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Here, the authors’ findings highlight genetic overlap between eating disorders, mental disorders, and cardiometabolic diseases, supporting the need for integrated treatment strategies across physical and mental health care.

Metasurfaces offer an approach for computer generated holograms with good efficiency and ease of fabrication. Here, Ye et al.report on spin and wavelength multiplexed nonlinear metasurface holography, showing construction of holographic images using fundamental and harmonic generation waves of different spins.

Infection with SARS-CoV-2 causes interstitial pneumonia and viral replication in the lungs of transgenic mice that express a human version of ACE2, confirming the pathogenicity of the virus in this model.

Tuberous sclerosis is a disease characterized by tumour-like growths in multiple organs and is caused by mutations in TSC1 or TSC2. Here, the authors solve the crystal structure of yeast TSC1 and find that most mutations are found inside the folded N-terminal ___domain.

Polygenic Risk Scores (PRS) show promise for facilitating cancer risk stratification. Here, the authors performed a large genome-wide association study and develop a PRS for nasopharyngeal carcinoma, which could improve risk stratification and personalized screening.

TAK1 is a key mediator of human inflammatory bowel diseases (IBD) through the NF-kB pathway. Here, the authors show that TAK1 phosphorylates TRADD, which cooperates with RIPK1 to intestinal pathology and inflammation in a mouse model of IBD.

The relationship between tissue-specific DNA methylation and cancer risk remains to be elucidated. Here, the authors predict DNA methylation at CpG sites for seven cancer types and investigate how these influence cancer risk.

An automated deep-learning pipeline for chest-X-ray-image standardization, lesion visualization and disease diagnosis can identify viral pneumonia caused by COVID-19, assess its severity, and discriminate it from other types of pneumonia.

Patients whose disease is diagnosed in its early stages have better outcomes. In this study, the authors develop a non invasive blood test based on circulating tumor DNA methylation that can potentially detect cancer occurrence even in asymptomatic patients.

A study presents the results of surveillance for SARS-CoV-2 in animal and environmental samples from a market linked to early human cases of coronavirus disease 2019.

Mental disorders are often linked with cardiometabolic disorders, but the mechanism remains unclear. Here, the authors use comprehensive health data from Denmark and to shed light on the genetic and environmental factors influencing the co-occurrence of six mental disorders and 15 cardiometabolic disorders.

α-ketoglutarate is an intermediate of the Krebs Cycle that was recently reported to extend lifespan in C.Elegans. Here, the authors show that administration of α-ketoglutarate to mice reduces age-related bone loss, by ameliorating senescence of bone-marrow derived mesenchymal stem cells.

In this study, the authors found five disease clusters associated with a prior diagnosis of anxiety/stress-related disorders, and identified several underlying genetic components. These findings may aid mechanistic exploration and risk management for health decline among those patients.

Chrysanthemum is an important ornamental species with great economic value. Here, the authors assemble the haploid genome of C. morifolium, reveal its segmental allopolyploid genomic composition (AA’B), and identify candidate genes associated with flower development, petal shape, and flower colour.

Epstein-Barr virus (EBV) is associated with high risk for nasopharyngeal carcinoma (NPC). Here, the authors develop a comprehensive risk score that combines risk effects of EBV and human genetics for NPC risk stratification.

Here, the authors characterize replication of SARS-CoV-2 in human airway epithelial (HAE) cultures and show that it can infect ciliated and secretory cells, affects transepithelial electrical resistance and causes plaque-like cytopathic effects associated with apoptosis.

Yao Zhao, Yongyong Shi and colleagues performed a genome-wide association study on sporadic pituitary adenoma in the Han Chinese population. They identify three new susceptibility loci.

Whole-genome sequencing and association analysis of 270 Epstein–Barr virus (EBV) isolates from China identify two non-synonymous EBV variants within BALF2 that are strongly associated with the risk of nasopharyngeal carcinoma.

A transformer-based representation-learning model that processes multimodal input in a unified manner outperformed non-unified multimodal models in two clinical diagnostic tasks.

Developing robust catalysts for direct synthesis of light olefins from syngas remains a challenge. Here, the authors report a novel bifunctional catalyst composed of ZnCr binary oxide and low-Si AlPO-18 zeolite which exhibits enhanced CO conversion and selectivity to C2-C4 olefins under mild reaction conditions.

Macrophage-to-myofibroblast transition (MMT) contributes to CaOx-induced fibrosis in nephrocalcinosis. EZH2 is the critical regulator that promotes kidney fibrosis by meditating MMT via the DUSP23/SMAD3 pathway.

Size and charge can significantly affect delivery of therapeutic agents to tumours. Here, the authors report on nanoparticles optimised for delivery to the tumour which release smaller particles and change charge in the tumour microenvironment to optimise tumour penetration and cellular uptake.

Antimony trisulfide has a proper bandgap of 1.7 eV for making solar cells but the devices suffer from severe voltage loss. Here Yang et al. propose that the photoexcited carriers are self-trapped by lattice deformation, which places a thermodynamic limit of only 0.8 V for the open circuit voltage.

Studies of the genetic association between vitamin D and cancer risk have typically been underpowered. Here the authors analyse this using Mendelian Randomisation with more than 70 vitamin D variants obtained from the UK Biobank and large-scale data from various consortia, confirming null associations between vitamin D and most cancers.

Gastroesophageal reflux disease (GERD) is a major risk factor for Barret’s esophagus (BE) and esophageal adenocarcinoma (EA). Here, An et al. report 25 genetic loci for GERD, many of which associate with BE and EA or with other traits such as BMI.

The Sequencing Quality Control (SEQC) consortium shows that junction discovery and differential gene expression profiling with RNA-seq can be robust but transcript-level and absolute measurements remain challenging.

Thomas Vaughan and colleagues report a genome-wide association study of esophageal adenocarcinoma together with its precancerous lesion, Barrett's esophagus. They identified three loci associated with susceptibility to this cancer.

Peter Donnelly and colleagues report a genome-wide association study for Barrett's esophagus, a common premalignant condition associated with stomach acid reflux and predisposing to esophageal adenocarcinoma. They identify two loci associated with susceptibility to Barrett's esophagus.

Magnetic reconnection drives the ejection of plasmas during solar flares through changes in the magnetic fields. Here, the authors use a laboratory-based experiment to create magnetic reconnection in a regime in which the plasma on one side of the reconnection is in a strongly collisional state, while it is weakly-collisional or collisionless on the other.