Nature Search

Serum proteomics reveal APOE-ε4-dependent and APOE-ε4-independent protein signatures in Alzheimer’s disease

Using high-throughput proteomics in a prospective population-based study of older adults, Frick et al. identified over 300 proteins linked to incident late-onset Alzheimer’s disease, including associations dependent on or independent of APOE-ε4 status.

Elisabet A. Frick
Valur Emilsson
Vilmundur Gudnason
ResearchOpen Access21 Aug 2024
Nature Aging

Volume: 4, P: 1446-1464
Correction: Corrigendum: Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

Kristoffer Forslund
Falk Hildebrand
Oluf Pedersen
Amendments and Corrections04 May 2017
Nature

Volume: 545, P: 116
Identification of biomarkers for glycaemic deterioration in type 2 diabetes

There is an urgent need for biomarkers for type 2 diabetes progression that provide a deeper understanding of the disease process. Here, the authors identify biomarkers in three molecular classes, replicate them in other cohorts and explore top protein biomarkers in detail in functional studies.

Roderick C. Slieker
Louise A. Donnelly
Guy A. Rutter
ResearchOpen Access03 May 2023
Nature Communications

Volume: 14, P: 1-18
Coding and regulatory variants are associated with serum protein levels and disease

Finding the genetic basis of protein expression can elucidate the genetic mechanisms of disease. Here, the authors link low-frequency and common DNA sequence variants to thousands of serum proteins, finding genetic overlap between circulating proteins and a wide range of common diseases.

Valur Emilsson
Valborg Gudmundsdottir
Vilmundur Gudnason
ResearchOpen Access25 Jan 2022
Nature Communications

Volume: 13, P: 1-11
A genome-wide association study of serum proteins reveals shared loci with common diseases

Circulating proteins have been linked to many conditions, and understanding their genetic control can lead to understanding of disease. Here, the authors associate common genetic variants with protein levels, finding overlap of genetic associations with circulating proteins and complex disease.

Alexander Gudjonsson
Valborg Gudmundsdottir
Vilmundur Gudnason
ResearchOpen Access25 Jan 2022
Nature Communications

Volume: 13, P: 1-13
Human gut microbes impact host serum metabolome and insulin sensitivity

Increased potential for branched-chain amino acid and lipopolysaccharide biosynthesis in the gut microbiome of insulin-resistant individuals suggests that changes in the serum metabolome induced by dysbiosis, and driven by only a handful of species, contribute to the development of diabetes.

Helle Krogh Pedersen
Valborg Gudmundsdottir
Oluf Pedersen
Research13 Jul 2016
Nature

Volume: 535, P: 376-381
Author Correction: Serum proteomics reveal APOE-ε4-dependent and APOE-ε4-independent protein signatures in Alzheimer’s disease

Elisabet A. Frick
Valur Emilsson
Vilmundur Gudnason
Amendments and CorrectionsOpen Access16 Sept 2024
Nature Aging

Volume: 4, P: 1509
Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Clinical multi-omics data are integrated and analyzed using a generative deep-learning model.

Rosa Lundbye Allesøe
Agnete Troen Lundgaard
Moustafa Abdalla
ResearchOpen Access02 Jan 2023
Nature Biotechnology

Volume: 41, P: 399-408
Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Rosa Lundbye Allesøe
Agnete Troen Lundgaard
Moustafa Abdalla
Amendments and CorrectionsOpen Access02 May 2023
Nature Biotechnology

Volume: 41, P: 1026
Metabolic and proteomic signatures of type 2 diabetes subtypes in an Arab population

Four T2D subtypes were previously identified: severe insulin deficient, severe insulin resistant, mild obesity-related, and mild age-related diabetes. Here, the authors show that these subtypes can be translated to an Arabic population and identify distinct subtype-specific metabolic and proteomic signatures.

Shaza B. Zaghlool
Anna Halama
Karsten Suhre
ResearchOpen Access19 Nov 2022
Nature Communications

Volume: 13, P: 1-17
A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations

Pavithra Nagarajan
Thomas W. Winkler
Heming Wang
Research04 Apr 2025
Molecular Psychiatry

P: 1-13
A proteogenomic signature of age-related macular degeneration in blood

Age related macular degeneration is a common cause of visual impairment in the elderly, but the etiology is not fully understood. Here, the authors use genetic data, serum proteomics, and AMD phenotypic data from a large Icelandic cohort to discover proteins altered in, causally related to AMD or signifying progression of advanced AMD.

Valur Emilsson
Elias F. Gudmundsson
Tony E. Walshe
ResearchOpen Access13 Jun 2022
Nature Communications

Volume: 13, P: 1-15
Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

Many genetic variants have been associated with human traits, but the mechanism is often unknown. Here, the authors integrate local and distal genetic associations with multi-omics datasets to provide a roadmap to understand the underlying mechanisms of GWAS variants on complex traits.

Andrew A. Brown
Juan J. Fernandez-Tajes
Ana Viñuela
ResearchOpen Access21 Aug 2023
Nature Communications

Volume: 14, P: 1-17
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

Growing evidence from metagenome-wide association studies link multiple common disorders to microbial dysbiosis but effects of drug treatment are often not accounted for; here, the authors re-analyse two previous metagenomic studies of type 2 diabetes mellitus patients together with a novel cohort to determine the effects of the widely prescribed antidiabetic drug metformin and highlight the need to distinguish the effects of a disease from the effects of treatment on the gut microbiota.

Kristoffer Forslund
Falk Hildebrand
Oluf Pedersen
Research02 Dec 2015
Nature

Volume: 528, P: 262-266
The genome of a Late Pleistocene human from a Clovis burial site in western Montana

The first individual genome from the Clovis culture is presented; the origins and genetic legacy of the people who made Clovis tools have been under debate, and evidence here suggests that the individual is more closely related to all Native American populations than to any others, refuting the hypothesis that the Clovis people arrived via European (Solutrean) migration to the Americas.

Morten Rasmussen
Sarah L. Anzick
Eske Willerslev
Research12 Feb 2014
Nature

Volume: 506, P: 225-229
A reference map of potential determinants for the human serum metabolome

The levels of 1,251 metabolites are measured in 475 phenotyped individuals, and machine-learning algorithms reveal that diet and the microbiome are the determinants with the strongest predictive power for the levels of these metabolites.

Noam Bar
Tal Korem
Eran Segal
Research11 Nov 2020
Nature

Volume: 588, P: 135-140
Identification of circulating proteins associated with general cognitive function among middle-aged and older adults

Analysis of circulating proteins across multiple cohorts identifies proteins that are associated with cognitive function and may serve as targets to understand the relationship between immunity and Alzheimer’s disease risk.

Adrienne Tin
Alison E. Fohner
Myriam Fornage
ResearchOpen Access03 Nov 2023
Communications Biology

Volume: 6, P: 1-14
A computational framework to integrate high-throughput ‘-omics’ datasets for the identification of potential mechanistic links

This computational protocol offers a framework to integrate high-dimensional -omics datasets. A three-pronged association study integrating intestinal microbiome and serum metabolome data with measures of human host physiology is used as an example.

Helle Krogh Pedersen
Sofia K. Forslund
Henrik Bjørn Nielsen
Protocols31 Oct 2018
Nature Protocols

Volume: 13, P: 2781-2800
Ranking factors involved in diabetes remission after bariatric surgery using machine-learning integrating clinical and genomic biomarkers

Helle Krogh Pedersen
Valborg Gudmundsdottir
Ramneek Gupta
ResearchOpen Access26 Oct 2016
npj Genomic Medicine

Volume: 1, P: 1-8

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Serum proteomics reveal APOE-ε4-dependent and APOE-ε4-independent protein signatures in Alzheimer’s disease

Correction: Corrigendum: Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

Identification of biomarkers for glycaemic deterioration in type 2 diabetes

Coding and regulatory variants are associated with serum protein levels and disease

A genome-wide association study of serum proteins reveals shared loci with common diseases

Human gut microbes impact host serum metabolome and insulin sensitivity

Author Correction: Serum proteomics reveal APOE-ε4-dependent and APOE-ε4-independent protein signatures in Alzheimer’s disease

Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Metabolic and proteomic signatures of type 2 diabetes subtypes in an Arab population

A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations

A proteogenomic signature of age-related macular degeneration in blood

Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

The genome of a Late Pleistocene human from a Clovis burial site in western Montana

A reference map of potential determinants for the human serum metabolome

Identification of circulating proteins associated with general cognitive function among middle-aged and older adults

A computational framework to integrate high-throughput ‘-omics’ datasets for the identification of potential mechanistic links

Ranking factors involved in diabetes remission after bariatric surgery using machine-learning integrating clinical and genomic biomarkers

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