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Showing 1–3 of 3 results
Advanced filters: Author: Trinh-Don Nguyen Clear advanced filters

  • Camptothecin derivatives are precursors of potent anticancer agents, but their biosynthesis remains largely unknown. Here two cytochrome P450 monooxygenases are shown to regiospecifically oxidize camptothecin, yielding 10- and 11- hydroxylated derivatives, which are subsequently used to produce a suite of known anticancer drugs and derivatives.

    • Tuan-Anh M. Nguyen
    • Trinh-Don Nguyen
    • Thu-Thuy T. Dang
    ResearchOpen Access
    Communications Chemistry
    Volume: 4, P: 1-7

  • The discovery of long-existing terpenoid biosynthetic pathways in soft corals changes the way specialized metabolism in animals is thought about, and opens unprecedented access to the largely untapped treasure trove of medicinal marine natural products.

    • Trinh-Don Nguyen
    • Thu-Thuy T. Dang
    News & Views
    Nature Chemical Biology
    Volume: 18, P: 582-583

  • Re-channeling metabolic routes in Nicotiana benthamiana allows elucidation and reconstitution of the biosynthesis of the natural products momilactones A and B. Insights into how plants make these and other natural crop protection chemicals promise future biotechnologies for sustainable agriculture.

    • Trinh-Don Nguyen
    • Thu-Thuy T. Dang
    News & Views
    Nature Chemical Biology
    Volume: 17, P: 126-128