Fang and colleagues revealed cryo-electron microscopy structures of human THIK1, identifying two inner gates and a C-type selectivity filter gate, distinct from other two-pore-___domain potassium channels. Their findings uncover the channel gating mechanism, offering insights for developing THIK1-targeted neurotherapeutics.
- Xiangyun Fang
- Haichao Jin
- Baobin Li
