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Showing 1–12 of 12 results
Advanced filters: Author: Tobias Janowitz Clear advanced filters

  • The tumor microenvironment is composed of many cell types that crosstalk to modulate local immunity. Here the authors show that Amyloid β proteins from cancer-associated fibroblasts (CAF) induce neutrophil extracellular trap (NET) production by neutrophils, while NET feeds back to activate CAF, thereby implicating Amyloid β as a potential therapy target.

    • Hafsa Munir
    • James O. Jones
    • Jacqueline D. Shields
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Elevation of IL-6 during cancer progression has been shown to drive cancer cachexia, however, while brain dysfunction has been reported, the underlying mechanism is unclear. Here, the authors identify neurons in the area postrema as a mediator of peripheral IL-6 in preclinical models of cancer cachexia.

    • Qingtao Sun
    • Daniëlle van de Lisdonk
    • Bo Li
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • In this Roadmap, Boire et al. consider the immediate causes of mortality in patients with cancer, a topic not often considered in either preclinical or clinical research, and provide recommendations for how we can stimulate research to advance our mechanistic understanding of these causes with a long-term view to improving the quality of life for patients with late-stage cancer.

    • Adrienne Boire
    • Katy Burke
    • Erik Sahai
    Reviews
    Nature Reviews Cancer
    Volume: 24, P: 578-589

  • An unprecedented number of potentially disruptive therapeutic technologies are under development. Forward-looking policies, incentives and infrastructure are needed to harness these advances to provide effective and globally equitable healthcare.

    • David J. Ecker
    • Clarice D. Aiello
    • Michael R. Hayden
    Comments & Opinion
    Nature Reviews Drug Discovery
    Volume: 23, P: 321-322

  • In this Review, Erez and colleagues examine the complex interactions among tumours, their microenvironment and the host, shaping a metabolic macroenvironment that drives cancer progression. They explore how this crosstalk impacts on metastasis, inflammation and cachexia, providing insights for enhanced cancer management.

    • Patricia Altea-Manzano
    • Amanda Decker-Farrell
    • Ayelet Erez
    Reviews
    Nature Reviews Cancer
    Volume: 25, P: 274-292

  • Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.

    • Edith Hofer
    • Gennady V. Roshchupkin
    • Sudha Seshadri
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • In this Review, Dai, Stockwell, Kroemer, Tang and colleagues offer a comprehensive discussion of the molecular regulation of ferroptosis and highlight how this may be potentially leveraged for therapeutic benefit for disease treatment.

    • Enyong Dai
    • Xin Chen
    • Daolin Tang
    Reviews
    Nature Cell Biology
    Volume: 26, P: 1447-1457

  • This Consensus Statement highlights the importance of cancer-associated fibroblasts in cancer biology and progression, and issues a call to action for all cancer researchers to standardize assays and report metadata in studies of cancer-associated fibroblasts to advance our understanding of this important cell type in the tumour microenvironment.

    • Erik Sahai
    • Igor Astsaturov
    • Zena Werb
    ReviewsOpen Access
    Nature Reviews Cancer
    Volume: 20, P: 174-186