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Realization of a gyromagnetic double-zero-index metamaterial results in unconventional optical and topological properties, suitable to be used for the generation of light pulses shaped as a vortex both in time and space.

Lai et al. present a spatially resolved atlas of human atherosclerotic plaques, revealing cellular heterogeneity and identifying lymphoid structures and their potential functions and implications.

Transient glaciation simulation during the last 3 Ma highlighted that extensive valley glaciations over High Mountain Asia began from 1.5 ~ 0.9 Ma, but the exact timing diverges across monsoonal- and westerly-influenced regions.

The prevalence of mutations that can predispose to pancreatic adenocarcinoma (PDAC) remains unclear, especially in underrepresented populations. Here, the authors create a germline mutation map of 1,123 Chinese PDAC patients and compare them to cohorts from other populations, finding CFTR as a potential driver.

SFTS is an emerging tick-borne disease with high mortality rates caused by the SFTS virus. Here, the authors identify LRP1 as an entry factor for SFTSV, show that SFTSV glycoprotein Gn interacts with LRP1 and that blocking LRP1 reduces viral infection and improves survival in lethal mouse models.

Oligomers are among the various chemical contaminants that can derive from the breakdown of microplastics and that are challenging to detect. A purposely designed platform allows detection of a large number of oligomers, providing an important step towards their risk assessment.

Diffuse intrinsic pontine glioma (DIPG) is driven by H3K27M oncohistones, but the exact related mechanisms are poorly understood. Here, the authors identify an H3.3K27M oncohistone-driven CREB5/ID1 axis that promotes transcriptional changes and progression in DIPG, which could represent a potential therapeutic target.

In-sensor computing can improve the efficiency of target detection and signal processing. Here, the authors report an in-sensor computing camera based on multi-dimensional reconfigurable array detector, which can achieve multiple visual functions with high photon utilization.

A study reports data from the first phase of the Chinese Pangenome Consortium including 116 de novo assemblies from 58 core samples representing 36 minority Chinese ethnic groups.

Low-toxicity ZnSe–ZnS core–shell quantum dots show tunable and stable blue lasing in solution.

Although accumulating evidence indicates that epithelial cell cycle G2/M arrest is involved in kidney fibrosis, the underlying mechanism remains unclear. Here, the authors show that HDAC9 is upregulated in the fibrotic kidney and promotes epithelial cell cycle arrest in G2/M by regulating STAT1.

A one-step fluorescence assay relying on suboptimal protospacer adjacent motifs for Cas12a detects SARS-CoV-2 RNA in nasopharyngeal samples in less than 20 minutes with a sensitivity comparable to that of RT–qPCR.

Tong et al. engineered Cas12b and redesigned the target sequence of Cas13a to minimize the interference caused by the cleavage mediated by Cas effectors in one-pot testing, which enables sensitive nucleic acid detection in a simple way at room temperature.

Cancer-associated fibroblasts (CAFs) have been implicated in lung cancer chemo-resistance. Here the authors show that a zinc-transporter positive CAF subset is enriched in lung cancer models after chemotherapy and actively transfers zinc to cancer cells, promoting ABCB1-mediated chemo-resistance.

Analysis of chronic kidney disease transcriptomics data and an experiment focused on a male mouse model of kidney fibrosis shed light on the role of ADAMS18 in TGF-β-induced fibrosis

The authors uncover the relevance of Piezo1 mechanosensors expressed in the stomach for sensing gastric distention and regulating feeding behaviour.

A CRISPR–Cas9 screen identifies genes that modulate long interspersed nuclear element-1 (LINE-1) expression in human cells. LINE-1 5′ UTRs have enhancer features and can activate long-range gene expression, including during zygotic genome activation.

Efficient metabolic regulation is key for parasite growth. Here, the authors report that Toxoplasma alters its AMPK phosphorylation during the lytic cycle, which reprograms parasite’s metabolism to ensure metabolic needs at different stages are met.

Plasma cells are terminally differentiated B cells that are specialized for antibody secretion. Authors show here that genomic deletion of the p38α mitogen activated protein kinase specifically in the B cell lineage leads to diminished plasma cell differentiation via impairment of a transcriptional regulatory program by BLIMP1.

Realizing complex functions in artificial visual systems is challenging. Here, the authors report a human visual pathway-replicated hardware with a split floating gate crossbar arrays and related peripheral circuits, achieving colour-blindness processing, shape recognition, and self-driven motion tracking.

In poplar, a quantitative genetic screen identifies a G-type lectin receptor-like kinase that mediates ectomycorrhizal symbiosis with Laccaria bicolor. Expression of the kinase in non-host Arabidopsis makes mycorrhizal colonization possible.

The practical device application of transition-metal dichalcogenide superconductors (TMDSCs) is limited by their environmental instability. Here, the authors report a generic, non-destructive, and scalable strategy to fabricate TMDSC nanocircuits via the topotactic conversion of prepatterned metallic precursors.

EGFR is a well-known oncogene; however, the mechanisms regulating its expression are still unclear. Here, analysing genome-wide chromatin associations, the authors show that in breast cancer cells ZNF516 represses EGFR transcription through the interaction with the CtBP/LSD1/CoREST complex.

Wang and colleagues report a two-dimensional root carbon trait space coupled with the root economics space, offering molecular insights into the great diversity of root form and function.

Understanding water oxidation on Mn-based catalysts remains a long-standing challenge. Here, the authors use homologous KMnPO₄ and KMnPO₄•H₂O as model catalyst to show that Mn(V)=O is responsible for O−O bond formation and its concentration determines the intrinsic activity.

Hippo signaling leads to the phosphorylation of the key transcriptional effector, Yap/Yki, although how Yap/Yki stability is regulated has remained unclear. Here, Sun et al. identify HAUSP/Usp7 as a conserved and clinically relevant regulator of the Hippo pathway that increases Yap/Yki stability.

Congenital vertebral malformation has a complex genetic architecture that isn’t fully understood. Here, the authors explore the genetic architecture of congenital vertebral malformation through case-control rare variant genetic analyses and embryonic transcriptome analyses of the developing spine.

Ambiguity in human-oriented traffic laws poses a significant challenge to the regulation of self-driving vehicles. Here, the authors present a trigger-based hierarchical online compliance monitor for self-assessment of self-driving vehicles using ambiguous compliance threshold selection principles.

Wang et al. constructed an index reflecting the quality of global gastric cancer care. They identified an association between robust radiotherapy access, improved gastric cancer QCI, and reduced gender-based disparities, and spotlighted the importance of fortifying radiotherapy infrastructure within areas and populations of greatest need.

Quantum dot LED brightness can be enhanced at low driving voltage using a monolayer of large quantum dots to reduce the packing number in the emitting layer and minimize heat generation.

Using an integrated analysis on three independent large human datasets, Wang et al. map macroscale dysconnectivity in schizophrenia onto layer- and cell-type-specific microscale alterations. The authors identify different alterations of corticocortical and corticostriatal connectivity in schizophrenia and their relationship to different symptom dimensions and functional domains.

Establishment of multiple split selectable marker systems that utilize inteins to enable selection of transgenic plants stably transformed with two T-DNAs via Agrobacterium-mediated transformation.