Radial glia progenitors divide asymmetrically in the ventricular zone (VZ) of the developing neocortex to produce both self-renewing radial glia and differentiating cells. The latter will then leave the VZ whereas the renewing radial glia progenitors stay to divide further, but the mechanisms underlying these differences in behaviour are unclear. Asymmetric inheritance of centrosomes is now shown to regulate the differential behaviour of renewing progenitors in the embryonic mouse neocortex.
- Xiaoqun Wang
- Jin-Wu Tsai
- Song-Hai Shi
