Nature Search

Multi-omic analysis of gallbladder cancer identifies distinct tumor microenvironments associated with disease progression

Single-cell RNA sequencing, whole-exome sequencing and spatial transcriptome sequencing of gallbladder adenocarcinomas from 75 patients stratifies the disease into groups with distinct clinical outcomes.

Tao Zhou
Yanhong Wu
Lei Chen
Research26 Jun 2025
Nature Genetics

P: 1-15
PRL3-zumab as an anti-angiogenic therapy in neovascular eye diseases

Neovascular eye diseases cause blindness, but underlying drivers are unclear. Here, the authors show that PRL3 promotes pathological angiogenesis, and that targeting PRL3 with an antibody therapy could offer a new treatment for ocular neovascularization.

Koon Hwee Ang
Min Thura
Qi Zeng
ResearchOpen Access23 May 2025
Nature Communications

Volume: 16, P: 1-15
Phospholipid biosynthesis modulates nucleotide metabolism and reductive capacity

Zhu et al. found that cytidine triphosphate usage in the Kennedy pathway for phospholipid synthesis influences nucleotide metabolism and redox balance. Phospholipid synthesis acts as an integrative defense mechanism to sense and combat oxidative stress.

Yibing Zhu
Xiaomeng Tong
Cunqi Ye
Research26 Jul 2024
Nature Chemical Biology

Volume: 21, P: 35-46
Macrophage lineage cells-derived migrasomes activate complement-dependent blood-brain barrier damage in cerebral amyloid angiopathy mouse model

Migrasomes are recently discovered extracellular vesicles that are produced during cellular migration. Here, the authors show that macrophage-derived migrasomes are implicated in the progression of cerebral amyloid angiopathy (CAA) through increased complement signaling using skin biopsies from CAA patients and CAA mouse models.

Mengyan Hu
Tiemei Li
Wei Cai
ResearchOpen Access04 Jul 2023
Nature Communications

Volume: 14, P: 1-19
Structural snapshots of human pre-60S ribosomal particles before and after nuclear export

Ribosome biogenesis in eukaryotes is a complex process that involves more than 200 protein factors. Here the authors present a structural analysis of a collection of human pre-60S structures sampled through a nuclear export adaptor NMD3, representing structural snapshots of pre-60S particles immediately before and after passing through nuclear pore complex.

Xiaomeng Liang
Mei-Qing Zuo
Ning Gao
ResearchOpen Access15 Jul 2020
Nature Communications

Volume: 11, P: 1-14
Prompt-to-afterglow transition of optical emission in a long gamma-ray burst consistent with a fireball

Rare early optical observations that captured the prompt-to-afterglow emission of GRB 201223A demonstrate that it behaved according to the fireball model of gamma-ray bursts.

Liping Xin
Xuhui Han
Jianyan Wei
Research10 Apr 2023
Nature Astronomy

Volume: 7, P: 724-730
An atlas of gene regulatory elements in adult mouse cerebrum

A comprehensive analysis of gene regulatory elements in 160 distinct cell types from the mouse cerebrum.

Yang Eric Li
Sebastian Preissl
Bing Ren
ResearchOpen Access06 Oct 2021
Nature

Volume: 598, P: 129-136
Electrochemically induced nickel catalysis for oxygenation reactions with water

As Ni(ii) complexes are generally considered inert toward O₂, their utilization for catalytic oxygenation reactions is extremely rare. Here, the authors introduce an electrocatalytic method for the oxidation of sulfides based on bipyridine complexes of simple Ni(ii) salts using water as the oxygen source.

Yujie Liang
Shi-Hui Shi
Ning Jiao
Research11 Jan 2021
Nature Catalysis

Volume: 4, P: 116-123
A rare deep intronic mutation of PKHD1 gene, c.8798-459 C > A, causes autosomal recessive polycystic kidney disease by pseudoexon activation

Jing Chen
Na Ma
Juan Du
Research07 Jan 2019
Journal of Human Genetics

Volume: 64, P: 207-214
Evolution of coastal forests based on a full set of mangrove genomes

Analysis of 48 newly generated genomes, including 32 mangrove species, sheds light on patterns of speciation and extinction of these woody, coastal plants.

Ziwen He
Xiao Feng
Suhua Shi
Research28 Apr 2022
Nature Ecology & Evolution

Volume: 6, P: 738-749
An improved Gaussian process for filling the missing data in GNSS position time series considering the influence of adjacent stations

Xiaomeng Qiu
Fengwei Wang
Shijian Zhou
ResearchOpen Access20 Aug 2024
Scientific Reports

Volume: 14, P: 1-13
Towards precision medicine based on a continuous deep learning optimization and ensemble approach

Jian Li
Linyuan Jin
Jieke Liao
ResearchOpen Access03 Feb 2023
npj Digital Medicine

Volume: 6, P: 1-11
The neglected role of micronutrients in predicting soil microbial structure

Ziheng Peng
Chunling Liang
Shuo Jiao
ResearchOpen Access27 Dec 2022
npj Biofilms and Microbiomes

Volume: 8, P: 1-10
The Asian arowana (Scleropages formosus) genome provides new insights into the evolution of an early lineage of teleosts

Chao Bian
Yinchang Hu
Qiong Shi
ResearchOpen Access19 Apr 2016
Scientific Reports

Volume: 6, P: 1-17
A longitudinal resource for population neuroscience of school-age children and adolescents in China

Xue-Ru Fan
Yin-Shan Wang
Xi-Nian Zuo
ResearchOpen Access21 Aug 2023
Scientific Data

Volume: 10, P: 1-24

Search

Multi-omic analysis of gallbladder cancer identifies distinct tumor microenvironments associated with disease progression

PRL3-zumab as an anti-angiogenic therapy in neovascular eye diseases

Phospholipid biosynthesis modulates nucleotide metabolism and reductive capacity

Macrophage lineage cells-derived migrasomes activate complement-dependent blood-brain barrier damage in cerebral amyloid angiopathy mouse model

Structural snapshots of human pre-60S ribosomal particles before and after nuclear export

Prompt-to-afterglow transition of optical emission in a long gamma-ray burst consistent with a fireball

An atlas of gene regulatory elements in adult mouse cerebrum

Electrochemically induced nickel catalysis for oxygenation reactions with water

A rare deep intronic mutation of PKHD1 gene, c.8798-459 C > A, causes autosomal recessive polycystic kidney disease by pseudoexon activation

Evolution of coastal forests based on a full set of mangrove genomes

An improved Gaussian process for filling the missing data in GNSS position time series considering the influence of adjacent stations

Towards precision medicine based on a continuous deep learning optimization and ensemble approach

The neglected role of micronutrients in predicting soil microbial structure

The Asian arowana (Scleropages formosus) genome provides new insights into the evolution of an early lineage of teleosts

A longitudinal resource for population neuroscience of school-age children and adolescents in China

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