Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

View all journals
Search
Log in

nature
search

Search

Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Nature Communications (5)
Nature Cell Biology (2)
Cell Death & Disease (1)

Choose more journals

Article type Check one or more article types to show results from those article types only.

Research (8)

Subject Check one or more subjects to show results from those subjects only.

Biochemistry
Cancer
Cell biology
Diseases
Molecular biology
Physiology

Date Choose a date option to show results from those dates only.

Today
Last 7 days
Last 30 days
Last 12 months
Last 2 years
Last 5 years

Custom date range

Clear all filters

Sort by:

Relevance

Date published (new to old)

Date published (old to new)

Showing 1–8 of 8 results

Advanced filters: Author: Tong-Jin Zhao Clear advanced filters

A lysosomal surveillance response to stress extends healthspan

Li et al. uncover a lysosomal surveillance response whereby intestinal lumen deacidification induces a transcriptional programme that boosts lysosomal activity and improves protein aggregate clearance in multiple worm disease models, extending healthspan.

Terytty Yang Li
Arwen W. Gao
Johan Auwerx
ResearchOpen Access26 Jun 2025
Nature Cell Biology

P: 1-15
G-protein-coupled receptor GPR17 inhibits glioma development by increasing polycomb repressive complex 1-mediated ROS production

Huiqing Liu
Rui Xing
Ying Chen
ResearchOpen Access12 Jun 2021
Cell Death & Disease

Volume: 12, P: 1-14
CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis

The mechanistic details of fatty acid uptake into cells remains poorly understood. Here, the authors identify CD36 internalization via cavaeolae and demonstrate dynamic palmitoylationof CD36 is required for endocytic uptake of fatty acids.

Jian-Wei Hao
Juan Wang
Tong-Jin Zhao
ResearchOpen Access21 Sept 2020
Nature Communications

Volume: 11, P: 1-16
Surplus fatty acid synthesis increases oxidative stress in adipocytes and induces lipodystrophy

The physiological significance of low fatty acid synthesis in adipocytes remains unclear. Here, the authors show a protective role of this phenomenon by demonstrating that overproduction of fatty acids increases ROS production and results in adipocyte necroptosis and lipodystrophy.

Li Weng
Wen-Shuai Tang
Tong-Jin Zhao
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-16
TMEM25 inhibits monomeric EGFR-mediated STAT3 activation in basal state to suppress triple-negative breast cancer progression

Aberrant EGFR expression is associated with triple-negative breast cancer (TNBC). Here the authors identify that TMEM25 interacts with EGFR and the loss of TMEM25 allows monomeric EGFR-mediated hyperactivation of STAT3 to promote TNBC progression.

Jing Bi
Zhihui Wu
Hong-Rui Wang
ResearchOpen Access24 Apr 2023
Nature Communications

Volume: 14, P: 1-15
Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system

EGFR is aberrantly activated in many cancer types. Here the authors show that small GTPase ARF6 mediates the trafficking of palmitoylated EGFR from Golgi to plasma membrane and the blockade of this sorting system inhibits the growth of EGFR overexpression tumours.

Huiling Guo
Juan Wang
Tong-Jin Zhao
ResearchOpen Access12 Oct 2022
Nature Communications

Volume: 13, P: 1-15
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1

Shi et al. show that following adrenergic signalling, PKA phosphorylates AIDA, which in turn interacts with and promotes oxidation of UCP1 to regulate UCP1-dependent adaptive thermogenesis.

Meng Shi
Xiao-Yu Huang
Sheng-Cai Lin
Research04 Mar 2021
Nature Cell Biology

Volume: 23, P: 268-277
ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage

DNA damage can lead to autophagy. Here the authors reveal a molecular mechanism for ATR/Chk1 signaling-induced autophagy in response to DNA damage, through an ATR/Chk1/RhoB-mediated lysosomal recruitment of TSC complex and subsequent mTORC1 inhibition.

Mingdong Liu
Taoling Zeng
Hong-Rui Wang
ResearchOpen Access08 Oct 2018
Nature Communications

Volume: 9, P: 1-14