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Understanding magnetic materials at the nanoscale is important for the development of novel applications, but has been hampered by a lack of suitable experimental techniques. Here, the use of transmitted electrons permits the determination of atomic site-specific magnetic information.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

A ‘smart’ toilet that uses pressure and motion sensors, biometric identification, urinalysis strips, a computer-vision uroflowmeter and machine learning longitudinally tracks biomarkers of health and disease in the user’s urine and stool.

The CMS Collaboration reports the study of three simultaneous hard interactions between quarks and gluons in proton–proton collisions. This manifests through the concurrent production of three J/ψ mesons, which consist of a charm-quark–antiquark pair.

Free-electron lasers are capable of high repetition rates and it is assumed that protein crystals often do not survive the first X-ray pulse. Here the authors address these issues with a demonstration of multi-hit serial crystallography in which multiple FEL pulses interact with the sample without destroying it.

Tumor-reactive T cell receptors are rapidly identified from lymphocyte scRNA-seq data.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

The interaction between antiferromagnetic magnons and electrons sits at the heart of many strongly correlated systems, however, investigation has been hampered by a lack of clear-cut examples. Here, Yu et al directly observe a kink in the dispersion, a result of renormalization due to the electron-antiferromagnetic magnon interaction.

The authors study the dynamics of 80 nm-size skyrmions in a 100 nm-wide track by electrical Lorentz transmission electron microscopy. They show that the skyrmions can be moved by nanosecond current pulse without experiencing the skyrmion Hall effect.

Reaching a quantum advantage in metrology usually requires hard-to-prepare two-mode entangled states such as NOON states. Here, instead, the authors demonstrate single-mode phase estimation using Fock states superpositions in a superconducting qubit-oscillator system.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

Translation inhibition is a strategy for organisms to overcome various environmental stresses including viral infections. Here the authors show that a tRNA/rRNA-targeting RNase Schlafen13 inhibits protein synthesis by directly digesting cytoplasmic tRNA and rRNA with the ability to restrict viral propagation.

Low effective doping of boron limits the performance of solar cells based on hydrogenated amorphous silicon. Liu et al. show that light induces the diffusion of hydrogen atoms, which activates boron doping, enabling a power conversion efficiency of over 25%.

The mechanism of enhanced superconducting transition temperature (T_c) at the FeSe/SrTiO₃ interface remains enigmatic. Here, Song and Yu et al. reveal the evidence of cooperation between intrinsic pairing interaction in FeSe and interfacial electron–phonon coupling to enhance the T_c at the FeSe/SrTiO₃ interface.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

In the typical spin-hall effect, spin-current, charge current, and spin polarisation are all mutually perpendicular, a feature enforced by symmetry. Here, using an anti-ferromagnet with a triangular spin structure, the authors demonstrate a spin-hall effect without a perpendicular spin alignment.

The anisotropic electrical and optical response of materials has allowed for the development of variety of sensors, memories and other interesting devices. Here, Qi et al turn their attention to the van der Waals antiferromagnetic insulator CrPS₄, and demonstrate a very large, electrically tunable anisotropy in magnon transport, and present a multibit read-only memory based on this anisotropy.

Electron doping is a powerful way to induce quantum phase transitions in materials and explore exotic states of matter. Here, Wen et al. present carefully-controlled potassium dosing in FeSe films and FeSe_0.93S_0.07bulk, which enhances superconductivity and induces other anomalous phases, revealing a complex phase diagram.

An antimatter hypernucleus formed by an anti-lambda hadron, an antiproton and two antineutrons was observed through its two-body decay after production in ultrarelativistic heavy-ion collisions.

The dynamics of liquid water is rich due to its complex, highly disordered hydrogen-bond network, which hasn’t been fully understood. Perakis et al. measure water dynamics at sub-100 fs and show that it cannot be described by simple thermal motion due to the build-up of tetrahedral structures upon supercooling.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

Rapid proton capture nucleosynthesis stalls at waiting-point nuclides, including ⁶⁴Ge. Precision mass measurements in the vicinity of this nuclide influence state-of-the-art calculations of X-ray bursts from accreting neutron stars.

2D nonlayered materials exhibit interesting properties for catalysis, nanoelectronics and spintronics applications, but their growth is still challenging. Here, the authors report a theoretical model and an experimental strategy to synthesize various 2D nonlayered transition metal oxides with room-temperature magnetic properties.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

An unsupervised, annotation-free method is developed that can identify microbial functional groups on the basis of variation in microbiome data and environmental variables. Here, the authors demonstrate its application in several different datasets including the Tara oceans microbiome and animal gut microbiomes.

Recent studies reported evidence of a new phase in the kagome metal CsV₃Sb₅ between the charge density wave and superconducting transitions. Here the authors reveal symmetry properties of this phase in CsV₃Sb₅ thin flakes probed by in-plane magnetotransport, suggesting a 3D orbital current order.

Sensitive, biocompatible and stable contrast agents for MRI are in demand. Here, the authors combine gadolinium ions with amorphous calcium carbonate to make stable paramagnetic amorphous carbonate nanoclusters with high MRI contrast and significantly improved biocompatibility over commercial gadolinium-based agents.

Insight-HXMT detected a double-peaked X-ray burst from Galactic magnetar SGR J1935+2154, consistent with two fast radio bursts (FRBs) observed from the same object within seconds. This coincidence suggests a common physical origin, and gives insight into the mechanism behind the origin of FRBs.

In this study, the authors found five disease clusters associated with a prior diagnosis of anxiety/stress-related disorders, and identified several underlying genetic components. These findings may aid mechanistic exploration and risk management for health decline among those patients.

As studies continue sequencing with deeper coverage, computational processing of these profiles has become increasingly resource consuming. Here the authors designed an efficient computational method called Chromap to align and preprocess high throughput sequencing data from chromatin profiling techniques, including ChIP-seq, Hi-C, or scATAC-seq, with a major decrease in runtime.

Shortening the inter-spin distance is an effective way to enhance magnetic coupling. However, it is typically challenging to change the inter-ion distance in most magnetic systems. Here, Huang et al present a strategy for enhancing magnetic interactions, by confining a molecular magnetic system inside a carbon fullerene cage, leading to enhanced magnetic properties.

Modules of foldable crystalline silicon solar cells retain their power-conversion efficiency after being subjected to bending stress or exposure to air-flow simulations of a violent storm.

Zinc batteries are receiving growing attention due to their sustainability merits not shared by lithium-ion technologies. Here the aqueous electrolyte design features unique solvation structures that render Zn–air pouch cell excellent cycling stability in a wide temperature range from −60 to 80 °C.

Assessing microbial water quality is an important approach to monitor potential risks to human and environmental health. The use of two human faecal bacteria as molecular indicators is shown to be more sensitive than conventional measures for detecting contamination on an extensive set of data.

Using spin-entangled baryon–antibaryon pairs, the BESIII Collaboration reports on high-precision measurements of potential charge conjugation and parity (CP)-symmetry-violating effects in hadrons.

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

The interplay between magnetism and charge density wave in the kagome magnet FeGe is under debate. By using elastic and inelastic X-ray scattering, angle-resolved photoemission spectroscopy, and first principles calculations, Miao et al. propose that the charge density wave is stabilized by spin-phonon coupling.

Previous work has shown in iPSC derived neurons that synaptic impairments are associated with a 4bp DISC1 deletion. Here the authors demonstrate a role for the PDE4 signalling pathway in these synaptic impairments.

Multiple molecular profiling methods are required to study urothelial non-muscle-invasive bladder cancer (NMIBC) due to its heterogeneity. Here the authors integrate multi-omics data of 834 NMIBC patients, identifying a molecular subgroup associated with multiple alterations and worse outcomes.

Some cancer patients first present with metastases where the ___location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

Finger millet is an orphan crop key to food security of people living in eastern Africa, India and Nepal. Here, the authors assemble its genome, conduct population genetics analyses to infer the diversification history, and reveal a candidate gene for purple coloration of anthers and stigma.