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Advanced filters: Author: Usha Narayanan Clear advanced filters

  • This study has developed the first small molecule NEDD8-activating enzyme (NAE) inhibitor, which induces cancer cell death and exerts anti-tumour activity in preclinical mouse models. This work establishes NAE as an anti-cancer target and may lead to new anti-cancer therapeutics.

    • Teresa A. Soucy
    • Peter G. Smith
    • Steven P. Langston
    Research
    Nature
    Volume: 458, P: 732-736