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Showing 1–10 of 10 results
Advanced filters: Author: Wenan Chen Clear advanced filters

  • The availability of relevant animal models that can recapitulate high-risk hepatoblastoma will help to better understand its pathogenesis. Here the authors report and characterize a hepatocyte-specific, MYC-driven hepatoblastoma mouse model and show it recapitulates the human hepatoblastoma pathophysiology.

    • Jie Fang
    • Shivendra Singh
    • Jun Yang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-27

  • Results from a comprehensive evaluation of the function of BRCA2 variants, particularly variants of uncertain significance, provide a useful resource to improve the clinical management of individuals who carry such genetic variants.

    • Huaizhi Huang
    • Chunling Hu
    • Fergus J. Couch
    ResearchOpen Access
    Nature
    Volume: 638, P: 528-537

  • Hydroxyl radicals are reactive species capable of water purification and disinfection, although their generation, particularly through renewable approaches, is challenging. Now, low-valent Au on potassium-incorporated carbon nitride has been shown to produce hydroxyl radicals upon solar illumination and to provide high water disinfection rates.

    • Zhenyuan Teng
    • Hongbin Yang
    • Bin Liu
    Research
    Nature Chemistry
    Volume: 16, P: 1250-1260

  • Phenotypically, transcriptionally and metabolically diverse subsets of TH17 cells develop in a chronic autoimmune disease: one subset has inferred stemness features and low anabolic metabolism, while a reciprocal subset has higher metabolic activity that supports transdifferentiation into TH1 cells.

    • Peer W. F. Karmaus
    • Xiang Chen
    • Hongbo Chi
    Research
    Nature
    Volume: 565, P: 101-105

  • Fine-mapping is the process by which a trait-associated region from a genome-wide association study (GWAS) is analysed to identify the particular genetic variants that are likely to causally influence the examined trait. This Review discusses the diverse statistical approaches to fine-mapping and their foundations, strengths and limitations, including integration of trans-ethnic human population data and functional annotations.

    • Daniel J. Schaid
    • Wenan Chen
    • Nicholas B. Larson
    Reviews
    Nature Reviews Genetics
    Volume: 19, P: 491-504

  • In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

    • Jacob Beal
    • Natalie G. Farny
    • Jiajie Zhou
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-29