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Scientific Reports (21)
Acta Pharmacologica Sinica (12)
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Showing 1–50 of 90 results

Advanced filters: Author: Xiao-Jing Zhang Clear advanced filters

Up-expression of GAD65 in the Amygdala of the Rat Model of Chroric Immobilization Stress with Elevated Blood Glucose

Xiao-Jing Li
Wei Zhang
Xue Zhou
ResearchOpen Access05 Apr 2011
Nature Precedings

P: 1
Integrated proteogenomic characterization of localized prostate cancer identifies biological insights and subtype-specific therapeutic strategies

Prostate cancer is heterogenous in response to therapy. Here, the authors analyse genomics, transcriptomics, proteomics and phosphoproteomics data from 145 prostate cancer patients to identify NANS as a therapeutic target in prostate cancer.

Wei Ou
Xin-Xin Zhang
Zong-Ren Wang
ResearchOpen Access03 Apr 2025
Nature Communications

Volume: 16, P: 1-17
Correction: Corrigendum: Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates

Pi-Xiao Wang
Yan-Xiao Ji
Hongliang Li
Amendments and Corrections01 Oct 2017
Nature Medicine

Volume: 23, P: 1241
Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis

Ulcerations of the oral cavity, or oral mucositis, often occur during radiation treatment for cancers of the head or neck or during bone marrow transplantation. Xiao-Jing Wang and colleagues now show that in a mouse model, Smad7 is an effective treatment for this condition, offering more hope for its clinical management.

Gangwen Han
Li Bian
Xiao-Jing Wang
Research10 Mar 2013
Nature Medicine

Volume: 19, P: 421-428
Discovery of oscillations above 200 keV in a black hole X-ray binary with Insight-HXMT

Low-frequency quasiperiodic oscillations in X-ray data are thought to trace the accretion flow in X-ray binaries. Here, the detection of 200 keV oscillations probes the innermost regions of MAXI J1820+070, revealing the precession of a small-scale jet.

Xiang Ma
Lian Tao
Ren-Lin Zhuang
Research21 Sept 2020
Nature Astronomy

Volume: 5, P: 94-102
Tumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling

Phosphorylation of ACSL4 by mitochondria-located metabolic kinase PCK2 is critical to regulating ferroptosis-associated phospholipid remodeling in tumor-repopulating cells that are resistant to chemotherapy and radiotherapy.

Zhe Li
Zhi-min Xu
Zhuo-wei Liu
ResearchOpen Access08 May 2024
Nature Chemical Biology

Volume: 20, P: 1341-1352
A glutamatergic DRN–VTA pathway modulates neuropathic pain and comorbid anhedonia-like behavior in mice

The neural circuit mechanisms underlying chronic pain and comorbid anhedonia remain poorly understood. Here, the authors show the critical role of the DRN–VTA–NAcMed pathway in establishing and modulating chronic neuropathic pain and comorbid anhedonia.

Xin-Yue Wang
Wen-Bin Jia
Yan Zhang
ResearchOpen Access23 Aug 2023
Nature Communications

Volume: 14, P: 1-15
A circuit from the ventral subiculum to anterior hypothalamic nucleus GABAergic neurons essential for anxiety-like behavioral avoidance

Anxiety is thought to be evolutionarily rooted in predator defense. Yan et al. show that GABAergic neurons in the anterior hypothalamic nucleus (AHN), a node in the predator defense network, play an essential role in anxiety-like behaviors.

Jing-Jing Yan
Xiao-Jing Ding
Xiao-Hong Xu
ResearchOpen Access03 Dec 2022
Nature Communications

Volume: 13, P: 1-16
Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates

Targeting CFLAR in mouse and non-human primates ameliorates non-alcoholic steatohepatitis by decreasing JNK signaling in hepatocytes.

Pi-Xiao Wang
Yan-Xiao Ji
Hongliang Li
Research20 Feb 2017
Nature Medicine

Volume: 23, P: 439-449
The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling

TRAF6 is a ubiquitin E3 ligase regulating a number of biological processes. Here the authors show that ROS, generated during pathological cardiac stress, induces TRAF6 auto-ubiquitination and activation, promoting its interaction with and ubiquitination of TAK1 that contributes to development of cardiac hypertrophy.

Yan-Xiao Ji
Peng Zhang
Hongliang Li
ResearchOpen Access01 Jun 2016
Nature Communications

Volume: 7, P: 1-20
Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling

TRAF family proteins regulate immune signalling cascades. Here, the authors show that TRAF3 is upregulated in the liver in non-alcoholic fatty liver disease, promoting insulin resistance, inflammation and hepatic steatosis via its interaction with the kinase TAK1.

Pi-Xiao Wang
Xiao-Jing Zhang
Hongliang Li
ResearchOpen Access17 Feb 2016
Nature Communications

Volume: 7, P: 1-22
Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4

Toll-like receptor (TLR) 4 is a key mediator of non-alcoholic fatty liver disease progression. Targeting TLR4 degradation via the lysosome pathway improves outcome in mouse and monkey models of this condition.

Guang-Nian Zhao
Peng Zhang
Hongliang Li
Research08 May 2017
Nature Medicine

Volume: 23, P: 742-752
LncRNA TMPO-AS1 promotes esophageal squamous cell carcinoma progression by forming biomolecular condensates with FUS and p300 to regulate TMPO transcription

Xiao-Jing Luo
Ming-Ming He
Hui-Yan Luo
ResearchOpen Access27 Jun 2022
Experimental & Molecular Medicine

Volume: 54, P: 834-847
An ALOX12–12-HETE–GPR31 signaling axis is a key mediator of hepatic ischemia–reperfusion injury

ALOX12-mediated generation of 12-HETE leads to GPR31 activation and liver injury in ischemia–reperfusion, which can be targeted in a nonhuman primate model to improve outcome.

Xiao-Jing Zhang
Xu Cheng
Hongliang Li
Research11 Dec 2017
Nature Medicine

Volume: 24, P: 73-83
Dynamic molecular pockets on one-dimensional channels for splitting ethylene from C₂–C₄ alkynes

It is challenging to separate middle-sized molecules from complex mixtures using traditional molecular sieves. Here a metal–organic framework has been developed with dynamic molecular pockets that can adjust and accommodate alkynes preferentially, realizing efficient production of high-purity ethylene from its mixtures with alkynes regardless of their molecular sizes.

Heng Zeng
Xiao-Jing Xie
Dan Li
Research11 Jan 2024
Nature Chemical Engineering

Volume: 1, P: 108-115
Charge-to-mass Ratio of Saltating Particles in Wind-Blown Sand

Tian-Li Bo
Huan Zhang
Xiao-Jing Zheng
ResearchOpen Access07 Jul 2014
Scientific Reports

Volume: 4, P: 1-5
Author Correction: Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy

Ke-Qiong Deng
Aibing Wang
Hongliang Li
Amendments and CorrectionsOpen Access25 May 2023
Nature Communications

Volume: 14, P: 1-2
Polymorphisms of genes in nitric oxide-forming pathway associated with ischemic stroke in Chinese Han population

Jiang-tao Yan
Lan Zhang
Dao-wen Wang
Research03 Oct 2011
Acta Pharmacologica Sinica

Volume: 32, P: 1357-1363
Flexible gating between subspaces in a neural network model of internally guided task switching

The neural mechanism underlying flexible switching between different task rules is unclear. Here the authors analyzed trained modular recurrent neural network models with different cell types to reveal a circuit mechanism for uncued task switching.

Yue Liu
Xiao-Jing Wang
ResearchOpen Access01 Aug 2024
Nature Communications

Volume: 15, P: 1-20
Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy

Identifying pathways that cause pathological cardiac hypertrophy holds great therapeutic potential. Here the authors discover one such pathway and show that SIKE, an inhibitor of interferon signalling, prevents pathological but not physiological cardiac hypertrophy by interacting with TBK1 and modulating the TBK1/AKT signalling in rodents and monkeys.

Ke-Qiong Deng
Aibing Wang
Hongliang Li
ResearchOpen Access01 Jun 2016
Nature Communications

Volume: 7, P: 1-21
The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis

The deubiquitinase TNFAIP3 suppresses the kinase ASK1 to ameliorate nonalcoholic fatty liver disease.

Peng Zhang
Pi-Xiao Wang
Hongliang Li
Research11 Dec 2017
Nature Medicine

Volume: 24, P: 84-94
Dorsal raphe GABA-ergic neurons regulate the susceptibility to social transfer of pain in mice

Lin Ai
Yi Han
Hong-xing Zhang
Research26 Feb 2025
Acta Pharmacologica Sinica

Volume: 46, P: 1892-1904
Identification of the anti-tumor activity and mechanisms of nuciferine through a network pharmacology approach

Quan Qi
Rui Li
Shao Li
Research16 May 2016
Acta Pharmacologica Sinica

Volume: 37, P: 963-972
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

Zhu Chen, Sai-Juan Chen and colleagues report exome sequencing of acute monocytic leukemia, a subtype of acute myeloid leukemia. They identified somatic mutations of DNMT3A, which encodes a DNA methyltransferase, in 20% of cases.

Xiao-Jing Yan
Jie Xu
Sai-Juan Chen
Research13 Mar 2011
Nature Genetics

Volume: 43, P: 309-315
Evaluation of liver function and electroacupuncture efficacy of animals with alcoholic liver injury by the novel imaging methods

Dong Zhang
Xiao-jing Song
Li-mei Tang
ResearchOpen Access22 Jul 2016
Scientific Reports

Volume: 6, P: 1-9
Exercise training attenuates renovascular hypertension partly via RAS- ROS- glutamate pathway in the hypothalamic paraventricular nucleus

Yan Zhang
Xiao-Jing Yu
Yu-Ming Kang
ResearchOpen Access24 Nov 2016
Scientific Reports

Volume: 6, P: 1-10
Study of heat transfer model and buried thermocouple test of bell-type annealing furnace based on thermal equilibrium

Xiao-jing Yang
Fei-xiang Dai
Yu-ren Li
ResearchOpen Access17 Apr 2025
Scientific Reports

Volume: 15, P: 1-18
Wang et al. reply

Pi-Xiao Wang
Guang-Nian Zhao
Hongliang Li
Correspondence04 Jun 2018
Nature Medicine

Volume: 24, P: 700-701
The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis

The deubiquitinase CYLD regulates a TAK1–JNK pathway and can be targeted to ameliorate nonalcoholic steatohepatitis.

Yan-Xiao Ji
Zan Huang
Hongliang Li
Research01 Jan 2018
Nature Medicine

Volume: 24, P: 213-223
Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC

Youwen Zhou and Xue-Jun Zhang and colleagues report a genome-wide association study of generalized vitiligo, a common autoimmune disorder characterized by loss of melanocytes and depigmentation. The authors identify two independent associations within the MHC region and one new susceptibility locus on chromosome 6q27, which contains the genes RNASET2, FGFR1OP and CCR6.

Cheng Quan
Yun-Qing Ren
Xue-Jun Zhang
Research06 Jun 2010
Nature Genetics

Volume: 42, P: 614-618
Catalytic enantioselective desymmetrizing functionalization of alkyl radicals via Cu(i)/CPA cooperative catalysis

The high reactivity of open-shell alkyl radicals makes their use in asymmetric catalysis challenging. Here the authors report a catalytic enantioselective desymmetrizing reaction of alkyl radicals and diols, forming stereocentres at the reaction site and at sites remote from it.

Yong-Feng Cheng
Ji-Ren Liu
Xin-Yuan Liu
Research16 Mar 2020
Nature Catalysis

Volume: 3, P: 401-410
Exploring epistatic relationships of NO biosynthesis pathway genes in susceptibility to CHD

Yuan-chao Tu
Hu Ding
Dao-wen Wang
Research28 Jun 2010
Acta Pharmacologica Sinica

Volume: 31, P: 874-880
Targeted imaging of pulmonary fibrosis by a cyclic peptide LyP-1

Jing Li
Rui Shu
Ejuan Zhang
ResearchOpen Access08 Mar 2025
Scientific Reports

Volume: 15, P: 1-17
p63 is a p53 homologue required for limb and epidermal morphogenesis

Alea A. Mills
Binhai Zheng
Allan Bradley
Research22 Apr 1999
Nature

Volume: 398, P: 708-713
The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy

The lncRNA Chaer controls hypertrophic heart growth by binding to and interfering with the function of the epigenetic regulator PRC2.

Zhihua Wang
Xiao-Jing Zhang
Yibin Wang
Research12 Sept 2016
Nature Medicine

Volume: 22, P: 1131-1139
Inhibition of ethanol-induced toxicity by tanshinone IIA in PC12 cells

Xian-fang Meng
Xiao-jing Zou
Chun Zhang
Research01 Jun 2006
Acta Pharmacologica Sinica

Volume: 27, P: 659-664
Sodium tanshinone IIA sulfonate attenuates angiotensin II-induced collagen type I expression in cardiac fibroblasts in vitro

Le Yang
Xiao-Jing Zou
Guang-Tian Yang
ResearchOpen Access31 Jul 2009
Experimental & Molecular Medicine

Volume: 41, P: 508-516
Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in the absence of critical period plasticity

Critical period plasticity describes a developmental process whereby neural circuits are fine-tuned for specific functions. Here, the authors show that the Rett syndrome protein MeCP2 in GABAergic parvalbumin-expressing neurons is required for critical period plasticity of the visual cortex.

Ling-jie He
Nan Liu
Xiao-hui Zhang
Research09 Oct 2014
Nature Communications

Volume: 5, P: 1-15
ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia

While the role of ASLX1 in haematopoiesis and leukaemia has been heavily studied, the role of ASLX2 is unclear. Here the authors show that ASLX2 is required for normal haematopoietic stem cell self-renewal whereas Asxl2 loss promotes leukemogenesis, thus explaining the frequently observed mutations in AML patients

Jean-Baptiste Micol
Alessandro Pastore
Omar Abdel-Wahab
ResearchOpen Access18 May 2017
Nature Communications

Volume: 8, P: 1-13
Low serum osteocalcin levels are correlated with left ventricular systolic dysfunction and cardiac death in Chinese men

Xue-li Zhang
Yun Shen
Yu-qian Bao
Research10 Jul 2018
Acta Pharmacologica Sinica

Volume: 40, P: 486-491
Kv4.3 Modulates the Distribution of hERG

Xiao-Jing Zhao
Chao Zhu
Yang Li
ResearchOpen Access19 Dec 2017
Scientific Reports

Volume: 7, P: 1-10
Using polyethylene plastic bag to prevent moderate hypothermia during transport in very low birth weight infants: a randomized trial

Xiao-jing Hu
Li Wang
Guo-ying Huang
Research27 Dec 2017
Journal of Perinatology

Volume: 38, P: 332-336
Peripheral perfusion index percentiles for healthy newborns by gestational age and sex in China

Xiao-jing Hu
Jin-xiang Ding
Guo-ying Huang
ResearchOpen Access06 Mar 2020
Scientific Reports

Volume: 10, P: 1-9
Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis

Xiao-Jing Wang
David A Greenhalgh
Dennis R Roop
Research14 Jul 1998
Oncogene

Volume: 17, P: 35-45
DNA replication stress underpins the vulnerability to oxidative phosphorylation inhibition in colorectal cancer

Xiao Hong Zhao
Man Man Han
Lei Jin
ResearchOpen Access14 Jan 2025
Cell Death & Disease

Volume: 16, P: 1-12
ONTOGENY OF INDUCIBLE NITRIC OXIDE SYNTHASE IN FETAL RATS. ▴ 376

Staci M Olister
Cynthia A Voelker
Mark J.S Miller
Research01 Apr 1996
Pediatric Research

Volume: 39, P: 65
Healing of Gastric Ulcers in Rats by the Herbal Medicine, Sangre de Grado: Implications for the Developing World

Mark J S Miller
David A Clark
Manuel Sandoval
Research01 Apr 1999
Pediatric Research

Volume: 45, P: 113
IS NITRIC OXIDE-DEPENDENT UTEROPLACENTAL FUNCTION REGULATED BY iNOS, NOT cNOS? AN ELECTROCHEMICAL AND GENE EXPRESSION EVALUATION. ▴ 1395

Staci M Olister
Cynthia A Voelker
Mark J.S Miller
Research01 Apr 1996
Pediatric Research

Volume: 39, P: 235
IS PEROXYNITRITE-INDUCED APOPTOSIS INVOLVED IN INTRAUTERINE GROWTH RETARDATION? † 1429

Dana L Rivera
Maria R Pierce
Mark J.S Miller
Research01 Apr 1996
Pediatric Research

Volume: 39, P: 241
The Anti-Inflammatory Actions of the Herbal Medicine, Cat's Claw, Are Due to a Suppression of NF-κB Activation and Inhibition of Gene Expression

Mark J S Miller
Xiao-Jing Zhang
Manuel Sandoval
Research01 Apr 1999
Pediatric Research

Volume: 45, P: 114

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