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Here, the authors identify a copy number variation containing three enhancers (PIHEC) that drives bilateral constricted ear by co-ordinately regulating HMX1 expression, revealing how aberrant Hmx1 expression in neural crest-derived fibroblasts disrupts outer ear development.

An electron transfer mechanism that involves a light-triggered geometric conversion between metal and oxygen redox chemistry shows superior performance compared with approaches that use either metal or oxygen redox chemistry.

Scaling up perovskite film deposition necessitates controlling the film formation dynamics. Here, Deng et al. use amphoteric choline surfactants to blade-coat well-passivated films, reaching module efficiencies of ~15% for aperture areas up to 57 cm².

Digital polymers with precisely ordered units for next-generation data storage media are continually investigated for higher storage capacity. Here the authors show the synthesis of information-coded 2D digital dendrimers and the generated data matrix barcode can be read by a common hand-held device.

The development of future computation devices will be aided by a better understanding of the physics underlying material behaviors. Using thermoreflectance and spatially resolved X-ray microscopy, Kumar et al. elucidate the origin of two types of negative differential resistance in NbO₂ memristors.

Photothermal superhydrophobic coatings show poor anti-icing performance and mechanical stability in real conditions. Here, authors report on robust photothermal superhydrophobic coatings with self-similar low-surface-energy three-tier micro-/nano- /nanostructures.

The fabrication of perovskite solar cells in ambient air is of interest, but the materials are unstable in the presence of moisture. Yan et al. show that guanabenz acetate salt eliminates vacancy defects that trigger perovskite degradation, enabling 25% efficiency devices to be fabricated in air.

Thermally conductive polymers can be used for advanced thermal management applications but the transport mechanisms have yet to be elucidated. Here the authors report the synthesis of polyethylene films with high thermal conductivity, which is attributed to the amorphous regions of the nanofibers.

Here, the authors experimentally demonstrate abilities of a mechanical Willis meta-layer, in beams and plates, for independently engineering transmission and reflection coefficients of flexural waves in both amplitude and phase and nonreciprocal wave propagation.

Patients treated for multiple myeloma often experience relapse due to antigen loss, thus necessitating the identification of additional therapeutic targets. In this study, the authors demonstrate that FcRH5 is expressed on MM cells and can be targeted using chimaeric antigen receptor T cells in mice.

Initial reports suggest unique radiation tolerance of perovskite solar cells. Here, the authors expose both n-i-p and p-i-n devices to low- and high-energy protons, providing a direct proof of radiation-induced efficiency recovery via tuning radiation-matter interactions in the devices.

Cross-hatch impressions from Ediacaran rocks in China are interpreted as having been left by a crown-group sponge fossil, Helicolocellus cantori gen. et sp. nov., characterized by an organic latticework skeleton.

Mechanical metamaterials can be engineered with properties not possible in ordinary materials. Here the authors demonstrate and study an active metamaterial with self-sensing characteristics that enables odd elastic properties not observed in passive media.

While perovskite solar cells with an inverted architecture hold great promise for operation stability, their power conversion efficiency lags behind that of conventional cells. Here, Zheng et al. achieve a certified 22.34% efficiency, exploiting alkylamine ligands as grain and interface modifiers.

The authors report a controllable third-order cusp singularity in the phase-tracked closed-loop oscillation of two coupled mechanical modes. This finding addresses the challenge of constructing and controlling higher-order singularities.

The authors investigate junctions made of two flakes of the cuprate superconductor Bi₂Sr_2-xLa_xCuO_6+y (Bi2201) twisted by 45 degrees. They find evidence for an isotropic pairing component, and call into question theoretical predictions of d+id superconductivity in this system.

Development of suitable methanol oxidation reaction catalysts for direct methanol fuel cells is challenging due to sluggish kinetics. Herein, authors show that four-coordinate nickel atoms form charge-transfer orbitals near the Fermi energy level, leading to remarkable methanol oxidation activity.

The NLRP3 inflammasome plays a pivotal role in clearing viral respiratory infection, but the molecular mechanism is not fully known. Here authors show that acetate, produced by gut bacteria, may enhance NLRP3-mediated type I interferon production following influenza infection in mice.

Good impalement resistance, mechanical robustness and weather resistance are essential for applications of superhydrophobic coatings. Here, the authors achieve scalable preparation and practical application of robust superhydrophobic coatings for preventing rain attenuation of 5G/weather radomes.

Losses in solar cells can be caused by material defects in the bulk or at interfaces. Here, Zheng et al. use quaternary ammonium halides to passivate various perovskite absorbers and prepare solar cells with certified efficiency above 20%, suggesting that both anionic and cation defects are affected.

A direct search for effective electromagnetic interactions between dark matter and xenon nuclei that produce a recoil of the latter is carried out and the first constraint on charge radius of dark matter is derived.

The performance of a metal halide perovskite single crystal is governed by the defect density. Here, the authors report a high quality single crystal perovskite grown by a ligand-assisted solution process with DPSI achieving 23-fold smaller trap density than that without DPSI.

Mechanically interlocked molecules are extensively applied as artificial molecular machines but rotaxane-branched dendrimers are rarely explored because of synthetic challenges. Here the authors present the construction of dual stimuli-responsive rotaxane-branched dendrimer which can be stimulated by DMSO or acetate ions.

Encoded Library Technology (ELT) has streamlined the identification of chemical ligands for protein targets in drug discovery. Here, the authors optimize the ELT approach to screen multiple proteins in parallel and identify promising targets and antibacterial compounds forS. aureus, A. baumannii and M. tuberculosis.

Mesocrystal formation is investigated for haematite in the presence of oxalate, showing that chemical gradients at interfaces cause nucleation near surfaces rather than in the bulk, followed by particle attachment.

In glioma STAT3 signaling contributes to gliomagenesis. Here, the authors show that Smad6 expression correlates with poor survival and is overexpressed in glioma cells, and regulates STAT3 activity via negatively regulating PIAS3.

In this study, the authors propose a generic machine-learning-assisted framework to improve the overall performance of quantum sensing application. In the context of an atomic force sensor, this entirely data-driven approach, which involves generating the digital twinning of experimental data, demonstrates an order of magnitude improvement in sensitivity compared to conventional protocols.