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Author Correction: PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

Shunlei Duan
Guohong Yuan
Guang-Hui Liu
Amendments and CorrectionsOpen Access20 Jun 2025
Nature Communications

Volume: 16, P: 1
Proteolysis-targeting chimera against BCL-X_L destroys tumor-infiltrating regulatory T cells

Targeting regulatory T cells (Treg) represents a therapeutic option to abrogate tumor-associated immune suppression. Here the authors show that pharmacological degradation of BCL-X_L preferentially induces apoptosis of tumor-infiltrating Treg, promoting CD8 T cell activation and anti-tumor immune responses in preclinical cancer models.

Ryan Kolb
Umasankar De
Weizhou Zhang
ResearchOpen Access24 Feb 2021
Nature Communications

Volume: 12, P: 1-9
PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

The tumor suppressor PTEN is often mutated or lost in glioblastoma. Here, the authors demonstrate that in neuronal stem cells PTEN trans-represses PAX7gene expression and PTEN deficiency promotes PAX7-dependent neoplastic transformation.

Shunlei Duan
Guohong Yuan
Guang-Hui Liu
ResearchOpen Access03 Dec 2015
Nature Communications

Volume: 6, P: 1-14
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,

Simultaneous targeting of BCL-xL and BCL-2 is an attractive approach for cancer treatment. Based on information gained by computational structure modelling, the authors develop a PROTAC that induces degradation of both BCL-xL and BCL-2 and effectively targets BCL-xL/2-dependent leukaemia cells.

Dongwen Lv
Pratik Pal
Daohong Zhou
ResearchOpen Access25 Nov 2021
Nature Communications

Volume: 12, P: 1-14
FICTURE: scalable segmentation-free analysis of submicron-resolution spatial transcriptomics

FICTURE is a segmentation-free approach for identifying tissue architecture in spatial transcriptomics data. FICTURE is compatible with both imaging-based and sequencing-based methods and is uniquely suited for handling the largest available datasets.

Yichen Si
ChangHee Lee
Hyun Min Kang
Research12 Sept 2024
Nature Methods

Volume: 21, P: 1843-1854
Author Correction: Chiral recognition and enantiomer excess determination based on emission wavelength change of AIEgen rotor

Ming Hu
Ying-Xue Yuan
Yan-Song Zheng
Amendments and CorrectionsOpen Access05 May 2020
Nature Communications

Volume: 11, P: 1
A selective BCL-X_L PROTAC degrader achieves safe and potent antitumor activity

The first BCL-X_L-degrading PROTAC achieves safer and more potent antitumor activity than dual BCL-X_L and BCL-2 inhibitor navitoclax because of reduced dose-limiting platelet toxicity and high target specificity.

Sajid Khan
Xuan Zhang
Daohong Zhou
Research02 Dec 2019
Nature Medicine

Volume: 25, P: 1938-1947
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells

Regulatory T (Treg) cells are important modulators of the tumor microenvironment. Here the authors perform transcriptome profiling of immune cells from patients with renal clear cell carcinoma to find a Treg signature that correlates with poorer prognosis, with CD177 being implicated as the main mediator for related alterations in Treg activity and tumor outcome.

Myung-Chul Kim
Nicholas Borcherding
Weizhou Zhang
ResearchOpen Access01 Oct 2021
Nature Communications

Volume: 12, P: 1-13
Obesity-associated NLRC4 inflammasome activation drives breast cancer progression

Obesity is associated with higher breast cancer risk and poor prognosis. Here, the authors show that obesity promotes breast cancer through the recruitment of macrophages with activated NLRC4 inflammasome, which activate IL-1β production, resulting in VEGFA expression in adipocytes and angiogenesis.

Ryan Kolb
Liem Phan
Weizhou Zhang
ResearchOpen Access06 Oct 2016
Nature Communications

Volume: 7, P: 1-12
The GPR171 pathway suppresses T cell activation and limits antitumor immunity

Proliferative and effector functions of T cells are determined by T cell receptor signalling and modulated by activator and inhibitory co-receptors. Authors report here that the G-protein-coupled receptor GPR171 functions as a co-inhibitor of T cell signalling and might serve as a target for cancer immunotherapy.

Yuki Fujiwara
Robert J. Torphy
Yuwen Zhu
ResearchOpen Access06 Oct 2021
Nature Communications

Volume: 12, P: 1-14
Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling

In a mouse model of Erbb2-driven mammary tumours, this study finds a role for RANKL in the formation of lung metastases. RANKL is produced by regulatory T cells infiltrating the primary tumours and acts via its receptor RANK expressed on the cancer cells. Targeting RANKL may therefore prove useful in reducing breast cancer metastases.

Wei Tan
Weizhou Zhang
Michael Karin
Research16 Feb 2011
Nature

Volume: 470, P: 548-553
An ultra-high gain single-photon transistor in the microwave regime

Successfully controlling an optical signal by a single gate photon would have great applicability for quantum networks and all-optical computing. Here, the authors realise a single-photon transistor in the microwave regime based on superconducting quantum circuits.

Zhiling Wang
Zenghui Bao
Luming Duan
ResearchOpen Access15 Oct 2022
Nature Communications

Volume: 13, P: 1-7
Chiral recognition and enantiomer excess determination based on emission wavelength change of AIEgen rotor

Artificial receptors for chiral recognition are important in enantiomer excess analysis but current artificial detectors are based on fluorescence intensity changes only. Here the authors propose a different detection mechanism based on change of the fluorescence emission wavelength of an AIEgen rotor.

Ming Hu
Ying-Xue Yuan
Yan-Song Zheng
ResearchOpen Access09 Jan 2020
Nature Communications

Volume: 11, P: 1-10
Nonlinearity synergy: An elegant strategy for realizing high-sensitivity and wide-linear-range pressure sensing

The development of flexible pressure sensors with a wide linear range and high sensitivity is challenging. Chen et al. demonstrate a sensor for robotics and wearable devices, using nonlinear elasticity of an elastic spacer as a stiffness regulator and a microstructured sensing layer with non-linear piezoresistivity.

Rui Chen
Tao Luo
Wei Zhou
ResearchOpen Access20 Oct 2023
Nature Communications

Volume: 14, P: 1-9
Evaluation of urinary inflammatory index in rapid screening of urinary tract infection

Wanjian Gu
Weizhou Huang
Liang Ge
ResearchOpen Access09 Nov 2020
Scientific Reports

Volume: 10, P: 1-7
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

Suppression of the kinase NIK prevents NF-κB signaling. The Cheng and Karin labs demonstrate that adaptor proteins TRAF2 and TRAF3 and ubiquitin ligases cIAP1 and cIAP2 regulate NIK degradation.

Sivakumar Vallabhapurapu
Atsushi Matsuzawa
Michael Karin
Research09 Nov 2008
Nature Immunology

Volume: 9, P: 1364-1370
Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

TLR4 signals via MyD88 and TRIF to activate proinflammatory cytokine and type I interferon responses. Karin and colleagues show that different ubiquitination of TRAF3 via K48 or K63 dictates the ensuing immune response.

Ping-Hui Tseng
Atsushi Matsuzawa
Michael Karin
Research08 Nov 2009
Nature Immunology

Volume: 11, P: 70-75
Deciphering the impact of genomic variation on function

The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

Jesse M. Engreitz
Heather A. Lawson
Ella K. Samer
Reviews04 Sept 2024
Nature

Volume: 633, P: 47-57
Finger-inspired rigid-soft hybrid tactile sensor with superior sensitivity at high frequency

Designing efficient tactile sensors under high-frequency dynamic stimuli remains a challenge. Here, the authors demonstrate piezoelectric tactile sensor with sensitivity of 346.5 pCN−1, wide bandwidth of 5–600 Hz and a linear force detection range of 0.009–4.3 N using a rigid-soft hybrid force-transmission-layer in combination with a soft bottom substrate.

Jinhui Zhang
Haimin Yao
Wei Zhou
ResearchOpen Access29 Aug 2022
Nature Communications

Volume: 13, P: 1-9
Single-cell transcriptomics unveil profiles and interplay of immune subsets in rare autoimmune childhood Sjögren’s disease

This study maps the peripheral immune landscape of childhood Sjogren’s disease at single-cell level, providing immune and molecular characterizations that necessitate a better understanding in the etiology of the rare autoimmune disease.

Myung-Chul Kim
Umasankar De
Seunghee Cha
ResearchOpen Access19 Apr 2024
Communications Biology

Volume: 7, P: 1-14
Environmental factors shape the epiphytic bacterial communities of Gracilariopsis lemaneiformis

Pengbing Pei
Muhammad Aslam
Weizhou Chen
ResearchOpen Access21 Apr 2021
Scientific Reports

Volume: 11, P: 1-15
Mapping the immune environment in clear cell renal carcinoma by single-cell genomics

Borcherding and Vishwakarma et al. characterize the tumor immune microenvironment in treatment-naïve clear cell renal carcinoma patients using single-cell RNA- and T-cell receptor sequencing. They find CD8 + T cells and macrophages are enriched in tumor tissue, and identify a proliferative CD8 + T-cell population, which may be relevant for anti-cancer responses.

Nicholas Borcherding
Ajaykumar Vishwakarma
Weizhou Zhang
ResearchOpen Access27 Jan 2021
Communications Biology

Volume: 4, P: 1-11
Co-targeting BCL-X_L and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice

Sajid Khan
Patrick Kellish
Daohong Zhou
ResearchOpen Access02 Jan 2023
Cell Death Discovery

Volume: 9, P: 1-10
Studies on the damping properties of polyacrylate emulsion/hindered phenol hybrids

Irganox-1035 has a positive effect on damping performance of PAE/Irganox-1035 hybrids. When the Irganox-1035 amount in PAE/Irganox-1035 hybrids increases from 0 to 70 phr, the tanδ values increase from 2.2 to 4.2, demonstrating PAE/Irganox-1035 hybrids are promising damping materials. Meanwhile, the single loss factor also indicates Irganox-1035 has a good compatiblity with PAE.

Xu Zhou
Guixin Zhang
Jikui Wang
Research14 Mar 2012
Polymer Journal

Volume: 44, P: 382-387
Cancer cell-intrinsic function of CD177 in attenuating β-catenin signaling

Paige N. Kluz
Ryan Kolb
Weizhou Zhang
Research10 Feb 2020
Oncogene

Volume: 39, P: 2877-2889
“TET-on” pluripotency

Recent studies have uncovered a specific role of TET proteins in reprogramming somatic cells to induced pluripotent stem cells, a process where O-linked β-N-acetylglucosamine transferase may play a crucial role.

Ping Wang
Jing Qu
Juan Carlos Izpisua Belmonte
Research Highlights04 Jun 2013
Cell Research

Volume: 23, P: 863-865
Body fatness and mTOR pathway activation of breast cancer in the Women’s Circle of Health Study

Ting-Yuan David Cheng
Angela R. Omilian
Christine B. Ambrosone
ResearchOpen Access21 Sept 2020
npj Breast Cancer

Volume: 6, P: 1-9
Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4

Ryan Kolb
Paige Kluz
Weizhou Zhang
Research05 Dec 2018
Oncogene

Volume: 38, P: 2351-2363
Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding

Jiping Yang
Jingyi Li
Guang-Hui Liu
Correspondence07 Jul 2017
Cell Research

Volume: 27, P: 1178-1181
Visualization of aging-associated chromatin alterations with an engineered TALE system

Ruotong Ren
Liping Deng
Guang-Hui Liu
ResearchOpen Access31 Jan 2017
Cell Research

Volume: 27, P: 483-504
SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

Huize Pan
Di Guan
Guang-Hui Liu
ResearchOpen Access15 Jan 2016
Cell Research

Volume: 26, P: 190-205
Reprogramming based gene therapy for inherited red blood cell disorders

Hematopoietic stem cell transplantation remains the only curative therapy for certain genetic diseases of the hematopoietic system, including some inheritable deficiencies in red blood cells (RBC). Recent advances in induced pluripotent stem cells may open a new era for the cure of such severe genetic RBC diseases.

Xiuling Xu
Jing Qu
Juan Carlos Izpisua Belmonte
Research Highlights03 Apr 2012
Cell Research

Volume: 22, P: 941-944
Switching cell fate, ncRNAs coming to play

D Guan
W Zhang
J C Izpisua Belmonte
ReviewsOpen Access17 Jan 2013
Cell Death & Disease

Volume: 4, P: e464

Search

Author Correction: PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

Proteolysis-targeting chimera against BCL-X_L destroys tumor-infiltrating regulatory T cells

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,

FICTURE: scalable segmentation-free analysis of submicron-resolution spatial transcriptomics

Author Correction: Chiral recognition and enantiomer excess determination based on emission wavelength change of AIEgen rotor

A selective BCL-X_L PROTAC degrader achieves safe and potent antitumor activity

CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells

Obesity-associated NLRC4 inflammasome activation drives breast cancer progression

The GPR171 pathway suppresses T cell activation and limits antitumor immunity

Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling

An ultra-high gain single-photon transistor in the microwave regime

Chiral recognition and enantiomer excess determination based on emission wavelength change of AIEgen rotor

Nonlinearity synergy: An elegant strategy for realizing high-sensitivity and wide-linear-range pressure sensing

Evaluation of urinary inflammatory index in rapid screening of urinary tract infection

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

Deciphering the impact of genomic variation on function

Finger-inspired rigid-soft hybrid tactile sensor with superior sensitivity at high frequency

Single-cell transcriptomics unveil profiles and interplay of immune subsets in rare autoimmune childhood Sjögren’s disease

Environmental factors shape the epiphytic bacterial communities of Gracilariopsis lemaneiformis

Mapping the immune environment in clear cell renal carcinoma by single-cell genomics

Co-targeting BCL-X_L and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice

Studies on the damping properties of polyacrylate emulsion/hindered phenol hybrids

Cancer cell-intrinsic function of CD177 in attenuating β-catenin signaling

“TET-on” pluripotency

Body fatness and mTOR pathway activation of breast cancer in the Women’s Circle of Health Study

Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4

Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding

Visualization of aging-associated chromatin alterations with an engineered TALE system

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

Reprogramming based gene therapy for inherited red blood cell disorders

Switching cell fate, ncRNAs coming to play

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