Nature Search

Discrimination analysis of mass spectrometry proteomics for ovarian cancer detection

Yan-jun Hong
Xiao-dan Wang
Su Zeng
Research01 Oct 2008
Acta Pharmacologica Sinica

Volume: 29, P: 1240-1246
Single-cell analysis of peripheral blood from high-altitude pulmonary hypertension patients identifies a distinct monocyte phenotype

Single cell transcriptomic sequencing (scRNA) can identify genes that are differentially expressed in cell populations in specific diseases. Here the authors perform scRNA sequencing in a high-altitude pulmonary hypertension (HAPH) cohort and show transcriptional differences in monocyte populations.

Xin-Hua Wu
Yang-Yang He
Zhi-Cheng Jing
ResearchOpen Access31 Mar 2023
Nature Communications

Volume: 14, P: 1-14
Publisher Correction: Cannabinoid CB₁ receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior

Chen-Jie Shen
Di Zheng
Xiao-Ming Li
Amendments and Corrections30 Jan 2019
Nature Medicine

Volume: 25, P: 350
PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis

Through CRISPR–Cas9 and kinase inhibitor screening, Zhang et al. show that PKCβII phosphorylates and activates ACSL4 to enhance polyunsaturated fatty acid-containing lipid biosynthesis, thereby promoting accumulation of lipid peroxidation and ferroptosis.

Hai-Liang Zhang
Bing-Xin Hu
Xiao-Feng Zhu
Research13 Jan 2022
Nature Cell Biology

Volume: 24, P: 88-98
Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis

Elevated plasma LDL cholesterol levels increase the risk of atherosclerotic cardiovascular disease. Here, the authors show that inhibition of MT1-MMP reduces plasma LDL cholesterol levels and the risk of atherosclerosis, indicating the potential of MT1-MMP inhibition as a lipid-lowering therapy.

Adekunle Alabi
Xiao-Dan Xia
Da-Wei Zhang
ResearchOpen Access25 Mar 2021
Nature Communications

Volume: 12, P: 1-17
N⁶-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

Liver metastasis of colorectal cancer leads to poor prognosis. Here the authors report that an N⁶-methyladenosine modified circular RNA is upregulated in colorectal cancer and promotes liver metastasis by enhancing the stability of HMGA2 mRNA.

Ri-Xin Chen
Xin Chen
Dan Xie
ResearchOpen Access16 Oct 2019
Nature Communications

Volume: 10, P: 1-15
FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer

B7H3 is a transmembrane B7 family checkpoint molecule present on many cancer cells. Here the authors show that FUT8 mediates fucosylation of B7H3 to limit the immune response to triple-negative breast cancer as a potentially targeted mechanism of non-responsiveness to current checkpoint therapies.

Yun Huang
Hai-Liang Zhang
Rong Deng
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-18
An optimal posttreatment surveillance strategy for cancer survivors based on an individualized risk-based approach

Monitoring patients for the recurrence of cancer can be costly and it is important to devise the optimum strategy for a given cancer and population. Here, the authors use nasopharyngeal cancer as a model and show using patient data an optimal follow-up schedule to detect recurrence of the cancer.

Guan-Qun Zhou
Chen-Fei Wu
Ying Sun
ResearchOpen Access03 Aug 2020
Nature Communications

Volume: 11, P: 1-9
Distinct serotonergic pathways to the amygdala underlie separate behavioral features of anxiety

Yu et al. show that at least two distinct serotonergic DRN-to-BA pathways are involved in different aspects of anxiety-related behaviors via different molecular mechanisms.

Xiao-Dan Yu
Yi Zhu
Xiao-Ming Li
Research29 Nov 2022
Nature Neuroscience

Volume: 25, P: 1651-1663
Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation

T cell mediated therapies have proven largely unsuccessful in triple-negative breast cancer (TNBC). Here, the authors show that autophagy is reduced in TNBC, which results in an increase in Tenascin C and reduced activation of tumour infiltrating lymphocytes.

Zhi-Ling Li
Hai-Liang Zhang
Rong Deng
ResearchOpen Access30 Jul 2020
Nature Communications

Volume: 11, P: 1-19
A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2

Zhe-Rui Zhang
Ya-Nan Zhang
Bo Zhang
ResearchOpen Access03 Oct 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-3
5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs

Chen et al. provide an m⁵C landscape in bladder cancer and show m⁵C enrichment at oncogene mRNAs that promotes tumour progression. They identify YBX1 as the m⁵C ‘reader’ that recruits ELAVL1 to stabilize mRNAs.

Xin Chen
Ang Li
Yun-Gui Yang
Research29 Jul 2019
Nature Cell Biology

Volume: 21, P: 978-990
Cannabinoid CB₁ receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior

Activating cannabinoid receptors in a newly identified neural circuit ameliorates depressive-like behaviors in mice.

Chen-Jie Shen
Di Zheng
Xiao-Ming Li
Research14 Jan 2019
Nature Medicine

Volume: 25, P: 337-349
Association between SLCO1B1 T521C polymorphism and risk of statin-induced myopathy: a meta-analysis

Qian Xiang
Shu-qing Chen
Yi-min Cui
Research24 Sept 2018
The Pharmacogenomics Journal

Volume: 18, P: 721-729
Comparative analysis of cognitive impairment prevalence and its etiological subtypes in a rural area of northern China between 2010 and 2015

Hui Lu
Xiao-Dan Wang
Yong Ji
ResearchOpen Access29 Jan 2019
Scientific Reports

Volume: 9, P: 1-7
CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation

Neuroblastoma cell differentiation is regulated by Id proteins. Here, the authors show that CaMKII-mediated phosphorylation of Beclin 1 can activate K63-linked ubiquitination and autophagic degradation of Id proteins uncovering a role for autophagy in cell differentiation.

Xuan Li
Xiao-Qi Wu
Xiao-Feng Zhu
ResearchOpen Access27 Oct 2017
Nature Communications

Volume: 8, P: 1-16
Different pathogenesis of SARS-CoV-2 Omicron variant in wild-type laboratory mice and hamsters

Ya-Nan Zhang
Zhe-Rui Zhang
Bo Zhang
ResearchOpen Access25 Feb 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-3
An alphavirus replicon particle delivering prefusion-stabilized spike protein provides potent immunoprotection against SARS-CoV-2 Omicron variant

Hong-Qing Zhang
Ya-Nan Zhang
Han-Qing Ye
ResearchOpen Access14 Dec 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-4
Inhibition of mitochondrial OMA1 ameliorates osteosarcoma tumorigenesis

Lingyan Chen
Dejian Chen
Xiao-dan Xia
ResearchOpen Access01 Nov 2024
Cell Death & Disease

Volume: 15, P: 1-16
Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis

Yan Yu
Xiao-Dan Peng
Xiao-Feng Zhu
ResearchOpen Access01 Dec 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-15
Lactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model

Yang Fu
Yong-Song Chen
Wen-Ce Wang
ResearchOpen Access20 Mar 2024
npj Biofilms and Microbiomes

Volume: 10, P: 1-22
Polydatin protects the respiratory system from PM_2.5 exposure

Xiao-Dan Yan
Qi-Ming Wang
Jian-Dong Jiang
ResearchOpen Access09 Jan 2017
Scientific Reports

Volume: 7, P: 1-11
Intranasal delivery of replicating mRNA encoding neutralizing antibody against SARS-CoV-2 infection in mice

Jia-Qi Li
Zhe-Rui Zhang
Han-Qing Ye
ResearchOpen Access25 Oct 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-8
DHX9/DNA-tandem repeat-dependent downregulation of ciRNA-Fmn1 in the dorsal horn is required for neuropathic pain

Xiao-dan Liu
Tong Jin
Zhi-qiang Pan
Research24 Apr 2023
Acta Pharmacologica Sinica

Volume: 44, P: 1748-1767
A mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles

Ya-Nan Zhang
Xiao-Dan Li
Bo Zhang
CorrespondenceOpen Access25 Aug 2020
Cell Research

Volume: 30, P: 1046-1048
Epidemical and etiological study on hand, foot and mouth disease following EV-A71 vaccination in Xiangyang, China

Xiao-Dan Meng
Yeqing Tong
Shuo Shen
ResearchOpen Access01 Dec 2020
Scientific Reports

Volume: 10, P: 1-11
AKT-mediated regulation of chromatin ubiquitylation and tumorigenesis through Mel18 phosphorylation

Jia Mai
Xiao-Dan Peng
Rong Deng
Research04 Mar 2021
Oncogene

Volume: 40, P: 2422-2436
Role of autophagy in modulating post-maturation aging of mouse oocytes

Fei-Hu Lin
Wei-Ling Zhang
Jing-He Tan
ResearchOpen Access22 Feb 2018
Cell Death & Disease

Volume: 9, P: 1-12
Increased morbidity of obese mice infected with mouse-adapted SARS-CoV-2

Ya-Nan Zhang
Zhe-Rui Zhang
Bo Zhang
CorrespondenceOpen Access25 Aug 2021
Cell Discovery

Volume: 7, P: 1-4
Exosome-packaged miR-1246 contributes to bystander DNA damage by targeting LIG4

Li-Jun Mo
Man Song
Ping-Kun Zhou
ResearchOpen Access24 Jul 2018
British Journal of Cancer

Volume: 119, P: 492-502
Transcriptome analysis of genes associated with autolysis of Coprinus comatus

Hong-Bo Guo
Zhi-Fei Zhang
Xiao-Dan Yu
ResearchOpen Access15 Feb 2022
Scientific Reports

Volume: 12, P: 1-13
Up-regulation of miR-98 and unraveling regulatory mechanisms in gestational diabetes mellitus

Jing-Li Cao
Lu Zhang
Hong-Fei Xia
ResearchOpen Access30 Aug 2016
Scientific Reports

Volume: 6, P: 1-13
Transplantation of umbilical cord-derived mesenchymal stem cells promotes the recovery of thin endometrium in rats

Lu Zhang
Ying Li
Xu Ma
ResearchOpen Access10 Jan 2022
Scientific Reports

Volume: 12, P: 1-13
De novo mutations of TUBA3D are associated with keratoconus

Xiao-dan Hao
Peng Chen
Hua Gao
ResearchOpen Access19 Oct 2017
Scientific Reports

Volume: 7, P: 1-10
The roles of Toll-like receptor 4 in the pathogenesis of pathogen-associated biliary fibrosis caused by Clonorchis sinensis

Chao Yan
Bo Li
Kui-Yang Zheng
ResearchOpen Access20 Jun 2017
Scientific Reports

Volume: 7, P: 1-9
Physical exercise rescues cocaine-evoked synaptic deficits in motor cortex

Tong Cheng
Xiao-Dan Huang
Li Zhang
Research22 Oct 2021
Molecular Psychiatry

Volume: 26, P: 6187-6197

Search

Discrimination analysis of mass spectrometry proteomics for ovarian cancer detection

Single-cell analysis of peripheral blood from high-altitude pulmonary hypertension patients identifies a distinct monocyte phenotype

Publisher Correction: Cannabinoid CB₁ receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior

PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis

Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis

N⁶-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer

An optimal posttreatment surveillance strategy for cancer survivors based on an individualized risk-based approach

Distinct serotonergic pathways to the amygdala underlie separate behavioral features of anxiety

Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation

A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2

5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs

Cannabinoid CB₁ receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior

Association between SLCO1B1 T521C polymorphism and risk of statin-induced myopathy: a meta-analysis

Comparative analysis of cognitive impairment prevalence and its etiological subtypes in a rural area of northern China between 2010 and 2015

CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation

Different pathogenesis of SARS-CoV-2 Omicron variant in wild-type laboratory mice and hamsters

An alphavirus replicon particle delivering prefusion-stabilized spike protein provides potent immunoprotection against SARS-CoV-2 Omicron variant

Inhibition of mitochondrial OMA1 ameliorates osteosarcoma tumorigenesis

Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis

Lactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model

Polydatin protects the respiratory system from PM_2.5 exposure

Intranasal delivery of replicating mRNA encoding neutralizing antibody against SARS-CoV-2 infection in mice

DHX9/DNA-tandem repeat-dependent downregulation of ciRNA-Fmn1 in the dorsal horn is required for neuropathic pain

A mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles

Epidemical and etiological study on hand, foot and mouth disease following EV-A71 vaccination in Xiangyang, China

AKT-mediated regulation of chromatin ubiquitylation and tumorigenesis through Mel18 phosphorylation

Role of autophagy in modulating post-maturation aging of mouse oocytes

Increased morbidity of obese mice infected with mouse-adapted SARS-CoV-2

Exosome-packaged miR-1246 contributes to bystander DNA damage by targeting LIG4

Transcriptome analysis of genes associated with autolysis of Coprinus comatus

Up-regulation of miR-98 and unraveling regulatory mechanisms in gestational diabetes mellitus

Transplantation of umbilical cord-derived mesenchymal stem cells promotes the recovery of thin endometrium in rats

De novo mutations of TUBA3D are associated with keratoconus

The roles of Toll-like receptor 4 in the pathogenesis of pathogen-associated biliary fibrosis caused by Clonorchis sinensis

Physical exercise rescues cocaine-evoked synaptic deficits in motor cortex

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