Nature Search

Rapid assembly of enantioenriched α-arylated ketones via Ni-catalyzed asymmetric cross-hydrocarbonylation enabled by alkene sorting

Enantioenriched α-arylated dialkyl ketones with acidic proton are ubiquitous subunits in organic molecules and serve as synthetic precursors for other value-added chiral blocks. Here, the authors report a synthetic strategy of enantioenriched α-arylated dialkyl ketones enabled by nickel-catalyzed iterative cross-hydrocarbonylation of two alkenes.

Yi-Ming Du
Xiao-Yi Chen
Wei Shu
ResearchOpen Access05 May 2025
Nature Communications

Volume: 16, P: 1-9
Engineering multi-specific nano-antibodies for cancer immunotherapy

A versatile nano-adaptor is used to construct multi-specific nano-antibodies for treatment of tumours in mice.

Ya-Nan Fan
Long Zhu
Jun Wang
Research26 Jun 2025
Nature Biomedical Engineering

P: 1-17
Enantioselective alkyl–alkyl coupling by Ni-catalysed asymmetric cross-hydrodimerization of alkenes

Methods for asymmetric alkyl–alkyl bond formation between sp³-hybridized carbon atoms, C(sp³)–C(sp³), are limited yet highly desirable. Now an approach for asymmetric alkyl–alkyl bond formation by Ni-catalysed cross-coupling between alkenes has been developed to construct tertiary stereogenic carbon centres with head-to-tail regioselectivity and excellent chemo- and enantioselectivity.

Peng-Fei Yang
Han-Tong Zhao
Wei Shu
Research11 Jul 2024
Nature Synthesis

Volume: 3, P: 1360-1368
Organophotocatalysed synthesis of 2-piperidinones in one step via [1 + 2 + 3] strategy

The synthesis of 2-piperidinone derivatives remains challenging. Here, the authors develop an organophotocatalysed [1 + 2 + 3] strategy to enable the one-step access to diverse 2-piperidinones from ammonium salts, alkenes, and unsaturated carbonyl compounds.

Yi-Dan Du
Shan Wang
Wei Shu
ResearchOpen Access02 Sept 2023
Nature Communications

Volume: 14, P: 1-9
Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease

In vivo reprogramming of reactive glia using transfection of a single transcription factor has been described before by these authors and applied to models of neurodegeneration. Here the authors use this procedure in the R6/2 mouse model of Huntington’s disease, targeting astrocytes in the striatum, converting them to GABAergic neurons.

Zheng Wu
Matthew Parry
Gong Chen
ResearchOpen Access27 Feb 2020
Nature Communications

Volume: 11, P: 1-18
Direct synthesis of hydrazine by efficient electrochemical ruthenium-catalysed ammonia oxidation

The electrochemical synthesis of hydrazine is a very attractive yet challenging process. Now, the direct electrochemical oxidation of ammonia to hydrazine on a Ru complex catalyst, involving a bimolecular N‒N coupling mechanism, is reported.

Guo Chen
Piao He
Xiao-Yi Yi
Research21 Sept 2023
Nature Catalysis

Volume: 6, P: 949-958
High-throughput real-time assay based on molecular beacons for HIV-1 integrase 3′-processing reaction

Hong-qiu He
Xiao-hui Ma
Shao-hui Cheng
Research01 Jun 2007
Acta Pharmacologica Sinica

Volume: 28, P: 811-817
The immunoglobulin D Fc receptor expressed on fibroblast-like synoviocytes from patients with rheumatoid arthritis contributes to the cell activation

Yu-jing Wu
Wen-sheng Chen
Wei Wei
Research03 Aug 2017
Acta Pharmacologica Sinica

Volume: 38, P: 1466-1474
Regional ambient temperature is associated with human personality

Personality traits differ across geographical regions, suggesting a role for environmental factors. Wei, Lu, and colleagues show an association between regional ambient temperature and personality in two large studies conducted in China and the United States.

Wenqi Wei
Jackson G. Lu
Lei Wang
Research27 Nov 2017
Nature Human Behaviour

Volume: 1, P: 890-895
Delta radiomics analysis for prediction of intermediary- and high-risk factors for patients with locally advanced cervical cancer receiving neoadjuvant therapy

Rong-Rong Wu
Yi-Min Zhou
Wen-Juan Chen
ResearchOpen Access08 Nov 2023
Scientific Reports

Volume: 13, P: 1-8
Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor

Li Hua Wang
Xiao Yi Yang
William L Farrar
Research14 Dec 2003
Nature Medicine

Volume: 10, P: 40-47
Regulation of angiotensin-(1–7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure

Wen-na Zong
Xiao-hui Yang
Xin-zheng Lu
Research03 Oct 2011
Acta Pharmacologica Sinica

Volume: 32, P: 1345-1350
Interleukin-1 receptor antagonist intervenes in signaling between different types of synoviocytes in rats with adjuvant arthritis

Yong-qiu Zheng
Wei Wei
Yuan Wang
Research01 Jan 2006
Acta Pharmacologica Sinica

Volume: 27, P: 111-118
Mutation analysis of a large Chinese pedigree with congenital preaxial polydactyly

Hui Li
Cheng-Ye Wang
Ya-Ping Zhang
Research10 Dec 2008
European Journal of Human Genetics

Volume: 17, P: 604-610
Circulating T lymphocyte subsets, cytokines, and immune checkpoint inhibitors in patients with bipolar II or major depression: a preliminary study

Wei Wu
Ya-li Zheng
Shao-hua Hu
ResearchOpen Access11 Jan 2017
Scientific Reports

Volume: 7, P: 1-7
In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine

Na Yang
Run-bin Sun
Guang-ji Wang
Research02 Jan 2017
Acta Pharmacologica Sinica

Volume: 38, P: 351-361
Identifying a non-conserved site for achieving allosteric covalent inhibition of CECR2

Cai-ling Tang
Yuan-qing Li
Hong Ding
Research20 Jan 2025
Acta Pharmacologica Sinica

Volume: 46, P: 1476-1491
SMRT sequencing revealed to be an effective method for ADTKD-MUC1 diagnosis through follow-up analysis of a Chinese family

Guo-qin Wang
Hong-liang Rui
Hong Cheng
ResearchOpen Access25 May 2020
Scientific Reports

Volume: 10, P: 1-12
Quinpirole ameliorates nigral dopaminergic neuron damage in Parkinson’s disease mouse model through activating GHS-R1a/D₂R heterodimers

Ting-ting Tang
Ming-xia Bi
Hong Jiang
ResearchOpen Access10 Mar 2023
Acta Pharmacologica Sinica

Volume: 44, P: 1564-1575
Altered resting-state neural activity and changes following a craving behavioral intervention for Internet gaming disorder

Jin-Tao Zhang
Yuan-Wei Yao
Xiao-Yi Fang
ResearchOpen Access06 Jul 2016
Scientific Reports

Volume: 6, P: 1-8
An integrated machine learning framework for a discriminative analysis of schizophrenia using multi-biological data

Peng-fei Ke
Dong-sheng Xiong
Kai Wu
ResearchOpen Access19 Jul 2021
Scientific Reports

Volume: 11, P: 1-11
Effect of nicotine on Staphylococcus aureus biofilm formation and virulence factors

Le Shi
Yang Wu
Ke-Qing Zhao
ResearchOpen Access27 Dec 2019
Scientific Reports

Volume: 9, P: 1-13
Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response

Ting-Yu Chen
Bu-Miin Huang
Chia-Yih Wang
ResearchOpen Access18 Jan 2021
Cell Death & Differentiation

Volume: 28, P: 1865-1879
The Antihelminthic Niclosamide Inhibits Cancer Stemness, Extracellular Matrix Remodeling, and Metastasis through Dysregulation of the Nuclear β-catenin/c-Myc axis in OSCC

Lin-Hong Wang
Mei Xu
Fan Yang
ResearchOpen Access24 Aug 2018
Scientific Reports

Volume: 8, P: 1-13
The transcription factor Zfp90 regulates the self-renewal and differentiation of hematopoietic stem cells

Ting Liu
Wei-xia Kong
Hu Chen
ResearchOpen Access07 Jun 2018
Cell Death & Disease

Volume: 9, P: 1-12
Characteristics of pulsed runoff-erosion events under typical rainstorms in a small watershed on the Loess Plateau of China

Lei Wu
Jun Jiang
Xiao-yi Ma
ResearchOpen Access27 Feb 2018
Scientific Reports

Volume: 8, P: 1-12
The potential role of hydrogen sulfide in cancer cell apoptosis

Wei Gao
Ya-Fang Liu
Dong-Dong Wu
ReviewsOpen Access06 Mar 2024
Cell Death Discovery

Volume: 10, P: 1-15
Heterocyclyl tetracyclines. 2. 7-Methoxy-8-pyrrolidinyltetracyclines: discovery of TP-2758, a potent, orally efficacious antimicrobial against Gram-negative pathogens

Cuixiang Sun
Yonghong Deng
Xiao-Yi Xiao
Research26 Jul 2017
The Journal of Antibiotics

Volume: 71, P: 287-297

Search

Rapid assembly of enantioenriched α-arylated ketones via Ni-catalyzed asymmetric cross-hydrocarbonylation enabled by alkene sorting

Engineering multi-specific nano-antibodies for cancer immunotherapy

Enantioselective alkyl–alkyl coupling by Ni-catalysed asymmetric cross-hydrodimerization of alkenes

Organophotocatalysed synthesis of 2-piperidinones in one step via [1 + 2 + 3] strategy

Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease

Direct synthesis of hydrazine by efficient electrochemical ruthenium-catalysed ammonia oxidation

High-throughput real-time assay based on molecular beacons for HIV-1 integrase 3′-processing reaction

The immunoglobulin D Fc receptor expressed on fibroblast-like synoviocytes from patients with rheumatoid arthritis contributes to the cell activation

Regional ambient temperature is associated with human personality

Delta radiomics analysis for prediction of intermediary- and high-risk factors for patients with locally advanced cervical cancer receiving neoadjuvant therapy

Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor

Regulation of angiotensin-(1–7) and angiotensin II type 1 receptor by telmisartan and losartan in adriamycin-induced rat heart failure

Interleukin-1 receptor antagonist intervenes in signaling between different types of synoviocytes in rats with adjuvant arthritis

Mutation analysis of a large Chinese pedigree with congenital preaxial polydactyly

Circulating T lymphocyte subsets, cytokines, and immune checkpoint inhibitors in patients with bipolar II or major depression: a preliminary study

In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine

Identifying a non-conserved site for achieving allosteric covalent inhibition of CECR2

SMRT sequencing revealed to be an effective method for ADTKD-MUC1 diagnosis through follow-up analysis of a Chinese family

Quinpirole ameliorates nigral dopaminergic neuron damage in Parkinson’s disease mouse model through activating GHS-R1a/D₂R heterodimers

Altered resting-state neural activity and changes following a craving behavioral intervention for Internet gaming disorder

An integrated machine learning framework for a discriminative analysis of schizophrenia using multi-biological data

Effect of nicotine on Staphylococcus aureus biofilm formation and virulence factors

Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response

The Antihelminthic Niclosamide Inhibits Cancer Stemness, Extracellular Matrix Remodeling, and Metastasis through Dysregulation of the Nuclear β-catenin/c-Myc axis in OSCC

The transcription factor Zfp90 regulates the self-renewal and differentiation of hematopoietic stem cells

Characteristics of pulsed runoff-erosion events under typical rainstorms in a small watershed on the Loess Plateau of China

The potential role of hydrogen sulfide in cancer cell apoptosis

Heterocyclyl tetracyclines. 2. 7-Methoxy-8-pyrrolidinyltetracyclines: discovery of TP-2758, a potent, orally efficacious antimicrobial against Gram-negative pathogens

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