Induced pluripotent stem (iPS) cells were first created by forced expression of four transcription factors in mouse fibroblasts, a technique that has since been widely used to generate embryonic stem (ES)-cell-like pluripotent cells from a variety of cell types in other species. The generation of several iPS cell lines in mice that are capable of generating viable, fertile live-born progeny by tetraploid complementation — a technique where chimaeric mice are generated using injected pluripotent cells — is now reported.
- Xiao-yang Zhao
- Wei Li
- Qi Zhou
