Nature Search

Increased neutralization and IgG epitope identification after MVA-MERS-S booster vaccination against Middle East respiratory syndrome

In a clinical trial, Fathi et al. show that a booster vaccination with a vector vaccine candidate against the highly pathogenic Middle East Respiratory Syndrome coronavirus is safe and strongly improves the immunity generated by primary immunization.

Anahita Fathi
Christine Dahlke
Marylyn M. Addo
ResearchOpen Access19 Jul 2022
Nature Communications

Volume: 13, P: 1-12
Author Correction: Immunogenetic-pathogen networks shrink in Tome’s spiny rat, a generalist rodent inhabiting disturbed landscapes

Ramona Fleischer
Georg Joachim Eibner
Dominik Werner Schmid
Amendments and CorrectionsOpen Access25 May 2024
Communications Biology

Volume: 7, P: 1
Immunogenicity decay and case incidence six months post Sinovac-CoronaVac vaccine in autoimmune rheumatic diseases patients

Characterising the response to SARS-CoV-2 post vaccination is critical in the appraisement of the induced immune response, performance and protective potential. Here the authors present data from a phase 4 clinical trial in autoimmune rheumatic disease patients 6 months post second dose of Sinovac-CoronaVac inactivated vaccine that show a marked reduction in antibody particularly in males or those under treatment with immune targeting therapies but saw no rise in COVID-19 disease.

Clovis A. Silva
Ana C. Medeiros-Ribeiro
Eloisa Bonfa
ResearchOpen Access03 Oct 2022
Nature Communications

Volume: 13, P: 1-9
Correction: Corrigendum: Bats host major mammalian paramyxoviruses

Jan Felix Drexler
Victor Max Corman
Christian Drosten
Amendments and Corrections23 Jan 2014
Nature Communications

Volume: 5, P: 1
Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19

Single-cell analysis reveals how anti-hypertensive drugs affect the risk of severe disease in patients with COVID-19 who have hypertension.

Saskia Trump
Soeren Lukassen
Irina Lehmann
Research24 Dec 2020
Nature Biotechnology

Volume: 39, P: 705-716
Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmission

Doreen Muth
Victor Max Corman
Christian Drosten
ResearchOpen Access11 Oct 2018
Scientific Reports

Volume: 8, P: 1-11
Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19

Radke et al. found an interferon response in the brainstem nuclei of acute COVID-19 that, in addition to the inflammatory reaction, spreads throughout the vascular unit altering glial cells and resolves in late disease states in the absence of brain infection.

Josefine Radke
Jenny Meinhardt
Helena Radbruch
Research16 Feb 2024
Nature Neuroscience

Volume: 27, P: 409-420
Pathogen-associated selection on innate immunity genes (TLR4, TLR7) in a neotropical rodent in landscapes differing in anthropogenic disturbance

Alexander Christoph Heni
Julian Schmid
Simone Sommer
ResearchOpen Access02 Jul 2020
Heredity

Volume: 125, P: 184-199
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

The authors demonstrate the presence of SARS-CoV-2 in the nasopharynx and brain, suggesting that the virus is present in the CNS and may enter through the olfactory mucosa, exploiting the close vicinity of olfactory mucosal, endothelial and nervous tissue.

Jenny Meinhardt
Josefine Radke
Frank L. Heppner
Research30 Nov 2020
Nature Neuroscience

Volume: 24, P: 168-175
SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection

Here, Gassen et al. show that S-phase kinase-associated protein 2 (SKP2) is responsible for lysine-48-linked poly-ubiquitination of beclin 1, resulting in its proteasomal degradation, and that inhibition of SKP2 enhances autophagy and reduces replication of MERS coronavirus.

Nils C. Gassen
Daniela Niemeyer
Theo Rein
ResearchOpen Access18 Dec 2019
Nature Communications

Volume: 10, P: 1-16
Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in COVID-19

Morgan Essex
Belén Millet Pascual-Leone
Bastian Opitz
ResearchOpen Access01 Aug 2024
npj Biofilms and Microbiomes

Volume: 10, P: 1-15
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals

Viruses manipulate host cell pathways to support infection. Here the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition.

Nils C. Gassen
Jan Papies
Marcel A. Müller
ResearchOpen Access21 Jun 2021
Nature Communications

Volume: 12, P: 1-15
Bats host major mammalian paramyxoviruses

The large virus family,Paramyxoviridae, includes several human and livestock viruses. This study, testing 119 bat and rodent species distributed globally, identifies novel putative paramyxovirus species, providing data with potential uses in predictions of the emergence of novel paramyxoviruses in humans and livestock.

Jan Felix Drexler
Victor Max Corman
Christian Drosten
ResearchOpen Access24 Apr 2012
Nature Communications

Volume: 3, P: 1-13
Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta

The Alpha variant of SARS-CoV-2 outcompetes progenitor SARS-CoV-2 in upper respiratory tract replication competition in vivo.

Lorenz Ulrich
Nico Joel Halwe
Charaf Benarafa
ResearchOpen Access22 Dec 2021
Nature

Volume: 602, P: 307-313
SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

A study of patients with COVID-19 and healthy donors found CD4⁺ T cells that react to the spike protein of SARS-CoV-2 and human endemic coronaviruses; however, the effect of pre-existing SARS-CoV-2 cross-reactive T cells on clinical outcomes remains to be determined.

Julian Braun
Lucie Loyal
Andreas Thiel
Research29 Jul 2020
Nature

Volume: 587, P: 270-274
SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself

Our understanding on the humoral immunity induced by SARS-CoV-2 is still lacking. Here the authors analyze B cell responses at the single cell level to find that, in severe COVID-19 patients, plasmablasts shift from IFN to TGFβ instruction to produce IgA antibodies that are not specific to dominant SARS-CoV-2 antigens.

Marta Ferreira-Gomes
Andrey Kruglov
Mir-Farzin Mashreghi
ResearchOpen Access30 Mar 2021
Nature Communications

Volume: 12, P: 1-14
Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19

Infection with SARS-CoV-2 has been linked with substantive inflammation, lung pathology and development of COVID-19. Here the authors spatially associate CCL18 and CCL21 in distinct tissue niches with lung pathology of severe COVID-19.

Ronja Mothes
Anna Pascual-Reguant
Anja E. Hauser
ResearchOpen Access11 Feb 2023
Nature Communications

Volume: 14, P: 1-16
A bead-based multiplex assay covering all coronaviruses pathogenic for humans for sensitive and specific surveillance of SARS-CoV-2 humoral immunity

Daniel Stern
Tanja C. Meyer
Brigitte G. Dorner
ResearchOpen Access09 Dec 2023
Scientific Reports

Volume: 13, P: 1-22
Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8⁺ T cells

Malte Lehmann
Kristina Allers
Britta Siegmund
ResearchOpen Access21 Aug 2021
Mucosal Immunology

Volume: 14, P: 1381-1392
Immunogenetic-pathogen networks shrink in Tome’s spiny rat, a generalist rodent inhabiting disturbed landscapes

A study on genetic diversity and multiple pathogen infections in wild rodents and reservoir hosts shows human habitat disturbance also adversely affects generalist species by limiting their adaptive potential and facilitating pathogen spill-over.

Ramona Fleischer
Georg Joachim Eibner
Dominik Werner Schmid
ResearchOpen Access10 Feb 2024
Communications Biology

Volume: 7, P: 1-11
Causes of death and comorbidities in hospitalized patients with COVID-19

Sefer Elezkurtaj
Selina Greuel
David Horst
ResearchOpen Access19 Feb 2021
Scientific Reports

Volume: 11, P: 1-9
Evidence for widespread infection of African bats with Crimean-Congo hemorrhagic fever-like viruses

Marcel A. Müller
Stéphanie Devignot
Christian Drosten
ResearchOpen Access24 May 2016
Scientific Reports

Volume: 6, P: 1-10

Search

Filter By:

Search

Quick links