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Oxygen enhances antiviral innate immunity through maintenance of EGLN1-catalyzed proline hydroxylation of IRF3

Oxygen is an essential requirement for aerobic organisms. Here the authors explore the role of oxygen in the antiviral innate response in multiple models of infection and suggest oxygen enhances the antiviral innate response via EGLN1 hydroxylation of IRF3.

Xing Liu
Jinhua Tang
Wuhan Xiao
ResearchOpen Access26 Apr 2024
Nature Communications

Volume: 15, P: 1-21
OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1α during hypoxia adaptation

Xing Liu
Hongyan Deng
Wuhan Xiao
ResearchOpen Access22 Jun 2022
Cell Death & Disease

Volume: 13, P: 1-12

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Oxygen enhances antiviral innate immunity through maintenance of EGLN1-catalyzed proline hydroxylation of IRF3

OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1α during hypoxia adaptation

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