layered oxide.

The UBXN proteins are likely involved in a diverse range of biological processes, but their physiological functions remain largely unknown. Here the authors show that UBXN3B positively regulates STING-mediated immune responses in the context of viral infections.

Bin Han and colleagues report the draft genome sequence of the grass carp Ctenopharyngodon idellus, a major commercially farmed species of freshwater fish. Analyses of the grass carp genome identify lineage-specific duplications that may have contributed to the adaptation of this species to a vegetarian diet.

Two-dimensional Ruddlesden–Popper layered metal-halide perovskites show better performance over three-dimensional versions, but are typically based on quantum wells with random width distribution. Liang et al. show that introducing molten salt spacers gives phase-pure quantum wells and improved solar cell performance.

Serine/threonine kinases (STKs) regulate the synthesis of capsular polysaccharide in bacteria through unclear mechanisms. Here, Tang et al. identify a protein that is phosphorylated by an STK and modulates the activity of a phosphoregulatory system in Streptococcus suis, thus linking STKs to capsular polysaccharide synthesis.

Kang et al. reveal that GAB, classically known as a neurotransmitter, can control pro-inflammatory T_H17 cell and anti-inflammatory iT_reg cell differentiation in a cell-autonomous manner, thus modulating T cell-mediated inflammation.

Genome-wide profiling of chromatin accessibility by DNase-seq or ATAC-seq has been widely used to identify regulatory DNA elements and transcription factor binding sites. Here the authors develop a computational model, SELMA, to estimate and correct enzymatic cleavage biases in chromatin accessibility profiling data.

TREM2 is a genetic risk factor for Alzheimer’s disease, and soluble TREM2 (sTREM2) in the CSF correlates with AD progression. Here the authors study the role of sTREM2 in a mouse model of Alzheimer’s disease, and find it reduces amyloid accumulation and increases the numbers of plaque-associated microglia which correlates with improved behavioural function in the mice.

The neural circuits through which the substantia nigra pars reticulata (SNr) exerts its role in epilepsy control are not known. Here the authors reveal that a long-range SNr-parafascicular nucleus disinhibitory circuit participates in regulating seizures in temporal lobe epilepsy and inhibition of this circuit can alleviate severity of epileptic seizures.

Polo-like kinase 1 (Plk1) is a key regulator of mitosis. Here, the authors show that Plk1 activates the pentose phosphate pathway in cancer cells by directly phosphorylating glucose-6-phosphate dehydrogenase (G6PD) and that such activation is critical for cell cycle progression and cancer cell growth.

Changes in DNA methylation during mammalian spermatogenesis are poorly understood. The authors show that the content of 5-hydroxymethylcytosine, a stable intermediate of DNA demethylation, changes dynamically during mouse spermatogenesis and is associated with functional genomic regions and transcription.

How the two types of key trans-acting factors, PLS-type pentatricopeptide repeat protein and the multiple organellar RNA editing factor, cooperate in plant RNA editing remains unknown. A study now uses crystal structures to characterize the mechanism.

Bin Han and colleagues performed low-coverage sequencing of 517 rice landraces and constructed a high-density haplotype map of the rice genome. They have used this resource to carry out genome-wide association studies for 14 agronomic traits and identify 80 loci with strong association signals.

Multi-omics profiling of matched normal colon, primary tumor, and liver metastasis from colorectal carcinoma patients based on Hi-C, ATAC-seq and RNA-seq technologies sheds light on the changes and regulatory mechanisms of 3D genomics during the tumorigenesis and metastasis of colorectal carcinoma.