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Signal Transduction and Targeted Therapy (14)
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Showing 1–50 of 57 results

Advanced filters: Author: Weiqi Hong Clear advanced filters

Single-cell profiling identifies hair cell SLC35F1 deficiency as a signature of primate cochlear aging

Sun, Fu, Zheng, Hong, Liu et al. generate a single-nucleus transcriptomic atlas of the primate cochlear aging, identifying an age-related decline in Slc35f1 and showing that silencing Slc35f1 in mice induces hair cell degeneration and auditory deficits.

Guoqiang Sun
Xiaolong Fu
Guang-Hui Liu
Research20 Jun 2025
Nature Aging

P: 1-18
A strong but uneven increase in urban tree cover in China over the recent decade

Trees enrich cities, contributing to urban ecosystems and to the health of urban populations. This study quantifies urban tree coverage in all major Chinese cities, finding that greening efforts are successful but that certain mega-cities are benefiting more.

Xiaoxin Zhang
Martin Brandt
Rasmus Fensholt
Research22 Apr 2025
Nature Cities

Volume: 2, P: 460-469
Substrate recognition and cleavage mechanism of the monkeypox virus core protease

Structural and biochemical studies of the monkeypox virus core protease show that it exists as an active homodimer and indicate that the substrate-binding sites of core proteases are a promising target for antiviral drugs.

Yan Gao
Xiong Xie
Haitao Yang
Research22 Apr 2025
Nature

Volume: 643, P: 271-279
Trivalent recombinant protein vaccine induces cross-neutralization against XBB lineage and JN.1 subvariants: preclinical and phase 1 clinical trials

SARS-CoV-2 evolves into new subtypes necessitating further vaccine development. Here the authors generate a trivalent vaccine with Receptor Binding Domains from Delta, BA.5 and XBB.1.5 variants and characterize immunogenicity and protection in mice and safety in a phase I vaccine trial in humans.

Jingyun Yang
Weiqi Hong
Xiawei Wei
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-18
Author Correction: Biomimetic olfactory chips based on large-scale monolithically integrated nanotube sensor arrays

Chen Wang
Zhesi Chen
Zhiyong Fan
Amendments and Corrections20 Aug 2024
Nature Electronics

Volume: 7, P: 842
Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine

Somatostatin receptor 2 (SSTR2) represents a therapeutic target of neuroendocrine tumors. Here, authors report two structures of SSTR2 bound to peptide octreotide and small molecule paltusotine, revealing the basis subtype selectivity and signal bias properties.

Jie Zhao
Hong Fu
Zhenhua Shao
ResearchOpen Access21 Feb 2023
Nature Communications

Volume: 14, P: 1-14
Biomimetic olfactory chips based on large-scale monolithically integrated nanotube sensor arrays

A biomimetic olfactory system that integrates nanotube sensor arrays with up to 10,000 individually addressable sensors per chip can offer high sensitivity to various gases with excellent distinguishability for mixed gases and 24 distinct odours.

Chen Wang
Zhesi Chen
Zhiyong Fan
Research10 Jan 2024
Nature Electronics

Volume: 7, P: 157-167
A self-assembled trimeric protein vaccine induces protective immunity against Omicron variant

The SARS-CoV-2 Omicron variant has quickly become the predominant circulating variant, due to the high transmissibility and immune escape. Here, the authors develop a trimeric protein vaccine candidate and show a sustained humoral immune response, and protection from challenge (Omicron and Delta) in various animal models.

Cai He
Jingyun Yang
Xiawei Wei
ResearchOpen Access17 Sept 2022
Nature Communications

Volume: 13, P: 1-14
Machine learning of genomic features in organotropic metastases stratifies progression risk of primary tumors

The ___location and timing of metastasis are still fundamentally unpredictable. Here the authors present the Metastatic Network model, a machine learning framework that integrates clinical data and DNA alterations to predict the risk of metastasis to specific organs as well as clinical outcomes

Biaobin Jiang
Quanhua Mu
Jiguang Wang
ResearchOpen Access18 Nov 2021
Nature Communications

Volume: 12, P: 1-15
A recombinant protein vaccine induces protective immunity against SARS-CoV-2 JN.1 and XBB-lineage subvariants

Jingyun Yang
Weiqi Hong
Xiawei Wei
ResearchOpen Access26 Feb 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-15
A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy

Zhenglin Yang and colleagues use whole-exome sequencing to identify a rare variant in the FGD6 gene that is associated with the polypoidal choroidal vasculopathy subtype of wet age-related macular degeneration. They show that FGD6 regulates proangiogenic effects together with VEGF and that the mutation results in abnormal retinal vessel development.

Lulin Huang
Houbin Zhang
Zhenglin Yang
Research18 Apr 2016
Nature Genetics

Volume: 48, P: 640-647
Automatic detection of 39 fundus diseases and conditions in retinal photographs using deep neural networks

Systems for automatic detection of a single disease may miss other important conditions. Here, the authors show a deep learning platform can detect 39 common retinal diseases and conditions.

Ling-Ping Cen
Jie Ji
Mingzhi Zhang
ResearchOpen Access10 Aug 2021
Nature Communications

Volume: 12, P: 1-13
A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

A recombinant vaccine that targets the receptor-binding ___domain of the spike protein of SARS-CoV-2 induces a potent antibody response in immunized mice, rabbits and non-human primates, and protects primates from infection with the virus.

Jingyun Yang
Wei Wang
Xiawei Wei
Research29 Jul 2020
Nature

Volume: 586, P: 572-577
Biomolecular condensates mediate bending and scission of endosome membranes

Plant ESCRT component FREE1 forms liquid-like condensates that associate with membranes to drive intraluminal vesicle formation.

Yanning Wang
Shulin Li
Xiaofeng Fang
ResearchOpen Access09 Oct 2024
Nature

Volume: 634, P: 1204-1210
Cationic crosslinked carbon dots-adjuvanted intranasal vaccine induces protective immunity against Omicron-included SARS-CoV-2 variants

Lei et al. show that intranasal immunisation with their vaccine candidate is able to broadly protect mice from SARS-CoV-2 infection, including Omicron variants.

Hong Lei
Aqu Alu
Xiawei Wei
ResearchOpen Access09 May 2023
Nature Communications

Volume: 14, P: 1-17
Prognostic factors associated with visual outcome of salvageable eyes with posttraumatic endophthalmitis

Xuehui Lu
Honghe Xia
Haoyu Chen
ResearchOpen Access03 Sept 2019
Scientific Reports

Volume: 9, P: 1-8
Publisher Correction: A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

Jingyun Yang
Wei Wang
Xiawei Wei
Amendments and Corrections19 Jan 2021
Nature

Volume: 590, P: E23
Risk factors for endophthalmitis requiring evisceration or enucleation

Xuehui Lu
Danny Siu-Chun Ng
Haoyu Chen
ResearchOpen Access15 Jun 2016
Scientific Reports

Volume: 6, P: 1-6
Intranasal delivery of a subunit protein vaccine provides protective immunity against JN.1 and XBB-lineage variants

Hong Lei
Weiqi Hong
Xiawei Wei
ResearchOpen Access20 Nov 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-13
Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a

Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a.

Ying Cheng
Zhi-Meng Wang
Peng Jin
Research05 Nov 2018
Nature Neuroscience

Volume: 21, P: 1689-1703
Relationship between Optical Intensity on Optical Coherence Tomography and Retinal Ischemia in Branch Retinal Vein Occlusion

Jian Chen
Weiqi Chen
Haoyu Chen
ResearchOpen Access25 Jun 2018
Scientific Reports

Volume: 8, P: 1-7
The structural and functional analysis of mycobacteria cysteine desulfurase-loaded encapsulin

Tang et al. present the isolation and characterization of an Mmp1 encapsulin system from Mycobacterium smegmatis, highlighting its structural and functional features. The study reveals the cryo-EM and crystal structures, offering insights into the role of Enc-CD-loaded encapsulin in sulfur storage, stress resistance, and potential therapeutic applications against mycobacterial infections.

Yanting Tang
Yanyan Liu
Zihe Rao
ResearchOpen Access19 Dec 2024
Communications Biology

Volume: 7, P: 1-14
Prediction of spontaneous closure of traumatic macular hole with spectral ___domain optical coherence tomography

Haoyu Chen
Weiqi Chen
Lei Zhu
ResearchOpen Access21 Jul 2015
Scientific Reports

Volume: 5, P: 1-6
Quantitative analysis of retinal layers' optical intensities on 3D optical coherence tomography for central retinal artery occlusion

Haoyu Chen
Xinjian Chen
Milan Sonka
ResearchOpen Access18 Mar 2015
Scientific Reports

Volume: 5, P: 1-6
Fast sulfate formation from oxidation of SO₂ by NO₂ and HONO observed in Beijing haze

How sulfur dioxide emitted through coal combustion is oxidized to sulfate particles during winter haze pollution events has been the subject of debate. Here, the authors show that rapid oxidation takes place by nitrogen dioxide and nitrous acid, producing nitrous oxide together with sulfate.

Junfeng Wang
Jingyi Li
Daniel J. Jacob
ResearchOpen Access05 Jun 2020
Nature Communications

Volume: 11, P: 1-7
General synthesis of two-dimensional van der Waals heterostructure arrays

A general strategy for the synthesis of two-dimensional van der Waals heterostructure arrays is used to produce high-performance electronic devices, showing the potential of this scalable approach for practical technologies.

Jia Li
Xiangdong Yang
Xiangfeng Duan
Research11 Mar 2020
Nature

Volume: 579, P: 368-374
Possible Luttinger liquid behavior of edge transport in monolayer transition metal dichalcogenide crystals

Though metallic edge states in monolayer transition metal dichalcogenide have been observed before, how these states contribute to charge transport remains unclear. Here, the authors quantify the edge state contribution to electrical transport in monolayer MoS₂/WSe₂ field-effect transistors, revealing a dominated non-linear edge transport at low temperature, indicating possible Luttinger liquid behavior.

Guanhua Yang
Yan Shao
Ming Liu
ResearchOpen Access31 Jan 2020
Nature Communications

Volume: 11, P: 1-7
The Aging Biomarker Consortium represents a new era for aging research in China

Jie Ren
Moshi Song
Guang-Hui Liu
Correspondence19 Jul 2023
Nature Medicine

Volume: 29, P: 2162-2165
Molecular Characterization of NF1 and Neurofibromatosis Type 1 Genotype-Phenotype Correlations in a Chinese Population

Jia Zhang
Hanxing Tong
Zhirong Yao
ResearchOpen Access09 Jun 2015
Scientific Reports

Volume: 5, P: 1-5
Engineered mitochondria exert potent antitumor immunity as a cancer vaccine platform

Jingwen Luo
Fei Mo
Xiawei Wei
ResearchOpen Access20 Aug 2024
Cellular & Molecular Immunology

Volume: 21, P: 1251-1265
A mouse model for SARS-CoV-2-induced acute respiratory distress syndrome

Weiqi Hong
Jingyun Yang
Xiawei Wei
ResearchOpen Access01 Jan 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-3
Low levels of neutralizing antibodies against XBB Omicron subvariants after BA.5 infection

Jingyun Yang
Weiqi Hong
Xiawei Wei
ResearchOpen Access19 Jun 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-12
Incidence and impact factors of intraoperative loss of light perception under sub-Tenon’s anesthesia in patients with macular diseases

Dezhi Zheng
Zijing Huang
Weiqi Chen
ResearchOpen Access20 Jun 2019
Eye

Volume: 33, P: 1784-1790
Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells

Weiqi Hong
Jingyun Yang
Xiawei Wei
ResearchOpen Access10 Mar 2022
Cellular & Molecular Immunology

Volume: 19, P: 577-587
Classifying gastric cancer using FLORA reveals clinically relevant molecular subtypes and highlights LINC01614 as a biomarker for patient prognosis

Yiyun Chen
Wing Yin Cheng
Jiguang Wang
ResearchOpen Access19 Mar 2021
Oncogene

Volume: 40, P: 2898-2909
Spontaneous apoptosis of cells in therapeutic stem cell preparation exert immunomodulatory effects through release of phosphatidylserine

Xuemei He
Weiqi Hong
Xiawei Wei
ResearchOpen Access14 Jul 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-14
RIP3-mediated microglial necroptosis promotes neuroinflammation and neurodegeneration in the early stages of diabetic retinopathy

Zijing Huang
Jiajian Liang
Dingguo Huang
ResearchOpen Access29 Mar 2023
Cell Death & Disease

Volume: 14, P: 1-11
A heterozygous moth genome provides insights into herbivory and detoxification

Minsheng You and colleagues report the whole-genome sequence of the diamondback moth, Plutella xylostella. Their transcriptome analysis from different life stages, together with comparative genomic and phylogenetic analysis, provides insights into herbivore evolution and insect adaptation to plant feeding and detoxification.

Minsheng You
Zhen Yue
Jun Wang
ResearchOpen Access13 Jan 2013
Nature Genetics

Volume: 45, P: 220-225
Tripterin liposome relieves severe acute respiratory syndrome as a potent COVID-19 treatment

Haiying Que
Weiqi Hong
Xiawei Wei
ResearchOpen Access24 Dec 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-14
Cationic nanocarriers as potent adjuvants for recombinant S-RBD vaccine of SARS-CoV-2

Hong Lei
Aqu Alu
Xiawei Wei
ResearchOpen Access11 Dec 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-3
Inactivated SARS-CoV-2 induces acute respiratory distress syndrome in human ACE2-transgenic mice

Zhenfei Bi
Weiqi Hong
Xiawei Wei
ResearchOpen Access24 Dec 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-12
Association of periodontitis with all-cause and cause-specific mortality among individuals with depression: a population-based study

Yonghuan Zhang
Shanfeng Lin
Li Lin
ResearchOpen Access19 Sept 2024
Scientific Reports

Volume: 14, P: 1-12
Spike protein of SARS‐CoV‐2 Omicron (B.1.1.529) variant has a reduced ability to induce the immune response

Cai He
Xuemei He
Xiawei Wei
ResearchOpen Access09 Apr 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-4
Sport–gender stereotypes and their impact on impression evaluations

Zhiyuan Liu
Menglu Shentu
Weiqi Zheng
ResearchOpen Access26 Sept 2023
Humanities and Social Sciences Communications

Volume: 10, P: 1-14
Correction: Spontaneous apoptosis of cells in therapeutic stem cell preparation exert immunomodulatory effects through release of phosphatidylserine

Xuemei He
Weiqi Hong
Xiawei Wei
Amendments and CorrectionsOpen Access13 Jan 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-2
Response to Comment on: Quantification of anterior chamber reaction after intravitreal injections of conbercept and ranibizumab: a pilot study

Xulong Liao
Chuang Jin
Haoyu Chen
Correspondence30 Oct 2019
Eye

Volume: 34, P: 1485
Solar thermotherapy reduces the titer of Candidatus Liberibacter asiaticus and enhances canopy growth by altering gene expression profiles in HLB-affected citrus plants

Melissa M Doud
Yungsheng Wang
Yongping Duan
ResearchOpen Access27 Sept 2017
Horticulture Research

Volume: 4, P: 1-9
Neurological complications and infection mechanism of SARS-CoV-2

Dandan Wan
Tingfu Du
Xiaozhong Peng
ReviewsOpen Access23 Nov 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-16
Multi-scale factors influencing the characteristics of avian communities in urban parks across Beijing during the breeding season

Shilin Xie
Fei Lu
Zhiyun Ouyang
ResearchOpen Access11 Jul 2016
Scientific Reports

Volume: 6, P: 1-9
JMJD6 in tumor-associated macrophage regulates macrophage polarization and cancer progression via STAT3/IL-10 axis

Siyuan Chen
Manni Wang
Xiawei Wei
ResearchOpen Access11 Aug 2023
Oncogene

Volume: 42, P: 2737-2750

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