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Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.

Concise and enantioenriched synthesis of chiral carbocyclic and heterocyclic spirane scaffolds is a significant objective in both academic and industrial fields. Here, the authors report the kinetic resolution of racemic spirocyclic 1,3-diketones and their analogues via catalytic asymmetric hydrogenation with the SPA-PNN ligands.

Lewis acid catalyzed tittle reaction of 1,3-dicycloalkenlidine ketones is recognized as so far the shortest and most effective 1-step method for construction of angular tricyclic scaffolds, which are extensively found in bioactive terpenoids. Here, the authors disclose the structure-reactivity relationship and a regioselectivity predicting model based on in situ IR technology, DFT calculations and machine leaning algorithms.

How do sounds affect emotions? The authors reveal that noise can suppress the rewarding-dopamine system through a non-canonical auditory pathway, leading to negative emotions like aversion and anxiety.

Metal-free catalysts offer a sustainable option for water oxidation but typically underperform compared to metal-based ones. Here, the authors report an all-organic catalyst that uses a rare oxide pathway to achieve high efficiency and long-term stability, comparable to metal-based systems.

Warm greenhouse conditions spanning the end-Permian mass extinction event are linked to increased rates of reverse weathering, according to lithium and strontium isotope records as well as geochemical modelling.

Electrocardiogram is crucial for cardiovascular disease prevention, diagnosis, and prognosis. Here, the authors present a motion-unrestricted dynamic electrocardiogram system utilizing skin-conformal, imperceptible electronics for long-term, comfortable, and accurate 12-lead monitoring.

Fabric-retentive dolostones preserve the lithium isotope composition of the seawater in which they formed and could provide a high-resolution record to complement or extend foraminiferal proxy records, as indicated by isotopic analyses of Neogene dolostones from the South China Sea.

To emulate nature biological processing, highly-integrated ultra-sensitive artificial neuromorphic system is highly desirable. Here, the authors report flexible sensor array of 1024 pixels using combination of carbon nanotubes and perovskite QDs as active matetials, achieving highly responsive device for reinforcement learning.

Here, authors show the behavioral function of two transcriptomic GABAergic neuron subtypes in the zona incerta by integrating single-nucleus sequencing, circuit mapping, and optogenetics, advancing our understanding of functional brain organization.

Here, the authors describe the mechanisms by which innate immune cells contribute to acute kidney injury, the transition from acute kidney injury to chronic kidney disease, and the progression of chronic kidney disease. They also discuss potential therapeutic strategies that target the innate immune system.

Nanospace defined by unsaturated metal coordination sites opens up the possibility of controlling and templating chemical reactivity. Here, the authors show that a Fe(III) dicarboxylate framework with triangularly arranged metal sites can direct the [2+2+2] cyclisation of nitriles, alkynes and alkenes.

Given that the human body is composed of many microbial niches, and there have been few reports on the biogeography of the microbiome, the authors analyse the intra-individual inter-organ and intra-organ microbiome of seven surface organs of deceased individuals.

Pangolins are a potential reservoir for viruses with cross-species infection potential. Here, the authors characterize a HKU4-related coronavirus isolated from pangolin and demonstrate its ability to infect human cell lines as well as its potential to infect transgenic mice expressing the human receptor DPP4.

(‒)-Morphine is an essential medicine selected by the World Health Organization, however its catalytic asymmetric syntheses have been rarely reported. Here, the authors developed an intramolecular enantioselective Michael addition leading to (‒)-morphine in a longest linear sequence of 16 steps.

A superconducting nanowire two-photon coincidence counter is demonstrated with topological optimization of delay-time series. Using a hybrid time–amplitude multiplexing strategy, all 152 potential single- and two-photon events are resolved in a 16-pixel configuration.

Biomimetic chemical logic gates transform in response to their environment but are currently focused on the microscopic properties. Here, a single crystal reset-set flip-flop circuit undergoes reversible volume shrinkage in response to ions in solution.

Mitochondria is reported to regulate ferroptosis in cancer cells. Here the authors find that mitochondria-localized VSTM2L inhibits the oligomerization of VDAC1 to protect prostate cancer cells against ferroptosis.

Here, the authors reveal that miR-27b-3p exacerbates intervertebral disc degeneration by targeting PPARG, a protective factor, suggesting that modulating miR-27b-3p and PPARG could offer novel therapeutic avenues for treatment.

Multiple pathogenic viruses are identified in a large set of pangolins, which shows that trading pangolins for scales or flesh may increase the risk of emergence of viral infections.

Smad3, a transcription factor activated by TGF-β, has been implicated in tumorigenesis. Here the authors show that Smad3 inhibits NK cell differentiation and effector function by repressing NFIL3, and that genetic or pharmacological blockade of Smad3 expands tumour-suppressive NK cells and restricts tumour growth in mice.

Suppressing wheat ASPARTIC PROTEASE 1 promotes the homeostasis of PsbO, stabilizes the photosystem complex and elongates the duration of active photosynthesis, leading to increases in the CO₂ assimilation rate, kernel weight and yield.

The diversity and spillover potential of pangolin-associated microbes are not fully understood. Here, the authors describe the distribution and spectrum of reported pangolin microbes by integrating data from multiple sources and assess their potential to emerge as human pathogens.

Nutrient intake and threat avoidance interact adaptively. Here, authors show a molecularly defined hypothalamus-to-hindbrain circuit responsible for the regulation of fear by feeding in male mice, representing a novel coordination mechanism.

Genome-wide data from 166 East Asian individuals dating to between 6000 bc and ad 1000 and from 46 present-day groups provide insights into the histories of mixture and migration of human populations in East Asia.

Xuejun Zhang and colleagues report a genome-wide association and replication studies for psoriasis, conducted in Chinese populations. They confirm previous associations in MHC and IL12B to psoriasis susceptibility, and report a new association within the LCE gene cluster at 1q21.

Yu et al. show that at least two distinct serotonergic DRN-to-BA pathways are involved in different aspects of anxiety-related behaviors via different molecular mechanisms.

Wang et al. identify a molecularly defined tetra-synaptic pathway for olfaction-evoked innate fear and anxiety in mice. These findings reveal a forebrain-to-hindbrain neural substrate for sensory-triggered fear and anxiety that bypasses the amygdala.

The central circadian circuit’s role in integrating temperature changes is not fully understood. Here, the authors demonstrate that temperature-sensitive DN1a circadian neurons in the Drosophila brain bidirectionally influence downstream circadian neurons, regulating temperature-dependent physiological activities.

Single-atom catalysts maximize metal atom efficiency and exhibit properties that can be considerably different to their nanoparticle equivalent. Now a general host–guest strategy to make various single-atom catalysts on nitrogen-doped carbon has been developed; the iridium variant electrocatalyses the formic acid oxidation reaction with high mass activity and displays high tolerance to CO poisoning.

The evolution and phylogenetic placement of gnetophytes have remained elusive. The draft genome for a gnetophyte, Gnetum montanum, is now reported. Comparative analyses identify genomic features distinguishing gnetophytes from other gymnosperms.

SARS-CoV-2-related coronaviruses are identified in Malayan pangolins (Manis javanica); these pangolin-associated coronaviruses belonged to two sub-lineages of SARS-CoV-2-related coronaviruses, including one that exhibits strong similarity in the receptor-binding ___domain to SARS-CoV-2.

Examining the in-plane spin components of the noncoplanar antiferromagnet manganese ditelluride provides spectroscopic and computational evidence of materials with a new type of plaid-like spin splitting in the antiferromagnetic ground state.

The metavirome of 31 tick species sheds light on the diversity and distinct evolution of tick-associated RNA viruses, and lays the foundation for better understanding of tick–virus interaction.

G Protein-Coupled Receptors (GPCRs) can adopt different conformations, each linked to distinct cellular outcomes. Here the authors show that compound 17b, a novel agonist of the GPCR family member FPR, robustly activates cardioprotective but not detrimental FPR signalling, showing beneficial therapeutic effect in a mouse model of cardiac infarction.

Dong, Wang et al. uncover a circuit linking Glu⁺cingulate inputs→PV⁺ neurons in the limbic thalamic reticular nucleus→intermediodorsal thalamic nucleus, and show that this cortico-intrathalamic circuit is a component of the fear circuitry and controls flight behavior in mice.