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Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease

Yin et al. identify miR-155–IFN-γ signaling that regulates a protective microglial subset in a mouse model of Alzheimer’s disease. These microglia enhance plaque compaction, reduce dystrophic neurites and synaptic degradation, and improve cognition.

Zhuoran Yin
Shawn Herron
Oleg Butovsky
Research08 Jun 2023
Nature Neuroscience

Volume: 26, P: 1196-1207
Development and characterization of in vitro inducible immortalization of a murine microglia cell line for high throughput studies

Hana Yeh
Matthew A. De Cruz
Tsuneya Ikezu
ResearchOpen Access25 Jan 2025
Scientific Reports

Volume: 15, P: 1-15
Depletion of microglia and inhibition of exosome synthesis halt tau propagation

In this study, the authors show that microglia play an important role in the propagation of pathogenic tau protein. In addition, the authors find that spread of the tau protein occurs via exosome secretion from these microglial cells.

Hirohide Asai
Seiko Ikezu
Tsuneya Ikezu
Research05 Oct 2015
Nature Neuroscience

Volume: 18, P: 1584-1593
APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

The APOE4 allele is a major genetic risk factor for the development of late-onset Alzheimer’s disease (AD). In this manuscript, Butovsky and colleagues suggest that APOE4 impairs the microglial response in AD by inducing TGFβ-mediated checkpoints.

Zhuoran Yin
Neta Rosenzweig
Oleg Butovsky
Research25 Sept 2023
Nature Immunology

Volume: 24, P: 1839-1853
Impairment of PARK14-dependent Ca²⁺ signalling is a novel determinant of Parkinson’s disease

PLA2g6 regulates store-operated Ca²⁺ entry and is linked to Parkinson’s disease. Here, Zhou et al find faulty PLA2g6-dependent Ca²⁺signaling in idiopathic PD patients, and show that its impairment triggers autophagic dysfunction and loss of dopaminergic neurons in a new PLA2g6 ex2KO mouse model.

Qingde Zhou
Allen Yen
Victoria M. Bolotina
ResearchOpen Access12 Jan 2016
Nature Communications

Volume: 7, P: 1-14
Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

Apicco and colleagues show that reducing TIA1 inhibits tau-mediated neurodegeneration and improves survival in a mouse model of tauopathy. This rescue occurs with a transition in tau aggregation from oligomeric to fibrillar forms of tau. These findings suggest a key role for RNA binding proteins in the pathophysiology of tau.

Daniel J. Apicco
Peter E. A. Ash
Benjamin Wolozin
Research20 Nov 2017
Nature Neuroscience

Volume: 21, P: 72-80
Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities

Seiko Ikezu
Hana Yeh
Tsuneya Ikezu
ResearchOpen Access18 Feb 2020
Molecular Psychiatry

Volume: 26, P: 1808-1831
Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease

Rebecca Panitch
Junming Hu
Gyungah R. Jun
ResearchOpen Access03 Sept 2021
Molecular Psychiatry

Volume: 26, P: 6054-6064

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Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease

Development and characterization of in vitro inducible immortalization of a murine microglia cell line for high throughput studies

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

Impairment of PARK14-dependent Ca²⁺ signalling is a novel determinant of Parkinson’s disease

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities

Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease

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