Fractured long bones regenerate through osteo-angiogenic coupling, but how calvarial bone healing occurs is not yet clear. Here they show that regenerating blood vessels separate from co-migrating progenitors in calvarial bones, resulting in osteoblasts mineralizing a previously vascularized lesion.
- M. Gabriele Bixel
- Kishor K. Sivaraj
- Ralf H. Adams