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A wax-aided immersion methodology is developed to yield graphene rolls with tunable chiral angles; these graphene rolls exhibit promising chiral electronic properties beyond those of other carbon allotropes.

Duchenne muscular dystrophy (DMD) is a fatal genetic disorder caused by mutations in the DMD gene. Here, the authors develop MyoAAV-UA, a compact utrophin activator, as a promising universal treatment for DMD through a homologous protein activation approach.

A telomere-to-telomere genome assembly of allohexaploid bread wheat cv. Chinese Spring (CS-IAAS), along with transcriptomic and proteomic data, highlights wheat genome complexity and its structural and functional features.

Catenated cages are challenging synthetic targets in chemistry. Here, the authors employ a multi-component coordination strategy using a Pt(II) heteroligation to construct a cyclic bis[2]catenane metallacage, which could be reversibly transformed between the catenated structure and the bis-metallacage.

Coordination-driven supramolecular assembly provides the ability to build molecular architectures of impressive complexity. Here, the authors use a series of linear metal-organic ligands with specific sequences to construct multiple generations of precisely-controlled, 2D fractal polycyclic supramolecules.

The innate immune response to many RNA viruses depends on recognition of viral RNA by RIG-I. Here the authors show that, upon virus infection, FBXW7 interacts with RIG-I and inhibits ubiquitin-mediated degradation of RIG-I, resulting in increased interferon signallingin vitro and in vivo.

Deforestation is often driven by land conversion for growing commodity crops. This study finds that, between 2000 and 2019, most soybean expansion in South America was on pastures converted originally for cattle production, especially in the Brazilian Amazon. More soy-driven deforestation occurred in the Brazilian Cerrado.

Transposable elements (TEs) pose challenges for quantification due to multi-mapping reads. Here, authors present MATES, a deep learning method that accurately assigns reads to specific TE loci, enhancing TE quantification in single-cell omics datasets and identifying marker TEs in cell populations.

Atomically dispersed metallic materials attract tremendous attention. Here the authors explore a general method based on the discrepancy in cohesive energy of the metals to synthesize a large library of bi-/multi-metallic single atom/atomic cluster materials for electrocatalytic hydrogen evolution.

A direct lead-halide perovskite CT imager has been demonstrated. The detector arrays have 980 μm absorber thickness and exhibit detection quantum efficiency of 80% and noise-equivalent dose of 153 pGy_air.

Ruiheng Sima and colleagues report a space temperature traceability technology, achieving continuous self-calibration through near-site transfer of miniature fixed points. This provides on-orbit traceability for long-term remote sensing precision.

Conflicts are known to disrupt agriculture, food supply chains and the economy at large. Mapping and quantifying such disruptions, although key for aid planning, remains a challenge in war zones. This study uses daytime and night-time satellite data from Syria over 1998–2019 to assess the link between war-induced impacts on infrastructure and urban areas with cropland dynamics.

While perovskite solar cells with an inverted architecture hold great promise for operation stability, their power conversion efficiency lags behind that of conventional cells. Here, Zheng et al. achieve a certified 22.34% efficiency, exploiting alkylamine ligands as grain and interface modifiers.

Many genome-wide datasets from various sources are combined to generate an integrative gene regulatory network in Arabidopsis. This network is used to predict and validate new transcriptional regulators of ROS signalling.

This study uses 30-m cropland maps to show that cropland expansion in protected areas accelerated dramatically from 2000 to 2019, compared with the expansion of global croplands, threatening the aspirations of the post-2020 global biodiversity framework.

Differential spectrometers recognise different wavelength via their differential photodetector responsivity. The authors combine an 8-pixel hemispherical perovskite photodetector with neural network algorithms to realise 3D trajectory tracking and 2D ___location tacking with colour classification.

Identifying and quantifying the biodistribution of synthetic polymeric nanoparticles in biological milieu is crucial for biomedical applications. Now, it has been shown that encoded polymeric amphiphiles with discrete molar masses undergo sequence- and length-dependent self-assembly into precise digital micelles that can be used in direct sequence reading and ex vivo label-free quantification assays.

In this study, Qin et al. present a murine-adapted SARS-CoV-2 strain, MASCp36, as a model for studying the pathogenicity, evolution and adaptation of the virus to human and animal hosts.

The NLRP3 inflammasome plays a pivotal role in clearing viral respiratory infection, but the molecular mechanism is not fully known. Here authors show that acetate, produced by gut bacteria, may enhance NLRP3-mediated type I interferon production following influenza infection in mice.

Thermally conductive polymers can be used for advanced thermal management applications but the transport mechanisms have yet to be elucidated. Here the authors report the synthesis of polyethylene films with high thermal conductivity, which is attributed to the amorphous regions of the nanofibers.

Because open-circuit voltage deficit is greater in wide-bandgap perovskite solar cells, the authors introduce diammonium molecules to modify perovskite surface states and achieve a more uniform spatial distribution of surface potential, enabling record voltage all-perovskite tandem solar cells.

Hemispherical photodetectors allow wide sight angle without the complex optical paths of fisheye lenses. Here, Wei et al, report a spray-coated quasi-two-dimensional perovskite hemispherical photodetector with wavelength selective response from the visible to the near-infrared.

Star motifs are ubiquitous throughout nature and in man-made architectures, but their molecular level design remains challenging. Here the authors present a stepwise approach to self-assemble pentagonal and hexagonal star-shaped metallo-architectures through the careful design of metallo-organic ligands.

Metal coordination of multitopic ligands is a powerful approach to building complex, functional architectures. Here, the authors construct three generations of fluorescent supramolecular rosettes by coordination of aggregation-induced emissive ligands, including a 2nd-generation macrocycle that emits pure white light.

Intermetallic nanoparticles comprised of early transition metals are attractive for fuel cell applications, but are generally limited to noble metal-based systems. Here, authors report non-precious early transition metal intermetallic nanoparticles with promising electrocatalytic performance for the hydrazine oxidation reaction.

Sun et al. uncover a conserved mechanism by which ribosomes function in defining the position of pachytene piRNA formation on long single-stranded RNAs during spermatogenesis.

Metal-mediated self-assembly in solution typically leads to small two- and three-dimensional architectures on scales smaller than 10 nm, but now a series of large, discrete, two-dimensional supramolecular hexagonal grids have been prepared through a combination of intra- and intermolecular coordination interactions. These 20-nm-wide grids have been imaged at submolecular resolution using scanning tunnelling microscopy.

Mesocrystal formation is investigated for haematite in the presence of oxalate, showing that chemical gradients at interfaces cause nucleation near surfaces rather than in the bulk, followed by particle attachment.

The authors present an experimental framework for achieving photonic Landau quantization, and present the quantized distribution of photonic states across different Landau levels in a two-dimensional Kagome metal lattice. They experimentally observe that the electric field distribution is localized according to the positional attributes of different Landau levels.

Tumor–normal paired DNA samples from a breast cancer cell line and a matched lymphoblastoid cell line enable calibration of clinical sequencing pipelines and benchmarking ‘tumor-only’ or ‘matched tumor–normal’ analyses.

In photonic crystal systems, topologically protected edge states and corner states can be achieved by breaking spatial inversion symmetry. The authors propose a broadband valley photonic crystal with a relative bandwidth up to 59.65%, demonstrating ultrabroadband topological transmission and two types of corner states with valley switch ability and selectivity.