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The twin-arginine translocation (Tat) protein export pathway

The twin-arginine translocation (Tat) protein export system is present in the membranes of most bacteria and archaea and transports folded proteins while maintaining the permeability barrier of the membrane. Here, Palmer and Berks summarize the recent advances in our understanding of how this remarkable system functions.

Tracy Palmer
Ben C. Berks
Reviews11 Jun 2012
Nature Reviews Microbiology

Volume: 10, P: 483-496
Structure of the TatC core of the twin-arginine protein transport system

The twin-arginine translocation (Tat) pathway transports folded proteins across membranes in bacteria and plant chloroplasts; the crystal structure of TatC, an integral membrane protein and core component of this complex, is now presented.

Sarah E. Rollauer
Michael J. Tarry
Susan M. Lea
Research02 Dec 2012
Nature

Volume: 492, P: 210-214
Global disparities in SARS-CoV-2 genomic surveillance

In this study, the authors provide a global overview of SARS-CoV-2 genome sequencing, and estimate the proportion of cases sequenced and time to genome upload. They identify disparities and highlight the need to strengthen surveillance in lower and middle income countries.

Anderson F. Brito
Elizaveta Semenova
Nuno R. Faria
ResearchOpen Access16 Nov 2022
Nature Communications

Volume: 13, P: 1-13
Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs

Human immunodeficiency virus patients who maintain low levels of virus or have undetectable levels of virus exist. In this study, the HIV found in two of these patients is shown to replicatein vitro, suggesting that host factors have a role in suppressing virus levels.

Robert W. Buckheit III
Tracy G. Allen
Joel N. Blankson
Research06 Mar 2012
Nature Communications

Volume: 3, P: 1-10
A type VII-secreted lipase toxin with reverse ___domain arrangement

Here Garrett et al. describe a toxin, TslA, secreted by type VII secretion system that has a reverse ___domain arrangement compared to other previously characterised substrates. The authors show that TslA is a lipase with antibacterial activity.

Stephen R. Garrett
Nicole Mietrach
Tracy Palmer
ResearchOpen Access19 Dec 2023
Nature Communications

Volume: 14, P: 1-16
Non-human primate model of long-COVID identifies immune associates of hyperglycemia

After infection with SARS-CoV-2 a diverse set of symptoms remain or develop longer term in a condition termed long-CoVID, yet an accurate and tractable model has remained elusive. Here the authors present a non-human primate model of long-CoVID and show persistent hyperglycemia following acute infection.

Clovis S. Palmer
Chrysostomos Perdios
Jay Rappaport
ResearchOpen Access20 Aug 2024
Nature Communications

Volume: 15, P: 1-18
Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis

While antibodies neutralize HIV via Fab recognition of viral surface antigens, antibody Fc domains mediate effector functions, including antibody-dependent cellular phagocytosis (ADCP) and cytotoxicity (ADCC), and complement (C') activity. Here, Spencer et al. modify bNAb 10E8v4 to enhance C'-mediated potency in SHIV challenged rhesus macaques to probe its function in protection, showing that in the absence of neutralization, enhancing C' activities in vitro adds no value toward reducing viremia in either blood or tissue.

David A. Spencer
Benjamin S. Goldberg
Ann J. Hessell
ResearchOpen Access03 Feb 2022
Nature Communications

Volume: 13, P: 1-14
e-Science: relieving bottlenecks in large-scale genome analyses

Affordable, high-throughput sequencing technology has led to a flood of publicly available bacterial genome sequence data, presenting both an opportunity and a challenge for the microbiologist. New computational approaches, such as e-Science and Grid-based technologies, can help to analyse genomic data and address these challenges.

Tracy Craddock
Colin R. Harwood
Anil Wipat
Reviews01 Dec 2008
Nature Reviews Microbiology

Volume: 6, P: 948-954
SuPAR mediates viral response proteinuria by rapidly changing podocyte function

Proteinuric kidney diseases are on the rise and have limited treatment options. Here, the authors show soluble urokinase receptor (suPAR) orchestrates viral response proteinuria (VRP) which occurs in response to certain viral infections and podocyte integrin engagement.

Changli Wei
Prasun K. Datta
Jochen Reiser
ResearchOpen Access21 Jul 2023
Nature Communications

Volume: 14, P: 1-12
Temperature triggers immune evasion by Neisseria meningitidis

Three Neisseria meningitidis RNA thermosensors important for resistance against complement-mediated immune killing are identified, located in the 5′ untranslated regions of genes necessary for capsule biosynthesis, expression of factor H binding protein and sialyation of lipolysaccharide; increased temperature may act as a warning signal for the bacterium, prompting it to enhance mechanisms of immune evasion.

Edmund Loh
Elisabeth Kugelberg
Christoph M. Tang
Research25 Sept 2013
Nature

Volume: 502, P: 237-240
Peak SIV replication in resting memory CD4⁺ T cells depletes gut lamina propria CD4⁺ T cells

Qingsheng Li
Lijie Duan
Ashley T. Haase
Research27 Mar 2005
Nature

Volume: 434, P: 1148-1152
Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques

Hessell et al. report that post-exposure treatment with HIV-1–specific neutralizing antibodies clears SHIV infection from the blood and tissues of infant rhesus macaques.

Ann J Hessell
J Pablo Jaworski
Nancy L Haigwood
Research21 Mar 2016
Nature Medicine

Volume: 22, P: 362-368
Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro

Bone marrow formed in a cylindrical PDMS device implanted in a mouse can be surgically removed and cultured for a week in vitro without losing any of the hallmarks of in vivo bone marrow niches.

Yu-suke Torisawa
Catherine S Spina
Donald E Ingber
Research04 May 2014
Nature Methods

Volume: 11, P: 663-669
Expressing exogenous genes in newts by transgenesis

Martin Miguel Casco-Robles
Shouta Yamada
Chikafumi Chiba
Protocols14 Apr 2011
Nature Protocols

Volume: 6, P: 600-608
Cosmid based mutagenesis causes genetic instability in Streptomyces coelicolor, as shown by targeting of the lipoprotein signal peptidase gene

John T. Munnoch
David A. Widdick
Matthew I. Hutchings
ResearchOpen Access12 Jul 2016
Scientific Reports

Volume: 6, P: 1-10
Molecular analysis of the mature T cell proliferation-1 (MTCP-1) gene in Xq28-linked incontinentia pigmenti

Hayley Woffendin
Teresa Esposito
Sue Kenwrick
Correspondence15 Jun 2000
European Journal of Human Genetics

Volume: 8, P: 239-240

Search

The twin-arginine translocation (Tat) protein export pathway

Structure of the TatC core of the twin-arginine protein transport system

Global disparities in SARS-CoV-2 genomic surveillance

Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs

A type VII-secreted lipase toxin with reverse ___domain arrangement

Non-human primate model of long-COVID identifies immune associates of hyperglycemia

Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis

e-Science: relieving bottlenecks in large-scale genome analyses

SuPAR mediates viral response proteinuria by rapidly changing podocyte function

Temperature triggers immune evasion by Neisseria meningitidis

Peak SIV replication in resting memory CD4⁺ T cells depletes gut lamina propria CD4⁺ T cells

Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques

Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro

Expressing exogenous genes in newts by transgenesis

Cosmid based mutagenesis causes genetic instability in Streptomyces coelicolor, as shown by targeting of the lipoprotein signal peptidase gene

Molecular analysis of the mature T cell proliferation-1 (MTCP-1) gene in Xq28-linked incontinentia pigmenti

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