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Forward-genetics analysis of sleep in randomly mutagenized mice

Two mutations affecting the sleep–wakefulness balance in mice are detected, showing that the SIK3 protein kinase is essential for determining daily wake time, and the NALCN cation channel regulates the duration of rapid eye movement sleep.

Hiromasa Funato
Chika Miyoshi
Masashi Yanagisawa
Research02 Nov 2016
Nature

Volume: 539, P: 378-383
An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension

Pulmonary arterial hypertension is a progressive fatal disease characterized by pathological pulmonary artery remodeling. Here the authors show that the dysregulation of the activin A-bone morphogenetic protein receptor type 2 link in the endothelium is involved in the progression of pulmonary hypertension.

Gusty R. T. Ryanto
Koji Ikeda
Noriaki Emoto
ResearchOpen Access19 Mar 2021
Nature Communications

Volume: 12, P: 1-14
Kinase signalling in excitatory neurons regulates sleep quantity and depth

Forward genetics analyses and targeted genetic manipulation in mice show that regulation of sleep quantity and quality is mediated by the LKB1–SIK3–HDAC4–HDAC5 pathway.

Staci J. Kim
Noriko Hotta-Hirashima
Hiromasa Funato
Research07 Dec 2022
Nature

Volume: 612, P: 512-518
Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum

GABAergic neuron progenitors in the cerebellum give rise to Purkinje cells and GABAergic interneurons. Here the authors show that the transcription factors Olig2 and Gsx1 regulate an identity transition from Purkinje cell progenitors to interneuron progenitors during mouse development.

Yusuke Seto
Tomoya Nakatani
Mikio Hoshino
Research18 Feb 2014
Nature Communications

Volume: 5, P: 1-13
Ptf1a inactivation in adult pancreatic acinar cells causes apoptosis through activation of the endoplasmic reticulum stress pathway

Morito Sakikubo
Kenichiro Furuyama
Yoshiya Kawaguchi
ResearchOpen Access25 Oct 2018
Scientific Reports

Volume: 8, P: 1-10
Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein

Tardigrades are resistant to extreme environmental conditions including dehydration, radiation and the vacuum of space. Here the authors present a high-quality genome which displays minimal horizontal gene transfer, and identify the unique tardigrade protein Dsup which suppresses DNA damage.

Takuma Hashimoto
Daiki D. Horikawa
Takekazu Kunieda
ResearchOpen Access20 Sept 2016
Nature Communications

Volume: 7, P: 1-14
Comparative analysis of chimpanzee and human Y chromosomes unveils complex evolutionary pathway

Yoko Kuroki
Atsushi Toyoda
Asao Fujiyama
Research01 Jan 2006
Nature Genetics

Volume: 38, P: 158-167
Exocyst complex component 1 (Exoc1) loss in dormant oocyte disrupts c-KIT and growth differentiation factor (GDF9) subcellular localization and causes female infertility in mice

Chi Lieu Kim Nguyen
Yumeno Kuba
Seiya Mizuno
ResearchOpen Access20 Jan 2025
Cell Death Discovery

Volume: 11, P: 1-11
Quantitative phosphoproteomic analysis of the molecular substrates of sleep need

A subset of synaptic proteins are cumulatively phosphorylated during wakefulness and dephosphorylated during sleep, in accordance with sleep need; this may represent a common mechanism underlying regulation of both synaptic homeostasis and sleep–wake homeostasis.

Zhiqiang Wang
Jing Ma
Qinghua Liu
Research13 Jun 2018
Nature

Volume: 558, P: 435-439
Genome-scale evolution in local populations of wild chimpanzees

Takashi Hayakawa
Takushi Kishida
Kiyokazu Agata
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-16
The medaka draft genome and insights into vertebrate genome evolution

The medaka fish (Oryzias latipes) has long been a popular pet in Japan and more recently a laboratory model organism; it now has its genome sequenced and analysed by a Japanese consortium.

Masahiro Kasahara
Kiyoshi Naruse
Yuji Kohara
ResearchOpen Access07 Jun 2007
Nature

Volume: 447, P: 714-719
Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need

Minjeong Park
Chika Miyoshi
Hiromasa Funato
ResearchOpen Access26 May 2020
Scientific Reports

Volume: 10, P: 1-14
Assembling the genome of the African wild rice Oryza longistaminata by exploiting synteny in closely related Oryza species

Stefan Reuscher et al. assembled the genome of an African wild rice species to facilitate breeding efforts and functional genomic studies. They used SMRT sequencing, chromosomal synteny between rice species, and a linkage map to assemble the 351 Mb genome into 12 chromosomes.

Stefan Reuscher
Tomoyuki Furuta
Motoyuki Ashikari
ResearchOpen Access05 Oct 2018
Communications Biology

Volume: 1, P: 1-10
Identification of mutations through dominant screening for obesity using C57BL/6 substrains

Mohammad Sarowar Hossain
Fuyuki Asano
Masashi Yanagisawa
ResearchOpen Access02 Sept 2016
Scientific Reports

Volume: 6, P: 1-15

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Forward-genetics analysis of sleep in randomly mutagenized mice

An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension

Kinase signalling in excitatory neurons regulates sleep quantity and depth

Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum

Ptf1a inactivation in adult pancreatic acinar cells causes apoptosis through activation of the endoplasmic reticulum stress pathway

Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein

Comparative analysis of chimpanzee and human Y chromosomes unveils complex evolutionary pathway

Exocyst complex component 1 (Exoc1) loss in dormant oocyte disrupts c-KIT and growth differentiation factor (GDF9) subcellular localization and causes female infertility in mice

Quantitative phosphoproteomic analysis of the molecular substrates of sleep need

Genome-scale evolution in local populations of wild chimpanzees

The medaka draft genome and insights into vertebrate genome evolution

Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need

Assembling the genome of the African wild rice Oryza longistaminata by exploiting synteny in closely related Oryza species

Identification of mutations through dominant screening for obesity using C57BL/6 substrains

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