Oncolytic adenoviruses (Ads)-mediated anti-tumor activity is related to virus-promoted autophagy in tumor cells. Here the authors describe the design of a microbial nanocomposite based on Ads-encapsulated in bacterial outer membrane vesicles to promote Ads intratumoral accumulation and induction of autophagy, promoting anti-tumor immune responses in preclinical cancer models.
- Weiyue Ban
- Mengchi Sun
- Jin Sun
