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Chemical constituents and anti-inflammatory activities of Maqian (Zanthoxylum myriacanthum var. pubescens) bark extracts

Huan-li Zhang
Xiao-qing Gan
Qi-shi Song
ResearchOpen Access06 Apr 2017
Scientific Reports

Volume: 7, P: 1-13
A single-cell transcriptional landscape of immune cells shows disease-specific changes of T cell and macrophage populations in human achalasia

Achalasia is a rare motility disorder of the esophagus resulting from abnormal immune responses, but the immunologic mechanism is unclear. Here the authors use scRNA-seq of PBMC and esophageal lower sphincter tissue and find C1QC⁺ macrophages and tissue-resident memory T cells with expanded compositions and altered transcriptional profiles in achalasia.

Zu-Qiang Liu
Hao Dai
Quan-Lin Li
ResearchOpen Access04 Aug 2023
Nature Communications

Volume: 14, P: 1-19
A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding

Insulin secretion adapts to metabolic needs, but how this happens over the short term is not clear. Here the authors show this involves upregulation of beta-cell exocytosis and requires the SUMO-protease SENP1, which responds to redox state in a zinc-dependent manner.

Haopeng Lin
Kunimasa Suzuki
Patrick E. MacDonald
ResearchOpen Access06 Jan 2024
Nature Communications

Volume: 15, P: 1-15
Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes

Single-cell multiomic and functional characterization of human pancreatic islets identifies two beta cell subtypes correlated with type 2 diabetes progression that exhibit distinct gene regulatory programs and electrophysiological phenotypes.

Gaowei Wang
Joshua Chiou
Maike Sander
Research25 May 2023
Nature Genetics

Volume: 55, P: 984-994
Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

Insulin receptor protein is present in pancreatic β-cells, but the consequences of β-cell insulin resistance are incompletely understood. Here the authors use a combination of mouse studies and mathematical modelling to show that loss of beta-cell insulin receptor affects male and female mice differently and can contribute to hyperinsulinemia in the context of glucose stimulation.

Søs Skovsø
Evgeniy Panzhinskiy
James D. Johnson
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-22
Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells

Coding variants in peptidylglycine α-amidating monooxygenase (PAM) associated with type 2 diabetes risk negatively impact overall PAM activity via defects in expression and catalytic function, resulting in reduced insulin content and altered dynamics of insulin secretion.

Soren K. Thomsen
Anne Raimondo
Anna L. Gloyn
Research27 Jul 2018
Nature Genetics

Volume: 50, P: 1122-1131
High-throughput screening campaign identifies a small molecule agonist of the relaxin family peptide receptor 4

Guang-yao Lin
Lin Lin
Ming-wei Wang
Research31 Mar 2020
Acta Pharmacologica Sinica

Volume: 41, P: 1328-1336
The spike protein of severe acute respiratory syndrome (SARS) is cleaved in virus infected Vero-E6 cells

Xiao Dong WU
Bo SHANG
Bing SUN
Research01 Oct 2004
Cell Research

Volume: 14, P: 400-406
Small antibody mimetics comprising two complementarity-determining regions and a framework region for tumor targeting

Xiao-Qing Qiu
He Wang
Shi-Tao Yue
Research05 Aug 2007
Nature Biotechnology

Volume: 25, P: 921-929
Resistin induces insulin resistance, but does not affect glucose output in rat-derived hepatocytes

Feng Liu
Tao Yang
Xi-rong Guo
Research01 Jan 2008
Acta Pharmacologica Sinica

Volume: 29, P: 98-104

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Chemical constituents and anti-inflammatory activities of Maqian (Zanthoxylum myriacanthum var. pubescens) bark extracts

A single-cell transcriptional landscape of immune cells shows disease-specific changes of T cell and macrophage populations in human achalasia

A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding

Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells

High-throughput screening campaign identifies a small molecule agonist of the relaxin family peptide receptor 4

The spike protein of severe acute respiratory syndrome (SARS) is cleaved in virus infected Vero-E6 cells

Small antibody mimetics comprising two complementarity-determining regions and a framework region for tumor targeting

Resistin induces insulin resistance, but does not affect glucose output in rat-derived hepatocytes

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