UA, a naturally-occurring compound, protects against diastolic dysfunction and cardiac remodelling in the obese mice, without altering the blood glucose level. Mechanistically, UA activated PINK1/Parkin dependent mitophagy, by which the mitochondrial defects including reduced respiratory capacity, MMP collapse and mitochondrial oxidative stress were alleviated.
- Jian-rong Huang
- Ming-hua Zhang
- Xiao-qian Wu
