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This study shows how auditory cortex activation and cognitive function develop during a six-month follow-up after gene therapy in children with congenital deafness.

Medical devices face stability challenges in extreme pH conditions. Here, the authors report a liquid-based encapsulation approach that achieves year-long encapsulation in acidic conditions

The genomic and immune landscape of pre-invasive lung adenocarcinoma is poorly understood. Here, the authors perform exome and transcriptome sequencing on precursor legions and invasive lung adenocarcinomas, identifying recurrently mutated genes in pre/minimally invasive cases, and arm level alteration events linked to immune infiltration.

An interim analysis of a single-arm trial in 5 children with hereditary deafness shows that binaural AAV gene therapy is safe and leads to hearing improvement up to 13–26 weeks of follow-up.

Chromatin-associated RNAs play various roles in gene regulation and genome organization, yet they remain challenging to interrogate. Here the authors report a targeted DNA-associated RNA and RNA-RNA interaction mapping method and use it to identify caRNAs at DNA anchor regions associated with chromatin loops.

Unfairness in AI healthcare models arise from biased correlations between sensitive attributes and disease data. Here, the authors show that the Attribute Neutral Framework reduces these biases and enhances fairness without compromising diagnostic accuracy.

Carbapenem-resistant Acinetobacter baumannii is an important nosocomial pathogen that can cause outbreaks. In 2019, these authors conducted a genomic surveillance study of A baumannii in an intensive care unit in China, and here they report findings from a follow up study in 2021.

The efficacy of cancer immunotherapy relies on the sufficient functional immune cells recruited. Here this group designs an abemaciclib-loaded supramolecular peptide hydrogel achieving sustained release after intratumoral injection to effectively induce cancer cell death and increase IL-2 secretion, thereby exerting immunotherapy for triple-negative breast cancer.

Indicine cattle make up half of all cattle populations worldwide. Using a large genomic dataset, this study finds historic migrations and extensive introgression with domestic and wild bovine species has facilitated this species physiological adaptation to extreme environments.

All-solid-state sodium-ion batteries are promising candidates for grid-scale energy storage, but they require superior solid-state electrolytes (SSEs). Here sodium-ion SSEs based on dual-anion frameworks of oxychloride are studied and found to show high ionic conductivity and electrochemical oxidative stability with mechanical softness.

This new β-Li₃N solid-state electrolyte demonstrates a vacancy-mediated superionic diffusion mechanism, achieving high ionic conductivity (2.14 × 10⁻³ S cm⁻¹) and effectively suppressing lithium dendrite growth. Its high compatibility with lithium and air stability promises improved safety and performance in all-solid-state lithium metal batteries, making it ideal for advanced energy storage applications.

A benchmarking competition improves tools that predict how regulatory regions control gene expression.

Congenital heart disease is life threatening, and its screening is complex and costly. Here, authors use AI to detect the disease based on pediatric electrocardiogram, suggesting superior performance over cardiologists.

A high-density genomic variation map from 744 genomes encompassing maize and all wild taxa of the genus Zea reveals evidence of adaptive variation and provides a genus-wide resource of genetic diversity in Zea.

Here, the authors use SNP-seq to screen 87 lupus risk loci for functional non-coding variants. Validation at one locus identified a risk variant through which enhanced Ikaros binding amplifies expression of the interferon / NFκB regulator IKKε.

Enzalutamide, an approved drug for prostate cancer, acts on TMPRSS2 expression, a key mediator for SARS-CoV-2 infection. Here, the authors characterize the anti-SARS-CoV-2 effects of Enzalutamide in prostate cancer cells, lung cancer cells, human lung organoids and in hACE2-transduced Tmprss2 knockout mice and show lack antiviral action in human lung cells and human lung organoids, likely due to the AR-independent TMPRSS2 expression in mouse and human lung epithelial cells.

Naive T cells are quiescent but undergo dynamic changes upon antigenic activation. Li and colleagues show that upregulation of tRNA methyltransferase complex TRMT61A–TRMT6 and N¹-methyladenosine modification of tRNAs contribute to accelerated mRNA translation efficiency, in particular that of MYC protein, and are required for rapid T cell proliferation.

This Review discusses the role of phosphatidylinositol phosphates and their modifying enzymes in modulating cell motility and adhesion and emphasizes the potential of targeting the associated pathways for therapeutic benefit.

Click-ExM uses click-chemistry-based labeling to increase the versatility of expansion microscopy. Click-ExM enables imaging of numerous classes of biomolecules including lipids, glycans, proteins, DNA, RNA and small molecules.

Population level transcriptomics measurements miss bacterial heterogeneity. Here the authors report smRandom-seq, a droplet-based high-throughput single-microbe RNA-seq assay, using random primers for in situ cDNA generation, droplets for single-microbe barcoding, and CRISPR-based rRNA depletion.

Understanding how palladium inhibits CO poisoning is important for rational design of enhanced catalysts. Here the authors show high formate coverage on the palladium-modified electrode inhibits poisoning during formic acid oxidation and the adsorption of CO precursor dictates the delayed poisoning during CO2 reduction.

Bilayer graphene (BLG) is promising for optoelectronic applications due to its tunable bandgap, but its large-area growth on Cu substrates is still challenging. Here, the authors demonstrate the fast synthesis of high-coverage meter-scale BLG on commercial Cu foils by introducing CO₂ during the growth.

Thousands of genetic variants have been associated with lupus, but causal variants and mechanisms are unknown. Here, the authors combine a massively parallel reporter assay with genome-wide ChIP experiments to identify risk variants with allelic enhancer activity mediated through transcription factor binding.

Fine-mapping has previously implicated the non-coding single nucleotide polymorphism rs117701653 as a risk variant for rheumatoid arthritis and type 1 diabetes, however its function remained unclear. Here the authors show that this variant decreases binding of the inhibitory factor SMCHD1 to enhance expression of ICOS, promoting development of potentially pathogenic T peripheral helper cells.

Linking transcription factors with disease loci implicates EBNA2, encoded by Epstein–Barr virus, in autoimmune diseases. Applying the method more widely identifies associations for hundreds of transcription factors, illuminating disease mechanisms.

Implantation-associated infections often lead to infections. Here, the authors propose a piezo-based nanoreactor to achieve US-excited tandem catalysis, endowing the polyetherketoneketone bone scaffold with on-demand antibacterial and osteogenic capacities.

Shi and colleagues show that PUS7 controls tRNA pseudouridylation and codon-specific translation to fuel glioblastoma tumorigenesis, and discover a PUS7 inhibitor that delays tumor growth in glioblastoma models.

Stress release at stepped platinum surfaces is shown to influence the strain experienced by atoms near the steps, resulting in effects on the catalytic activity of the whole surface.

Compromised function of regulatory T cells can lead to autoimmunity. Here the authors show that miR-125a stabilizes regulatory T-cell function and is downregulated in lupus and Crohn’s disease, as well as autoimmune mouse models, and that a chemical miR-125a analogue reverts established disease in a mouse model of multiple sclerosis.

Spines are an important physical defense for many plant species. Here, the authors describe seven different spine morphologies from the Eocene of central Tibet associated with regional aridification and expansion of herbivorous mammals.

Long non-coding RNAs are important regulators of many diverse biological processes. Here the authors describe Linc-RAM, which regulates myogenesis by binding MyoD and promoting the assembly of the MyoD–Baf60c–Brg1 complex at target genes.

Biodiversity-ecosystem functioning relationships may vary with climate. Here, the authors study relationships of plant and soil microbial diversity with soil nutrient multifunctionality in 130 dryland sites in China, finding a shift towards greater importance of soil microbial diversity in arid conditions.

Mild cold exposure activates a substantial amount of brown adipose tissue (BAT) in a patient with cancer, reducing tumour-associated glucose uptake, and activation of BAT in mice inhibits the growth of tumours by decreasing blood glucose and impeding glycolysis-based metabolism in cancer cells.

Mammalian skeletal muscle is composed of multinucleated myofibers, containing hundreds of nuclei that coordinate cellular function. Here, the authors show that single-nucleus RNA-sequencing reveals rare and emergent myonuclear populations, and uncovers dynamic transcriptional heterogeneity in development and aging.

White adipose inflammation can occur in obesity and is at least in part mediated by inflammatory immune cells. Here the authors show that the Type I Interferon/Interferon alpha-beta receptor axis promotes an inflammatory, glycolysis associated adipocyte phenotype.