Fukuhara et al. evaluate different methods to express IL-12 as an immunostimulatory payload of oncolytic HSV-1 using G47∆ as the backbone. They find that expressing the two IL-12 subunits as a fusion peptide leads to superior efficacy of the oncolytic virus in tumor models, compared with a virus in which the subunits have been co-expressed.
- Hiroshi Fukuhara
- Yuzuri Tsurumaki Sato
- Tomoki Todo
