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Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS

Noncoding transcripts contribute to the adaptation of cellular processes to oxygen levels. Here the authors characterize a hypoxia responsive lncRNA lincNORS and show that it has a role in cellular sterol homeostasis.

Xue Wu
Cristina M. Niculite
Mircea Ivan
ResearchOpen Access21 Sept 2020
Nature Communications

Volume: 11, P: 1-17
SMN-primed ribosomes modulate the translation of transcripts related to spinal muscular atrophy

Lauria et al. show that SMN, the loss of which causes spinal muscular atrophy (SMA), preferentially positions ribosomes within the first five codons of SMA-related mRNAs and enhances their translation.

Fabio Lauria
Paola Bernabò
Gabriella Viero
Research21 Sept 2020
Nature Cell Biology

Volume: 22, P: 1239-1251
The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells

Alimonti and colleagues show that coordinated activation of the Akt/mTOR and MNK/eIF4E pathways rewires the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells, which can be therapeutically targeted.

Daniela Brina
Adele Ponzoni
Andrea Alimonti
Research17 Jul 2023
Nature Cancer

Volume: 4, P: 1102-1121
A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies

Myelodyplastic hematopoietic stem cells (MDS HSC) have eluded in vivo modeling. Here the authors present a highly efficient MDS patient-derived xenotransplantation model in cytokine-humanized mice with replication of the donors’ genetic complexity and myeloid, erythroid, and megakaryocytic lineage dysplasia.

Yuanbin Song
Anthony Rongvaux
Stephanie Halene
ResearchOpen Access21 Jan 2019
Nature Communications

Volume: 10, P: 1-14
A slow-cycling/quiescent cells subpopulation is involved in glioma invasiveness

Quiescent cancer stem cells have been particularly associated to chemoresistance. Here, the authors show that a slowcycling subpopulation in high-grade glioma patients can invade the brain to promote tumourigenesis.

Francesco Antonica
Lucia Santomaso
Luca Tiberi
ResearchOpen Access15 Aug 2022
Nature Communications

Volume: 13, P: 1-15
Publisher Correction: Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS

Xue Wu
Cristina M. Niculite
Mircea Ivan
Amendments and CorrectionsOpen Access06 Nov 2020
Nature Communications

Volume: 11, P: 1
eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription

Insulin enhances mRNA translation via the translation initiation factor eIF6. Here, Brina et al. show that insulin-mediated activation of eIF6 is associated with the selective translation of genes involved in glycolysis and lipid synthesis with characteristic G/C-rich and uORF sequences in their mRNA.

Daniela Brina
Annarita Miluzio
Stefano Biffo
ResearchOpen Access18 Sept 2015
Nature Communications

Volume: 6, P: 1-15
Ezrin drives adaptation of monocytes to the inflamed lung microenvironment

Ravindra Gudneppanavar
Caterina Di Pietro
Emanuela M. Bruscia
ResearchOpen Access29 Nov 2024
Cell Death & Disease

Volume: 15, P: 1-17
SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells

Yang Liang
Toma Tebaldi
Stephanie Halene
Research01 Jun 2018
Leukemia

Volume: 32, P: 2659-2671
In vivo anti-tumor effect of PARP inhibition in IDH1/2 mutant MDS/AML resistant to targeted inhibitors of mutant IDH1/2

Rana Gbyli
Yuanbin Song
Stephanie Halene
Research10 Mar 2022
Leukemia

Volume: 36, P: 1313-1323

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Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS

SMN-primed ribosomes modulate the translation of transcripts related to spinal muscular atrophy

The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells

A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies

A slow-cycling/quiescent cells subpopulation is involved in glioma invasiveness

Publisher Correction: Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS

eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription

Ezrin drives adaptation of monocytes to the inflamed lung microenvironment

SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells

In vivo anti-tumor effect of PARP inhibition in IDH1/2 mutant MDS/AML resistant to targeted inhibitors of mutant IDH1/2

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